YDR247W / VHS1

Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR247W / VHS1

Click on Significant Values for Screen Details ID:SGTC_188|Compound:3229-0966|FD-Score:2.81|P-value:6.15E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-2.85|P-value:3.78E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:2.93|P-value:3.69E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.33|P-value:6.16E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:2.71|P-value:9.14E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.87|P-value:4.82E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.87|P-value:4.74E-4 ID:SGTC_397|Compound:arbidol|FD-Score:2.75|P-value:7.66E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:2.69|P-value:0.00100 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:1.22E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.50|P-value:9.12E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.37|P-value:4.96E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.80|P-value:5.75E-6 ID:SGTC_476|Compound:mead acid|FD-Score:3.74|P-value:7.66E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:-3.76|P-value:4.56E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.64|P-value:9.03E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.24|P-value:4.82E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.73|P-value:5.37E-6 ID:SGTC_978|Compound:1416-0512|FD-Score:2.73|P-value:8.56E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:2.73|P-value:8.38E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.90|P-value:3.28E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.79|P-value:6.01E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.69|P-value:9.93E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.49|P-value:1.90E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.21|P-value:7.64E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.34|P-value:5.72E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.17|P-value:1.27E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.32|P-value:6.46E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.22|P-value:1.02E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.54|P-value:1.51E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.74|P-value:8.15E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.16|P-value:1.32E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.72|P-value:6.46E-4 ID:SGTC_1940|Compound:st075990|FD-Score:2.72|P-value:8.72E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.03|P-value:2.44E-4 ID:SGTC_2036|Compound:5160441|FD-Score:2.85|P-value:5.15E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.77|P-value:7.06E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.36|P-value:2.29E-7 ID:SGTC_2301|Compound:7769476|FD-Score:-3.68|P-value:7.17E-6 ID:SGTC_2303|Compound:7774051|FD-Score:3.64|P-value:1.32E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-2.61|P-value:9.94E-4 ID:SGTC_2342|Compound:7990637|FD-Score:2.76|P-value:7.59E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.08|P-value:1.95E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.78|P-value:4.97E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.71|P-value:6.76E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-2.85|P-value:3.82E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-2.79|P-value:4.80E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.16|P-value:9.42E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.29|P-value:7.42E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.59|P-value:1.67E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-2.90|P-value:3.02E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.98|P-value:3.91E-9 ID:SGTC_2931|Compound:9014674|FD-Score:2.73|P-value:8.42E-4 ID:SGTC_3033|Compound:9090887|FD-Score:2.93|P-value:3.76E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.23|P-value:9.83E-5 ID:SGTC_3068|Compound:9116768|FD-Score:2.81|P-value:6.16E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.31|P-value:3.08E-7 ID:SGTC_3346|Compound:9158254|FD-Score:2.98|P-value:3.01E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:2.81|P-value:6.15E-4 ID:SGTC_200|Compound:k038-0079|FD-Score:-2.85|P-value:3.78E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:2.93|P-value:3.69E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.33|P-value:6.16E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:2.71|P-value:9.14E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:2.87|P-value:4.82E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.87|P-value:4.74E-4 ID:SGTC_397|Compound:arbidol|FD-Score:2.75|P-value:7.66E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:2.69|P-value:0.00100 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:1.22E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.50|P-value:9.12E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.37|P-value:4.96E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.80|P-value:5.75E-6 ID:SGTC_476|Compound:mead acid|FD-Score:3.74|P-value:7.66E-6 ID:SGTC_597|Compound:k018-0003|FD-Score:-3.76|P-value:4.56E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.64|P-value:9.03E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.24|P-value:4.82E-7 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.73|P-value:5.37E-6 ID:SGTC_978|Compound:1416-0512|FD-Score:2.73|P-value:8.56E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:2.73|P-value:8.38E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.90|P-value:3.28E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.79|P-value:6.01E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.69|P-value:9.93E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.49|P-value:1.90E-5 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.21|P-value:7.64E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.34|P-value:5.72E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.17|P-value:1.27E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.32|P-value:6.46E-5 ID:SGTC_1501|Compound:4491-0275|FD-Score:3.22|P-value:1.02E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.54|P-value:1.51E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.74|P-value:8.15E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.16|P-value:1.32E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.72|P-value:6.46E-4 ID:SGTC_1940|Compound:st075990|FD-Score:2.72|P-value:8.72E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.03|P-value:2.44E-4 ID:SGTC_2036|Compound:5160441|FD-Score:2.85|P-value:5.15E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.77|P-value:7.06E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.36|P-value:2.29E-7 ID:SGTC_2301|Compound:7769476|FD-Score:-3.68|P-value:7.17E-6 ID:SGTC_2303|Compound:7774051|FD-Score:3.64|P-value:1.32E-5 ID:SGTC_2323|Compound:6148992|FD-Score:-2.61|P-value:9.94E-4 ID:SGTC_2342|Compound:7990637|FD-Score:2.76|P-value:7.59E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.08|P-value:1.95E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-2.78|P-value:4.97E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.71|P-value:6.76E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-2.85|P-value:3.82E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-2.79|P-value:4.80E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.16|P-value:9.42E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.29|P-value:7.42E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.59|P-value:1.67E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-2.90|P-value:3.02E-4 ID:SGTC_2930|Compound:9013230|FD-Score:4.98|P-value:3.91E-9 ID:SGTC_2931|Compound:9014674|FD-Score:2.73|P-value:8.42E-4 ID:SGTC_3033|Compound:9090887|FD-Score:2.93|P-value:3.76E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.23|P-value:9.83E-5 ID:SGTC_3068|Compound:9116768|FD-Score:2.81|P-value:6.16E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.31|P-value:3.08E-7 ID:SGTC_3346|Compound:9158254|FD-Score:2.98|P-value:3.01E-4

Top fitness defect scores for YDR247W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 5.50 10.0 µM 9.12E-11 69 1.88E-8
2 SGTC_2930 9013230 4.98 14.9 µM 3.91E-9 heme biosynthesis & mitochondrial translocase 15 3.10E-7
3 SGTC_2292 7671323 4.36 168.1 µM 2.29E-7 RNA processing & uracil transport 20 6.51E-6
4 SGTC_3217 9129673 4.31 49.5 µM 3.08E-7 26 8.12E-6
5 SGTC_922 1866-0035 4.24 480.0 µM 4.82E-7 excess fatty acid 43 1.14E-5
6 SGTC_1061 3448-9325 3.90 110.0 µM 3.28E-6 25 4.80E-5
7 SGTC_470 aa-861 3.80 153.0 µM 5.75E-6 sphingolipid biosynthesis & PDR1 63 7.31E-5
8 SGTC_1101 ebselen 3.79 5.3 µM 6.01E-6 30 7.56E-5
9 SGTC_476 mead acid 3.74 10.0 µM 7.66E-6 4 9.07E-5
10 SGTC_2303 7774051 3.64 200.0 µM 1.32E-5 31 1.37E-4
11 SGTC_2919 7978188 3.59 46.4 µM 1.67E-5 31 1.63E-4
12 SGTC_457 grayanotoxin iii 3.37 135.0 µM 4.96E-5 108 3.70E-4
13 SGTC_1364 1653-0028 3.34 37.6 µM 5.72E-5 44 4.13E-4
14 SGTC_263 alizarin 3.33 107.9 µM 6.16E-5 iron homeostasis 97 4.37E-4
15 SGTC_1413 3910-0535 3.32 34.4 µM 6.46E-5 29 4.52E-4
16 SGTC_2894 9048625 3.29 32.5 µM 7.42E-5 33 5.02E-4
17 SGTC_3061 glucosamine 3.23 200.0 µM 9.83E-5 28 6.21E-4
18 SGTC_1501 4491-0275 3.22 38.4 µM 1.02E-4 28 6.38E-4
19 SGTC_431 k089-0097 3.18 107.0 µM 1.22E-4 iron homeostasis 78 7.31E-4
20 SGTC_1411 3909-8223 3.17 150.0 µM 1.27E-4 33 7.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 6.07E-30 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.145 3.67E-17 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.90E-15 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.131 2.48E-14 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.130 4.42E-14 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.128 1.23E-13 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.126 3.09E-13 YOL135C MED7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.123 8.31E-13 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.123 1.02E-12 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.113 4.83E-11 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.108 3.71E-10 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.107 5.98E-10 YDR329C PEX3 hom Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
0.103 2.24E-9 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.102 2.95E-9 YGL132W_d YGL132W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
0.102 3.46E-9 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats