YDR240C / SNU56

Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR240C / SNU56

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.10|P-value:1.14E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.64|P-value:5.33E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.59|P-value:1.86E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:4.13|P-value:1.04E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.87|P-value:2.57E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:6.17|P-value:1.45E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:3.70|P-value:4.51E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.71|P-value:4.14E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.75|P-value:3.58E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.57|P-value:6.72E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.77|P-value:3.60E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.62|P-value:1.65E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.21|P-value:7.85E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:6.30|P-value:7.29E-9 ID:SGTC_946|Compound:3434-1334|FD-Score:3.86|P-value:2.64E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.10|P-value:1.16E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.93|P-value:2.00E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.49|P-value:8.52E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.97|P-value:1.72E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.52|P-value:7.39E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.52|P-value:2.49E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.98|P-value:3.58E-8 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.39|P-value:4.06E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.93|P-value:2.00E-4 ID:SGTC_1731|Compound:st035964|FD-Score:6.37|P-value:5.02E-9 ID:SGTC_2004|Compound:4023728|FD-Score:-8.31|P-value:3.53E-14 ID:SGTC_2125|Compound:5246583|FD-Score:-3.96|P-value:1.77E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.05|P-value:1.37E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.79|P-value:3.12E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.89|P-value:2.29E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.01|P-value:1.56E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.96|P-value:3.84E-6 ID:SGTC_2804|Compound:7954240|FD-Score:5.70|P-value:1.49E-7 ID:SGTC_2995|Compound:9067767|FD-Score:-3.90|P-value:2.19E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-4.18|P-value:8.34E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-4.03|P-value:1.39E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.04|P-value:2.59E-8 ID:SGTC_3095|Compound:9117207|FD-Score:-3.82|P-value:2.86E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.78|P-value:3.38E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.10|P-value:1.14E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.64|P-value:5.33E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.59|P-value:1.86E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:4.13|P-value:1.04E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.87|P-value:2.57E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:6.17|P-value:1.45E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:3.70|P-value:4.51E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.71|P-value:4.14E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:-3.75|P-value:3.58E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.57|P-value:6.72E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:3.77|P-value:3.60E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:4.62|P-value:1.65E-5 ID:SGTC_818|Compound:4072-2707|FD-Score:4.21|P-value:7.85E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:6.30|P-value:7.29E-9 ID:SGTC_946|Compound:3434-1334|FD-Score:3.86|P-value:2.64E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.10|P-value:1.16E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.93|P-value:2.00E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.49|P-value:8.52E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-3.97|P-value:1.72E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-3.52|P-value:7.39E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.52|P-value:2.49E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.98|P-value:3.58E-8 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.39|P-value:4.06E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.93|P-value:2.00E-4 ID:SGTC_1731|Compound:st035964|FD-Score:6.37|P-value:5.02E-9 ID:SGTC_2004|Compound:4023728|FD-Score:-8.31|P-value:3.53E-14 ID:SGTC_2125|Compound:5246583|FD-Score:-3.96|P-value:1.77E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.05|P-value:1.37E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.79|P-value:3.12E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.89|P-value:2.29E-4 ID:SGTC_2440|Compound:5628896|FD-Score:4.01|P-value:1.56E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.96|P-value:3.84E-6 ID:SGTC_2804|Compound:7954240|FD-Score:5.70|P-value:1.49E-7 ID:SGTC_2995|Compound:9067767|FD-Score:-3.90|P-value:2.19E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-4.18|P-value:8.34E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-4.03|P-value:1.39E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.04|P-value:2.59E-8 ID:SGTC_3095|Compound:9117207|FD-Score:-3.82|P-value:2.86E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.78|P-value:3.38E-4

Top fitness defect scores for YDR240C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1731 st035964 6.37 63.0 µM 5.02E-9 4 9.17E-11 0.96
2 SGTC_824 1304-0008 6.30 100.0 µM 7.29E-9 DNA damage response 1 1.45E-10 0.81
3 SGTC_366 0181-0206 6.17 4.3 µM 1.45E-8 Golgi 3 3.38E-10 0.46
4 SGTC_2804 7954240 5.70 19.5 µM 1.49E-7 5 5.94E-9 0.90
5 SGTC_816 0325-0417 4.62 81.3 µM 1.65E-5 1 1.92E-6 0.73
6 SGTC_264 promethazine 4.59 12.5 mM 1.86E-5 DNA intercalators 18 2.22E-6 0.25
7 SGTC_1348 1493-0373 4.52 93.8 µM 2.49E-5 3 3.16E-6 0.48
8 SGTC_1389 3405-0187 4.39 19.0 µM 4.06E-5 3 5.76E-6 0.49
9 SGTC_818 4072-2707 4.21 53.5 µM 7.85E-5 7 1.29E-5 0.10
10 SGTC_344 k064-0035 4.13 6.4 µM 1.04E-4 60S ribosome export 5 1.82E-5 0.02
11 SGTC_40 0327-0103 4.10 19.8 µM 1.14E-4 5 2.03E-5 0.38
12 SGTC_1078 idebenone 4.10 36.1 µM 1.16E-4 Golgi 3 2.08E-5 0.07
13 SGTC_2408 sulbentine 4.05 18.4 µM 1.37E-4 32 2.56E-5 0.01
14 SGTC_2440 5628896 4.01 157.8 µM 1.56E-4 6 2.99E-5 0.14
15 SGTC_365 0121-0052 3.87 13.6 µM 2.57E-4 mitochondrial response to ROS 8 5.52E-5 0.06
16 SGTC_946 3434-1334 3.86 87.4 µM 2.64E-4 11 5.69E-5 0.01
17 SGTC_3207 9114163 3.78 49.5 µM 3.38E-4 12 7.70E-5 0.02
18 SGTC_814 3342-0569 3.77 96.0 µM 3.60E-4 2 8.32E-5 0.16
19 SGTC_372 0155-0182 3.70 15.9 µM 4.51E-4 mitochondrial response to ROS 7 1.10E-4 0.05
20 SGTC_97 0535-0701 3.64 19.1 µM 5.33E-4 60S ribosome export 12 1.34E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 8.01E-19 YML109W ZDS2 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication
0.117 9.42E-12 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.117 9.28E-12 YNL151C RPC31 het RNA polymerase III subunit C31
0.116 1.76E-11 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.108 4.39E-10 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.101 4.84E-9 YKL096W-A CWP2 hom Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
0.098 1.41E-8 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.089 2.21E-7 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.089 2.56E-7 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.087 3.88E-7 YOR223W YOR223W hom Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
0.083 1.58E-6 YKR056W TRM2 hom tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
0.083 1.61E-6 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.082 1.77E-6 YDR062W LCB2 het Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.078 6.13E-6 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.077 8.82E-6 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data