HIPHOP chemogenomics database

YDR263C / DIN7

Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR263C / DIN7

Click on Significant Values for Screen Details

Top fitness defect scores for YDR263C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_473	2-arachidonoylglycerol	8.55	10.0 µM	2.65E-17		1	6.07E-18
2	SGTC_2969	9091408	7.85	28.7 µM	7.13E-15		1	2.03E-15
3	SGTC_2586	curcumin	6.22	80.0 µM	5.78E-10	iron homeostasis	13	2.55E-10
4	SGTC_2824	7998404	6.11	52.0 µM	1.09E-9		7	4.94E-10
5	SGTC_470	aa-861	5.72	153.0 µM	1.08E-8	sphingolipid biosynthesis & PDR1	25	5.32E-9
6	SGTC_214	4373-3496	5.30	70.0 µM	1.07E-7		22	5.76E-8
7	SGTC_2816	7982706	5.12	58.4 µM	2.66E-7	azole & statin	27	1.49E-7
8	SGTC_2967	9089538	5.04	49.9 µM	4.17E-7		10	2.38E-7
9	SGTC_2426	5582046	4.95	32.2 µM	6.44E-7		11	3.74E-7
10	SGTC_2760	etidronate	4.78	98.0 µM	1.44E-6		12	8.64E-7
11	SGTC_1230	0170-0365	4.42	3.8 µM	7.56E-6	endomembrane recycling	49	4.83E-6
12	SGTC_2675	theaflavin digallate	4.35	100.0 µM	1.04E-5	iron homeostasis	23	6.70E-6
13	SGTC_2817	7995342	4.05	71.4 µM	3.71E-5		21	2.52E-5
14	SGTC_472	calcifediol	4.02	10.0 µM	4.33E-5		4	2.96E-5
15	SGTC_1525	8-methoxypsoralen	3.99	92.5 µM	4.85E-5	DNA damage response	31	3.33E-5
16	SGTC_494	Boc-Gly-Val-Val-CHO	3.98	140.0 µM	4.95E-5		7	3.40E-5
17	SGTC_1348	1493-0373	3.94	93.8 µM	5.87E-5		14	4.07E-5
18	SGTC_2482	5981709	3.93	142.7 µM	6.09E-5	PDR1	37	4.22E-5
19	SGTC_1690	st023502	3.83	41.2 µM	9.11E-5	calcium & mitochondrial duress	11	6.41E-5
20	SGTC_457	grayanotoxin iii	3.83	135.0 µM	9.17E-5		76	6.46E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.135	4.58E-15	YDR271C_d	YDR271C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.118	7.47E-12	YLR281C_p	YLR281C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.118	7.96E-12	YDL112W	TRM3	hom	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.109	2.15E-10	YJR040W	GEF1	hom	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.108	4.12E-10	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.104	1.38E-9	YDR269C_d	YDR269C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094	5.65E-8	YDR274C_d	YDR274C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092	1.02E-7	YJL094C	KHA1	hom	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.088	3.56E-7	YNL092W_p	YNL092W_p	hom	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.085	8.65E-7	YLR251W	SYM1	hom	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.085	9.22E-7	YDR072C	IPT1	hom	Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.084	1.13E-6	YOR310C	NOP58	het	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.083	1.68E-6	YDR248C_p	YDR248C_p	hom	Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.082	2.09E-6	YDR270W	CCC2	hom	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.080	3.78E-6	YBR120C	CBP6	hom	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex