YDR248C_p

Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR248C / YDR248C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.94|P-value:7.51E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.88|P-value:9.37E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-6.84|P-value:6.98E-14 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.11|P-value:3.96E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:4.16|P-value:3.41E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.79|P-value:2.12E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.35|P-value:1.45E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.23|P-value:2.42E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:2.98|P-value:6.32E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.10|P-value:4.04E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.49|P-value:8.27E-5 ID:SGTC_499|Compound:genistein|FD-Score:2.99|P-value:6.23E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-4.47|P-value:6.63E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.36|P-value:1.40E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:2.94|P-value:7.38E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.07|P-value:4.58E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.55|P-value:4.35E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.49|P-value:1.45E-9 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.41|P-value:9.52E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.13|P-value:3.53E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.92|P-value:8.00E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.04|P-value:2.52E-8 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.00|P-value:7.63E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_1644|Compound:st010134|FD-Score:-3.08|P-value:4.38E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-3.24|P-value:2.32E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.56|P-value:4.15E-7 ID:SGTC_1977|Compound:st070720|FD-Score:3.07|P-value:4.61E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.57|P-value:5.63E-5 ID:SGTC_2119|Compound:5528445|FD-Score:2.98|P-value:6.49E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.49|P-value:8.28E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.07|P-value:4.54E-4 ID:SGTC_2426|Compound:5582046|FD-Score:5.40|P-value:2.64E-9 ID:SGTC_2429|Compound:5902844|FD-Score:3.64|P-value:4.17E-5 ID:SGTC_2435|Compound:5706476|FD-Score:2.94|P-value:7.39E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.79|P-value:2.13E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.81|P-value:1.90E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.35|P-value:1.45E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.13|P-value:3.50E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.49|P-value:7.87E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:2.94|P-value:7.38E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.62|P-value:4.45E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.24|P-value:2.36E-4 ID:SGTC_2792|Compound:7535235|FD-Score:6.46|P-value:1.48E-12 ID:SGTC_2851|Compound:9015922|FD-Score:2.96|P-value:6.90E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.02|P-value:5.53E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.42|P-value:1.10E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.14|P-value:3.49E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.96|P-value:6.82E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.19|P-value:2.81E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.94|P-value:7.51E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.88|P-value:9.37E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-6.84|P-value:6.98E-14 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.11|P-value:3.96E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:4.16|P-value:3.41E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:3.79|P-value:2.12E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.06|P-value:4.73E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.35|P-value:1.45E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.23|P-value:2.42E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:2.98|P-value:6.32E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.10|P-value:4.04E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.49|P-value:8.27E-5 ID:SGTC_499|Compound:genistein|FD-Score:2.99|P-value:6.23E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-4.47|P-value:6.63E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:-3.36|P-value:1.40E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:2.94|P-value:7.38E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.07|P-value:4.58E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.55|P-value:4.35E-7 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.49|P-value:1.45E-9 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.41|P-value:9.52E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.13|P-value:3.53E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:2.92|P-value:8.00E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:5.04|P-value:2.52E-8 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-4.00|P-value:7.63E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.35|P-value:1.46E-4 ID:SGTC_1644|Compound:st010134|FD-Score:-3.08|P-value:4.38E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-3.24|P-value:2.32E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.56|P-value:4.15E-7 ID:SGTC_1977|Compound:st070720|FD-Score:3.07|P-value:4.61E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.57|P-value:5.63E-5 ID:SGTC_2119|Compound:5528445|FD-Score:2.98|P-value:6.49E-4 ID:SGTC_2275|Compound:7947463|FD-Score:3.49|P-value:8.28E-5 ID:SGTC_2329|Compound:6138490|FD-Score:3.07|P-value:4.54E-4 ID:SGTC_2426|Compound:5582046|FD-Score:5.40|P-value:2.64E-9 ID:SGTC_2429|Compound:5902844|FD-Score:3.64|P-value:4.17E-5 ID:SGTC_2435|Compound:5706476|FD-Score:2.94|P-value:7.39E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.79|P-value:2.13E-5 ID:SGTC_2461|Compound:5755302|FD-Score:3.81|P-value:1.90E-5 ID:SGTC_2475|Compound:5812728|FD-Score:-3.35|P-value:1.45E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.13|P-value:3.50E-4 ID:SGTC_2488|Compound:5268135|FD-Score:-3.49|P-value:7.87E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:2.94|P-value:7.38E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.62|P-value:4.45E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:3.24|P-value:2.36E-4 ID:SGTC_2792|Compound:7535235|FD-Score:6.46|P-value:1.48E-12 ID:SGTC_2851|Compound:9015922|FD-Score:2.96|P-value:6.90E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.04|P-value:5.03E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.02|P-value:5.53E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.42|P-value:1.10E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.14|P-value:3.49E-4 ID:SGTC_3306|Compound:9127676|FD-Score:2.96|P-value:6.82E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-3.19|P-value:2.81E-4

Top fitness defect scores for YDR248C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2792 7535235 6.46 81.8 µM 1.48E-12 fatty acid desaturase (OLE1) 8 5.31E-11
2 SGTC_1003 4049-0218 5.49 100.0 µM 1.45E-9 5 1.97E-8
3 SGTC_2426 5582046 5.40 32.2 µM 2.64E-9 7 3.30E-8
4 SGTC_1261 0712-0010 5.04 12.7 µM 2.52E-8 RNA processing & uracil transport 9 2.29E-7
5 SGTC_1779 st039427 4.56 55.0 µM 4.15E-7 12 2.55E-6
6 SGTC_994 3910-0338 4.55 138.0 µM 4.35E-7 calcium & mitochondrial duress 27 2.66E-6
7 SGTC_1166 k206-0078 4.41 225.0 µM 9.52E-7 14 5.22E-6
8 SGTC_155 k072-0202 4.16 43.6 µM 3.41E-6 14 1.57E-5
9 SGTC_2461 5755302 3.81 26.1 µM 1.90E-5 37 6.89E-5
10 SGTC_159 3970-0959 3.79 50.0 µM 2.12E-5 83 7.56E-5
11 SGTC_2429 5902844 3.64 64.4 µM 4.17E-5 35 1.36E-4
12 SGTC_374 0880-0231 3.49 82.3 µM 8.27E-5 iron homeostasis 39 2.45E-4
13 SGTC_2275 7947463 3.49 200.0 µM 8.28E-5 iron homeostasis 53 2.45E-4
14 SGTC_3284 9108171 3.42 64.9 µM 1.10E-4 39 3.13E-4
15 SGTC_2760 etidronate 3.24 98.0 µM 2.36E-4 57 6.06E-4
16 SGTC_212 3807-4682 3.23 38.8 µM 2.42E-4 tubulin folding & SWR complex 116 6.20E-4
17 SGTC_3300 9124615 3.14 50.5 µM 3.49E-4 53 8.50E-4
18 SGTC_1239 0337-0584 3.13 35.4 µM 3.53E-4 unfolded protein response 97 8.60E-4
19 SGTC_102 gallobenzophenone 3.11 83.6 µM 3.96E-4 redox potentiating 72 9.49E-4
20 SGTC_335 4077-0256 3.10 27.6 µM 4.04E-4 38 9.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.03E-14 YPL073C_d YPL073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments
0.128 9.19E-14 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.118 7.48E-12 YDR242W AMD2 hom Putative amidase
0.095 3.13E-8 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.093 6.11E-8 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.093 6.45E-8 YLR138W NHA1 hom Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
0.091 1.34E-7 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.087 4.05E-7 YGR176W_d YGR176W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.57E-7 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.084 9.63E-7 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.084 9.92E-7 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.084 1.17E-6 YIR005W IST3 hom Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
0.083 1.51E-6 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.083 1.63E-6 YGL196W DSD1 hom D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate
0.083 1.68E-6 YDR263C DIN7 hom Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination