YDR249C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR249C / YDR249C

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-3.02|P-value:3.23E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.17|P-value:1.71E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.86|P-value:8.99E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.61|P-value:3.78E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.18|P-value:2.21E-6 ID:SGTC_229|Compound:benomyl|FD-Score:3.78|P-value:1.71E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-2.84|P-value:6.47E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-3.16|P-value:1.76E-4 ID:SGTC_490|Compound:phenamil|FD-Score:2.88|P-value:8.40E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.28|P-value:1.65E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:2.86|P-value:8.94E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.10|P-value:1.99E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:3.00|P-value:5.31E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.88|P-value:1.06E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.85|P-value:6.29E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.24|P-value:1.60E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:3.08|P-value:3.78E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-2.73|P-value:9.70E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:-2.86|P-value:5.98E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.16|P-value:2.50E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.10|P-value:3.37E-6 ID:SGTC_1683|Compound:st010134|FD-Score:-3.54|P-value:3.30E-5 ID:SGTC_1726|Compound:st035556|FD-Score:2.98|P-value:5.70E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.63|P-value:3.49E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.63|P-value:3.55E-5 ID:SGTC_1845|Compound:st056753|FD-Score:-3.93|P-value:4.81E-6 ID:SGTC_1855|Compound:st056195|FD-Score:2.91|P-value:7.53E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.90|P-value:7.79E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.27|P-value:1.12E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.83|P-value:1.32E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.25|P-value:1.21E-4 ID:SGTC_2310|Compound:7668677|FD-Score:5.56|P-value:4.74E-10 ID:SGTC_2352|Compound:9027995|FD-Score:3.01|P-value:5.12E-4 ID:SGTC_2427|Compound:5545055|FD-Score:2.96|P-value:6.23E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.22|P-value:1.35E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.72|P-value:2.26E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.65|P-value:8.70E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.12|P-value:3.25E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.63|P-value:3.49E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.99|P-value:5.59E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:2.95|P-value:6.38E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-5.55|P-value:2.31E-10 ID:SGTC_2987|Compound:9018338|FD-Score:-2.85|P-value:6.34E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.39|P-value:1.06E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-4.18|P-value:1.27E-6 ID:SGTC_3090|Compound:9117696|FD-Score:3.43|P-value:8.93E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.13|P-value:3.16E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.22|P-value:2.19E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.02|P-value:3.23E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.17|P-value:1.71E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.86|P-value:8.99E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.61|P-value:3.78E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.18|P-value:2.21E-6 ID:SGTC_229|Compound:benomyl|FD-Score:3.78|P-value:1.71E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-2.84|P-value:6.47E-4 ID:SGTC_484|Compound:loperamide|FD-Score:-3.16|P-value:1.76E-4 ID:SGTC_490|Compound:phenamil|FD-Score:2.88|P-value:8.40E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.28|P-value:1.65E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:2.86|P-value:8.94E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.10|P-value:1.99E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:3.00|P-value:5.31E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.88|P-value:1.06E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.85|P-value:6.29E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.24|P-value:1.60E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:3.08|P-value:3.78E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-2.73|P-value:9.70E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:-2.86|P-value:5.98E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.16|P-value:2.50E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.10|P-value:3.37E-6 ID:SGTC_1683|Compound:st010134|FD-Score:-3.54|P-value:3.30E-5 ID:SGTC_1726|Compound:st035556|FD-Score:2.98|P-value:5.70E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.63|P-value:3.49E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.63|P-value:3.55E-5 ID:SGTC_1845|Compound:st056753|FD-Score:-3.93|P-value:4.81E-6 ID:SGTC_1855|Compound:st056195|FD-Score:2.91|P-value:7.53E-4 ID:SGTC_1913|Compound:st060213|FD-Score:2.90|P-value:7.79E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.27|P-value:1.12E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.83|P-value:1.32E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-3.25|P-value:1.21E-4 ID:SGTC_2310|Compound:7668677|FD-Score:5.56|P-value:4.74E-10 ID:SGTC_2352|Compound:9027995|FD-Score:3.01|P-value:5.12E-4 ID:SGTC_2427|Compound:5545055|FD-Score:2.96|P-value:6.23E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-3.22|P-value:1.35E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.72|P-value:2.26E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.65|P-value:8.70E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.12|P-value:3.25E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.63|P-value:3.49E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:2.99|P-value:5.59E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:2.95|P-value:6.38E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-5.55|P-value:2.31E-10 ID:SGTC_2987|Compound:9018338|FD-Score:-2.85|P-value:6.34E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.39|P-value:1.06E-4 ID:SGTC_3075|Compound:9116269|FD-Score:-4.18|P-value:1.27E-6 ID:SGTC_3090|Compound:9117696|FD-Score:3.43|P-value:8.93E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.13|P-value:3.16E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.22|P-value:2.19E-4

Top fitness defect scores for YDR249C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2310 7668677 5.56 200.0 µM 4.74E-10 7 1.36E-8
2 SGTC_923 1900-2434 4.24 73.3 µM 1.60E-6 RNA processing & uracil transport 28 1.10E-5
3 SGTC_214 4373-3496 4.18 70.0 µM 2.21E-6 50 1.44E-5
4 SGTC_1503 4585-0012 4.16 61.3 µM 2.50E-6 11 1.59E-5
5 SGTC_1506 4226-2149 4.10 212.0 µM 3.37E-6 25 2.03E-5
6 SGTC_737 1950-0117 3.88 57.9 µM 1.06E-5 26 5.26E-5
7 SGTC_2119 5528445 3.83 120.6 µM 1.32E-5 21 6.31E-5
8 SGTC_229 benomyl 3.78 22.9 µM 1.71E-5 tubulin folding & SWR complex 34 7.80E-5
9 SGTC_2502 avocadyne acetate 3.72 18.6 µM 2.26E-5 31 9.82E-5
10 SGTC_2563 tomatine 3.63 8.5 µM 3.49E-5 67 1.41E-4
11 SGTC_1738 st035555 3.63 74.0 µM 3.49E-5 TSC3-RPN4 44 1.41E-4
12 SGTC_1823 3-hydroxy-2-naphthoic acid 3.63 106.0 µM 3.55E-5 25 1.43E-4
13 SGTC_212 3807-4682 3.61 38.8 µM 3.78E-5 tubulin folding & SWR complex 88 1.50E-4
14 SGTC_3090 9117696 3.43 49.5 µM 8.93E-5 23 3.07E-4
15 SGTC_2989 9073649 3.39 71.4 µM 1.06E-4 63 3.55E-4
16 SGTC_513 4245-1575 3.28 41.7 µM 1.65E-4 unfolded protein response 165 5.12E-4
17 SGTC_3291 9121177 3.22 71.4 µM 2.19E-4 31 6.48E-4
18 SGTC_3093 9117344 3.13 49.5 µM 3.16E-4 60S ribosome export 53 8.80E-4
19 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.12 92.6 µM 3.25E-4 62 9.00E-4
20 SGTC_925 2064-1272 3.08 59.6 µM 3.78E-4 62 0.00102

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.67E-14 YJR020W_d YJR020W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 1.87E-12 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.119 4.74E-12 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.112 8.51E-11 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.106 7.65E-10 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.106 8.10E-10 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.106 8.20E-10 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.102 3.56E-9 YJR154W_p YJR154W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.099 7.99E-9 YGR161C_p RTS3_p hom Putative component of the protein phosphatase type 2A complex
0.097 1.70E-8 YOR137C SIA1 hom Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose
0.096 2.66E-8 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.089 2.72E-7 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.087 4.47E-7 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.087 4.79E-7 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.083 1.44E-6 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome