YDR260C / SWM1

Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR260C / SWM1

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:4.57|P-value:3.06E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.27|P-value:1.10E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.18|P-value:1.74E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:12.70|P-value:1.64E-36 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:12.20|P-value:4.33E-34 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:16.10|P-value:9.94E-58 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:14.10|P-value:6.94E-45 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:9.77|P-value:1.94E-22 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:18.70|P-value:1.30E-76 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.27|P-value:6.09E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.41|P-value:4.37E-8 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.97|P-value:4.35E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.63|P-value:2.32E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:4.90|P-value:6.30E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.66|P-value:2.04E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:14.20|P-value:3.40E-45 ID:SGTC_925|Compound:2064-1272|FD-Score:3.15|P-value:9.17E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.69|P-value:1.29E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.10|P-value:2.47E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.26|P-value:9.45E-8 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.68|P-value:1.30E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-4.92|P-value:5.03E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.02|P-value:3.43E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.36|P-value:4.42E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.02|P-value:3.45E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.13|P-value:1.93E-7 ID:SGTC_2283|Compound:7944793|FD-Score:-3.24|P-value:6.44E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.71|P-value:3.16E-18 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.37|P-value:4.12E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.90|P-value:6.14E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.67|P-value:1.34E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.18|P-value:1.74E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.36|P-value:4.41E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.19|P-value:8.17E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.18|P-value:8.25E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.66|P-value:1.49E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.18|P-value:8.27E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.49|P-value:2.83E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-5.12|P-value:1.82E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-4.66|P-value:1.88E-6 ID:SGTC_3083|Compound:9117465|FD-Score:4.06|P-value:2.90E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.47|P-value:2.80E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.35|P-value:4.56E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.14|P-value:2.08E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-5.49|P-value:2.54E-8 ID:SGTC_3305|Compound:9127027|FD-Score:8.31|P-value:9.12E-17 ID:SGTC_3307|Compound:9126885|FD-Score:-5.38|P-value:4.57E-8 ID:SGTC_3315|Compound:9136395|FD-Score:3.58|P-value:1.98E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.57|P-value:3.06E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-4.27|P-value:1.10E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:4.18|P-value:1.74E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:12.70|P-value:1.64E-36 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:12.20|P-value:4.33E-34 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:16.10|P-value:9.94E-58 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:14.10|P-value:6.94E-45 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:9.77|P-value:1.94E-22 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:18.70|P-value:1.30E-76 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.27|P-value:6.09E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.41|P-value:4.37E-8 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.97|P-value:4.35E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.63|P-value:2.32E-6 ID:SGTC_428|Compound:3448-4153|FD-Score:4.90|P-value:6.30E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.66|P-value:2.04E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:14.20|P-value:3.40E-45 ID:SGTC_925|Compound:2064-1272|FD-Score:3.15|P-value:9.17E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.69|P-value:1.29E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:4.10|P-value:2.47E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.26|P-value:9.45E-8 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.68|P-value:1.30E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-4.92|P-value:5.03E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.02|P-value:3.43E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.36|P-value:4.42E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.02|P-value:3.45E-5 ID:SGTC_2006|Compound:4011487|FD-Score:5.13|P-value:1.93E-7 ID:SGTC_2283|Compound:7944793|FD-Score:-3.24|P-value:6.44E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.71|P-value:3.16E-18 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.37|P-value:4.12E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.90|P-value:6.14E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.67|P-value:1.34E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.18|P-value:8.26E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.18|P-value:1.74E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.36|P-value:4.41E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:3.19|P-value:8.17E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.18|P-value:8.25E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.66|P-value:1.49E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.18|P-value:8.27E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.49|P-value:2.83E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-5.12|P-value:1.82E-7 ID:SGTC_2945|Compound:9067681|FD-Score:-4.66|P-value:1.88E-6 ID:SGTC_3083|Compound:9117465|FD-Score:4.06|P-value:2.90E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-3.47|P-value:2.80E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.68|P-value:1.38E-4 ID:SGTC_3247|Compound:9135149|FD-Score:3.35|P-value:4.56E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.14|P-value:2.08E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-5.49|P-value:2.54E-8 ID:SGTC_3305|Compound:9127027|FD-Score:8.31|P-value:9.12E-17 ID:SGTC_3307|Compound:9126885|FD-Score:-5.38|P-value:4.57E-8 ID:SGTC_3315|Compound:9136395|FD-Score:3.58|P-value:1.98E-4

Top fitness defect scores for YDR260C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_243 5hr heat shock (37°C) + splitomicin 18.70 1.0 µM 1.30E-76 heat shock/prefoldin 3 5.64E-78
2 SGTC_240 5hr heat shock (37°C) + Streptovitacin 16.10 300.0 µM 9.94E-58 heat shock/prefoldin 3 9.34E-59
3 SGTC_514 4466-0038 14.20 2.6 nM 3.40E-45 cell wall 10 5.35E-46
4 SGTC_241 5hr heat shock (37°C) + cantharidin 14.10 155.4 µM 6.94E-45 cell wall signaling 5 1.11E-45
5 SGTC_238 5hr heat shock (37°C) + nsc-638432 12.70 8.9 µM 1.64E-36 heat shock/prefoldin 3 3.71E-37
6 SGTC_239 5hr heat shock (37°C) + mitomycin C 12.20 819.4 µM 4.33E-34 heat shock/prefoldin 3 1.08E-34
7 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 9.77 4.6 µM 1.94E-22 heat shock/prefoldin 6 7.82E-23
8 SGTC_2405 ticlatone 8.71 3.5 µM 3.16E-18 15 1.52E-18
9 SGTC_3305 9127027 8.31 53.8 µM 9.12E-17 1 4.67E-17
10 SGTC_268 camptothecin 5.41 39.6 µM 4.37E-8 DNA damage response 38 3.22E-8
11 SGTC_1009 4106-0057 5.26 9.9 µM 9.45E-8 3 7.07E-8
12 SGTC_2006 4011487 5.13 200.0 µM 1.93E-7 endomembrane recycling 59 1.47E-7
13 SGTC_2413 inermin 4.90 26.1 µM 6.14E-7 33 4.76E-7
14 SGTC_428 3448-4153 4.90 16.5 µM 6.30E-7 TSC3-RPN4 17 4.88E-7
15 SGTC_503 tyrphostin 8 4.66 294.0 µM 2.04E-6 TSC3-RPN4 11 1.62E-6
16 SGTC_426 0988-0037 4.63 14.6 µM 2.32E-6 ERAD & cell cycle 20 1.84E-6
17 SGTC_71 0417-1750 4.57 47.8 µM 3.06E-6 Golgi 31 2.44E-6
18 SGTC_212 3807-4682 4.18 38.8 µM 1.74E-5 tubulin folding & SWR complex 57 1.43E-5
19 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 4.18 63.6 µM 1.74E-5 33 1.44E-5
20 SGTC_3301 9125354 4.14 19.8 µM 2.08E-5 13 1.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.536 7.98E-249 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.408 4.25E-135 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.376 4.03E-113 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.344 1.05E-93 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.330 4.70E-86 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.275 1.70E-59 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.271 1.62E-57 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.266 2.67E-55 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.241 2.12E-45 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.229 3.72E-41 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.208 3.46E-34 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.203 1.98E-32 YCR077C PAT1 hom Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
0.199 2.13E-31 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.192 3.83E-29 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.190 1.41E-28 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication