YDR246W / TRS23

One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR246W / TRS23

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:2.70|P-value:5.00E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-2.57|P-value:7.99E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:2.66|P-value:6.17E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-2.82|P-value:2.75E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.75|P-value:4.07E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-2.60|P-value:6.96E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.85|P-value:2.67E-4 ID:SGTC_470|Compound:aa-861|FD-Score:2.77|P-value:3.83E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.67|P-value:5.84E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.74|P-value:3.84E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-2.61|P-value:6.72E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-2.81|P-value:2.83E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.91|P-value:1.77E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.14|P-value:6.73E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.21|P-value:4.61E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-2.67|P-value:5.32E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.20|P-value:4.96E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.24|P-value:3.52E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-2.58|P-value:7.70E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.15|P-value:6.42E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.31|P-value:2.81E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.63|P-value:4.20E-6 ID:SGTC_1893|Compound:st059353|FD-Score:4.00|P-value:5.39E-7 ID:SGTC_1903|Compound:st060211|FD-Score:2.59|P-value:8.27E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-2.59|P-value:7.52E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.84|P-value:2.77E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-4.02|P-value:4.12E-7 ID:SGTC_2016|Compound:5121758|FD-Score:-2.65|P-value:5.67E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.67|P-value:3.36E-6 ID:SGTC_2052|Compound:5265182|FD-Score:2.86|P-value:2.52E-4 ID:SGTC_2174|Compound:5790901|FD-Score:2.59|P-value:8.30E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.42|P-value:1.52E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.72|P-value:3.00E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-2.59|P-value:7.40E-4 ID:SGTC_2285|Compound:7945142|FD-Score:2.70|P-value:5.07E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.00|P-value:1.29E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.81|P-value:3.09E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.61|P-value:4.83E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.86|P-value:1.30E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.25|P-value:3.85E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.76|P-value:2.03E-6 ID:SGTC_2803|Compound:7707263|FD-Score:4.25|P-value:1.11E-7 ID:SGTC_3343|Compound:9148379|FD-Score:2.62|P-value:7.31E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.70|P-value:5.00E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-2.57|P-value:7.99E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:2.66|P-value:6.17E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-2.82|P-value:2.75E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.75|P-value:4.07E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-2.60|P-value:6.96E-4 ID:SGTC_433|Compound:pimozide|FD-Score:2.85|P-value:2.67E-4 ID:SGTC_470|Compound:aa-861|FD-Score:2.77|P-value:3.83E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:2.67|P-value:5.84E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.74|P-value:3.84E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:-2.61|P-value:6.72E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:-2.81|P-value:2.83E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.91|P-value:1.77E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.14|P-value:6.73E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.21|P-value:4.61E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:-2.67|P-value:5.32E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.20|P-value:4.96E-5 ID:SGTC_1674|Compound:st016616|FD-Score:-3.24|P-value:3.52E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-2.58|P-value:7.70E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.15|P-value:6.42E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.31|P-value:2.81E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.63|P-value:4.20E-6 ID:SGTC_1893|Compound:st059353|FD-Score:4.00|P-value:5.39E-7 ID:SGTC_1903|Compound:st060211|FD-Score:2.59|P-value:8.27E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-2.59|P-value:7.52E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.84|P-value:2.77E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-4.02|P-value:4.12E-7 ID:SGTC_2016|Compound:5121758|FD-Score:-2.65|P-value:5.67E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.67|P-value:3.36E-6 ID:SGTC_2052|Compound:5265182|FD-Score:2.86|P-value:2.52E-4 ID:SGTC_2174|Compound:5790901|FD-Score:2.59|P-value:8.30E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.42|P-value:1.52E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.72|P-value:3.00E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-2.59|P-value:7.40E-4 ID:SGTC_2285|Compound:7945142|FD-Score:2.70|P-value:5.07E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.00|P-value:1.29E-4 ID:SGTC_2393|Compound:9031399|FD-Score:2.81|P-value:3.09E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.61|P-value:4.83E-6 ID:SGTC_2692|Compound:st077426|FD-Score:3.86|P-value:1.30E-6 ID:SGTC_2693|Compound:st077581|FD-Score:3.25|P-value:3.85E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-3.76|P-value:2.03E-6 ID:SGTC_2803|Compound:7707263|FD-Score:4.25|P-value:1.11E-7 ID:SGTC_3343|Compound:9148379|FD-Score:2.62|P-value:7.31E-4

Top fitness defect scores for YDR246W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2803 7707263 4.25 71.4 µM 1.11E-7 3 1.07E-5 0.50
2 SGTC_1893 st059353 4.00 36.1 µM 5.39E-7 2 3.13E-5 0.20
3 SGTC_2692 st077426 3.86 47.7 µM 1.30E-6 6 5.71E-5 0.03
4 SGTC_2261 9010538 3.72 184.7 µM 3.00E-6 6 1.01E-4 0.01
5 SGTC_2246 7293507 3.42 91.6 µM 1.52E-5 16 3.08E-4 0.02
6 SGTC_1745 st081495 3.31 74.0 µM 2.81E-5 RNA processing & uracil transport 39 4.69E-4 0.01
7 SGTC_2693 st077581 3.25 40.7 µM 3.85E-5 10 5.83E-4 0.06
8 SGTC_798 1287-0182 3.21 476.0 µM 4.61E-5 6 6.60E-4 0.05
9 SGTC_1620 st003704 3.20 16.5 µM 4.96E-5 11 6.94E-4 0.00
10 SGTC_1718 roemerine 3.15 11.9 µM 6.42E-5 redox potentiating 28 8.29E-4 0.07
11 SGTC_756 0508-1999 3.14 28.3 µM 6.73E-5 RPP1 & pyrimidine depletion 19 8.57E-4 0.01
12 SGTC_2288 7946289 3.00 167.3 µM 1.29E-4 15 0.00134 0.04
13 SGTC_2052 5265182 2.86 7.1 µM 2.52E-4 23 0.00213 0.02
14 SGTC_433 pimozide 2.85 108.0 µM 2.67E-4 5 0.00221 0.07
15 SGTC_1924 st058459 2.84 75.1 µM 2.77E-4 12 0.00227 0.13
16 SGTC_2393 9031399 2.81 185.9 µM 3.09E-4 RNA processing & uracil transport 27 0.00245 0.02
17 SGTC_470 aa-861 2.77 153.0 µM 3.83E-4 sphingolipid biosynthesis & PDR1 34 0.00284 0.01
18 SGTC_367 0335-0881 2.75 7.1 µM 4.07E-4 ubiquinone biosynthesis & proteasome 48 0.00297 0.03
19 SGTC_69 0096-0274 2.70 206.7 µM 5.00E-4 mitochondrial processes 66 0.00342 0.04
20 SGTC_2285 7945142 2.70 200.0 µM 5.07E-4 30 0.00346 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 7.90E-25 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.173 5.63E-24 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.149 4.38E-18 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.125 3.62E-13 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.120 2.75E-12 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.114 4.07E-11 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.106 7.61E-10 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.104 1.35E-9 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.100 5.64E-9 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.097 1.95E-8 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.095 3.11E-8 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.093 7.65E-8 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.092 1.00E-7 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.092 1.06E-7 YGR052W_p FMP48_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.090 1.56E-7 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme