Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.132 |
1.67E-14 |
YJR020W_d |
YJR020W_d |
hom |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.121 |
1.87E-12 |
YER007W |
PAC2 |
hom |
Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl |
0.119 |
4.74E-12 |
YOL012C |
HTZ1 |
hom |
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin |
0.112 |
8.51E-11 |
YPL241C |
CIN2 |
hom |
GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 |
0.106 |
7.65E-10 |
YDR001C |
NTH1 |
hom |
Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication |
0.106 |
8.10E-10 |
YBL034C |
STU1 |
het |
Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles |
0.106 |
8.20E-10 |
YNL313C |
EMW1 |
het |
Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress |
0.102 |
3.56E-9 |
YJR154W_p |
YJR154W_p |
hom |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
0.099 |
7.99E-9 |
YGR161C_p |
RTS3_p |
hom |
Putative component of the protein phosphatase type 2A complex |
0.097 |
1.70E-8 |
YOR137C |
SIA1 |
hom |
Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose |
0.096 |
2.66E-8 |
YNR033W |
ABZ1 |
hom |
Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress |
0.089 |
2.72E-7 |
YDR212W |
TCP1 |
het |
Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
0.087 |
4.47E-7 |
YGR292W |
MAL12 |
hom |
Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose |
0.087 |
4.79E-7 |
YJR064W |
CCT5 |
het |
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
0.083 |
1.44E-6 |
YGR108W |
CLB1 |
hom |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |