YDR241W_d / BUD26

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR241W / BUD26

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.76|P-value:1.88E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.43|P-value:1.35E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:4.07|P-value:5.91E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.68|P-value:4.79E-6 ID:SGTC_276|Compound:colchicine|FD-Score:5.53|P-value:8.52E-8 ID:SGTC_317|Compound:4495-0002|FD-Score:3.45|P-value:5.41E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.44|P-value:5.62E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.97|P-value:8.44E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.73|P-value:3.76E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.61|P-value:3.11E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.80|P-value:1.59E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.58|P-value:7.16E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:3.92|P-value:1.03E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.55|P-value:3.94E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.74|P-value:2.10E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:5.00|P-value:1.10E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.80|P-value:1.06E-20 ID:SGTC_770|Compound:0389-1121|FD-Score:3.42|P-value:6.00E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.01|P-value:7.28E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.79|P-value:1.65E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.65|P-value:2.79E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.32|P-value:8.24E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.32|P-value:8.41E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.18|P-value:3.84E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.47|P-value:5.12E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.46|P-value:5.30E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.68|P-value:2.50E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.86|P-value:1.32E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.08|P-value:5.53E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.54|P-value:4.07E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.48|P-value:5.08E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.31|P-value:8.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.54|P-value:8.83E-6 ID:SGTC_1919|Compound:st067113|FD-Score:5.90|P-value:1.18E-8 ID:SGTC_2044|Compound:5102272|FD-Score:3.82|P-value:1.49E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.26|P-value:9.96E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.88|P-value:1.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.94|P-value:9.63E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.77|P-value:1.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.66|P-value:2.69E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.23|P-value:3.97E-12 ID:SGTC_2710|Compound:st078562|FD-Score:3.83|P-value:1.46E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.53|P-value:4.35E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.60|P-value:3.45E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.51|P-value:4.49E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.79|P-value:1.72E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.48|P-value:4.87E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.57|P-value:3.76E-4 ID:SGTC_2817|Compound:7995342|FD-Score:4.63|P-value:5.76E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.67|P-value:2.54E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.37|P-value:7.38E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-4.13|P-value:4.83E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.29|P-value:9.21E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.58|P-value:6.37E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-3.62|P-value:3.20E-4 ID:SGTC_3270|Compound:9137563|FD-Score:4.09|P-value:5.44E-5 ID:SGTC_3272|Compound:9137413|FD-Score:5.88|P-value:1.29E-8 ID:SGTC_3345|Compound:9148410|FD-Score:-3.57|P-value:3.79E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.76|P-value:1.88E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.43|P-value:1.35E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:4.07|P-value:5.91E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.68|P-value:4.79E-6 ID:SGTC_276|Compound:colchicine|FD-Score:5.53|P-value:8.52E-8 ID:SGTC_317|Compound:4495-0002|FD-Score:3.45|P-value:5.41E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.44|P-value:5.62E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.97|P-value:8.44E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:4.73|P-value:3.76E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:3.61|P-value:3.11E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.80|P-value:1.59E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.58|P-value:7.16E-6 ID:SGTC_642|Compound:0335-0876|FD-Score:3.92|P-value:1.03E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.55|P-value:3.94E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:-3.74|P-value:2.10E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:5.00|P-value:1.10E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-9.80|P-value:1.06E-20 ID:SGTC_770|Compound:0389-1121|FD-Score:3.42|P-value:6.00E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.01|P-value:7.28E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.79|P-value:1.65E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:3.65|P-value:2.79E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.32|P-value:8.24E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.32|P-value:8.41E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.18|P-value:3.84E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.47|P-value:5.12E-4 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.46|P-value:5.30E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.68|P-value:2.50E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.86|P-value:1.32E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.08|P-value:5.53E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.54|P-value:4.07E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.48|P-value:5.08E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.31|P-value:8.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.54|P-value:8.83E-6 ID:SGTC_1919|Compound:st067113|FD-Score:5.90|P-value:1.18E-8 ID:SGTC_2044|Compound:5102272|FD-Score:3.82|P-value:1.49E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.26|P-value:9.96E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.88|P-value:1.20E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.94|P-value:9.63E-5 ID:SGTC_2423|Compound:st077119|FD-Score:3.77|P-value:1.79E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.66|P-value:2.69E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.23|P-value:3.97E-12 ID:SGTC_2710|Compound:st078562|FD-Score:3.83|P-value:1.46E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:-3.53|P-value:4.35E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:-3.60|P-value:3.45E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:3.51|P-value:4.49E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.79|P-value:1.72E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.48|P-value:4.87E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.57|P-value:3.76E-4 ID:SGTC_2817|Compound:7995342|FD-Score:4.63|P-value:5.76E-6 ID:SGTC_2890|Compound:9046729|FD-Score:3.67|P-value:2.54E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.37|P-value:7.38E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-4.13|P-value:4.83E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.29|P-value:9.21E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.58|P-value:6.37E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-3.62|P-value:3.20E-4 ID:SGTC_3270|Compound:9137563|FD-Score:4.09|P-value:5.44E-5 ID:SGTC_3272|Compound:9137413|FD-Score:5.88|P-value:1.29E-8 ID:SGTC_3345|Compound:9148410|FD-Score:-3.57|P-value:3.79E-4

Top fitness defect scores for YDR241W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.23 96.7 µM 3.97E-12 calcium & mitochondrial duress 97 2.42E-13
2 SGTC_1919 st067113 5.90 52.3 µM 1.18E-8 TSC3-RPN4 10 1.81E-9
3 SGTC_3272 9137413 5.88 49.5 µM 1.29E-8 2 2.00E-9
4 SGTC_3212 9128307 5.58 49.5 µM 6.37E-8 18 1.18E-8
5 SGTC_276 colchicine 5.53 750.0 µM 8.52E-8 5 1.64E-8
6 SGTC_756 0508-1999 5.00 28.3 µM 1.10E-6 RPP1 & pyrimidine depletion 8 2.84E-7
7 SGTC_422 cantharidin 4.73 155.0 µM 3.76E-6 cell wall signaling 37 1.11E-6
8 SGTC_212 3807-4682 4.68 38.8 µM 4.79E-6 tubulin folding & SWR complex 43 1.46E-6
9 SGTC_2817 7995342 4.63 71.4 µM 5.76E-6 14 1.79E-6
10 SGTC_608 k048-0125 4.58 159.0 µM 7.16E-6 17 2.27E-6
11 SGTC_1844 rapamycin 4.54 4.0 nM 8.83E-6 126 2.87E-6
12 SGTC_118 0083-0097 4.43 135.3 µM 1.35E-5 translation 89 4.61E-6
13 SGTC_1394 3474-0001 4.18 65.7 µM 3.84E-5 endomembrane recycling 34 1.47E-5
14 SGTC_3270 9137563 4.09 49.5 µM 5.44E-5 RPP1 & pyrimidine depletion 6 2.17E-5
15 SGTC_1728 st035614 4.08 33.8 µM 5.53E-5 40 2.21E-5
16 SGTC_176 1486-1328 4.07 72.8 µM 5.91E-5 49 2.38E-5
17 SGTC_824 1304-0008 4.01 100.0 µM 7.28E-5 DNA damage response 39 3.00E-5
18 SGTC_367 0335-0881 3.97 7.1 µM 8.44E-5 ubiquinone biosynthesis & proteasome 80 3.54E-5
19 SGTC_2238 6671620 3.94 73.2 µM 9.63E-5 32 4.09E-5
20 SGTC_642 0335-0876 3.92 158.0 µM 1.03E-4 ubiquinone biosynthesis & proteasome 42 4.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.04E-22 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.156 9.96E-20 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.155 1.95E-19 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.152 9.62E-19 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.148 6.44E-18 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.148 8.04E-18 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.147 1.18E-17 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.146 1.99E-17 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.143 7.84E-17 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.139 5.40E-16 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.139 5.68E-16 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.137 1.29E-15 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.133 1.04E-14 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.133 9.91E-15 YNL288W CAF40 hom Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
0.130 4.56E-14 YGR078C PAC10 hom Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding