YDR263C / DIN7

Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR263C / DIN7

Click on Significant Values for Screen Details ID:SGTC_214|Compound:4373-3496|FD-Score:5.30|P-value:1.07E-7 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.27|P-value:6.15E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.95|P-value:4.89E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.41|P-value:4.28E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.33|P-value:5.67E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.23|P-value:8.11E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.83|P-value:9.17E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.72|P-value:1.08E-8 ID:SGTC_472|Compound:calcifediol|FD-Score:4.02|P-value:4.33E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:8.55|P-value:2.65E-17 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.84|P-value:7.52E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.98|P-value:4.95E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.52|P-value:2.56E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-4.30|P-value:1.12E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.45|P-value:3.31E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.28|P-value:5.98E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.17|P-value:9.84E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.44|P-value:3.85E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.82|P-value:8.25E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.33|P-value:5.05E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.34|P-value:5.53E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.42|P-value:7.56E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.22|P-value:7.33E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.35|P-value:4.66E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.22|P-value:7.33E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.94|P-value:5.87E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.99|P-value:4.85E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.41|P-value:4.26E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.83|P-value:9.11E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:3.74|P-value:1.28E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.69|P-value:1.58E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.94|P-value:5.01E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.29|P-value:6.56E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.26|P-value:6.44E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.17|P-value:9.70E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.93|P-value:5.23E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.98|P-value:4.24E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.95|P-value:6.44E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.93|P-value:6.09E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:6.22|P-value:5.78E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-5.53|P-value:2.50E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.35|P-value:1.04E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.93|P-value:5.36E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.51|P-value:2.61E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.18|P-value:8.38E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.78|P-value:1.44E-6 ID:SGTC_2816|Compound:7982706|FD-Score:5.12|P-value:2.66E-7 ID:SGTC_2817|Compound:7995342|FD-Score:4.05|P-value:3.71E-5 ID:SGTC_2824|Compound:7998404|FD-Score:6.11|P-value:1.09E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-3.46|P-value:3.18E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.23|P-value:7.01E-4 ID:SGTC_2967|Compound:9089538|FD-Score:5.04|P-value:4.17E-7 ID:SGTC_2968|Compound:9090663|FD-Score:3.77|P-value:1.16E-4 ID:SGTC_2969|Compound:9091408|FD-Score:7.85|P-value:7.13E-15 ID:SGTC_2972|Compound:9093619|FD-Score:3.79|P-value:1.07E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.68|P-value:1.39E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-4.13|P-value:2.33E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-5.18|P-value:1.67E-7 ID:SGTC_214|Compound:4373-3496|FD-Score:5.30|P-value:1.07E-7 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.27|P-value:6.15E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.95|P-value:4.89E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.41|P-value:4.28E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.33|P-value:5.67E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.23|P-value:8.11E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.83|P-value:9.17E-5 ID:SGTC_470|Compound:aa-861|FD-Score:5.72|P-value:1.08E-8 ID:SGTC_472|Compound:calcifediol|FD-Score:4.02|P-value:4.33E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:8.55|P-value:2.65E-17 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.84|P-value:7.52E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.98|P-value:4.95E-5 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.52|P-value:2.56E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-4.30|P-value:1.12E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:-3.45|P-value:3.31E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.28|P-value:5.98E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.17|P-value:9.84E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.44|P-value:3.85E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.82|P-value:8.25E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.33|P-value:5.05E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.34|P-value:5.53E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:4.42|P-value:7.56E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.22|P-value:7.33E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.35|P-value:4.66E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:-3.22|P-value:7.33E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.94|P-value:5.87E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.30|P-value:6.28E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.99|P-value:4.85E-5 ID:SGTC_1621|Compound:st003705|FD-Score:3.41|P-value:4.26E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.83|P-value:9.11E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:3.74|P-value:1.28E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.69|P-value:1.58E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.94|P-value:5.01E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.29|P-value:6.56E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.26|P-value:6.44E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.17|P-value:9.70E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.93|P-value:5.23E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.98|P-value:4.24E-5 ID:SGTC_2426|Compound:5582046|FD-Score:4.95|P-value:6.44E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.93|P-value:6.09E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.76|P-value:1.19E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:6.22|P-value:5.78E-10 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-5.53|P-value:2.50E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.35|P-value:1.04E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.93|P-value:5.36E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.51|P-value:2.61E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.18|P-value:8.38E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:4.78|P-value:1.44E-6 ID:SGTC_2816|Compound:7982706|FD-Score:5.12|P-value:2.66E-7 ID:SGTC_2817|Compound:7995342|FD-Score:4.05|P-value:3.71E-5 ID:SGTC_2824|Compound:7998404|FD-Score:6.11|P-value:1.09E-9 ID:SGTC_2835|Compound:9006588|FD-Score:-3.46|P-value:3.18E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-3.23|P-value:7.01E-4 ID:SGTC_2967|Compound:9089538|FD-Score:5.04|P-value:4.17E-7 ID:SGTC_2968|Compound:9090663|FD-Score:3.77|P-value:1.16E-4 ID:SGTC_2969|Compound:9091408|FD-Score:7.85|P-value:7.13E-15 ID:SGTC_2972|Compound:9093619|FD-Score:3.79|P-value:1.07E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-3.68|P-value:1.39E-4 ID:SGTC_3245|Compound:9134821|FD-Score:-4.13|P-value:2.33E-5 ID:SGTC_3254|Compound:9136651|FD-Score:-5.18|P-value:1.67E-7

Top fitness defect scores for YDR263C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_473 2-arachidonoylglycerol 8.55 10.0 µM 2.65E-17 1 6.07E-18
2 SGTC_2969 9091408 7.85 28.7 µM 7.13E-15 1 2.03E-15
3 SGTC_2586 curcumin 6.22 80.0 µM 5.78E-10 iron homeostasis 13 2.55E-10
4 SGTC_2824 7998404 6.11 52.0 µM 1.09E-9 7 4.94E-10
5 SGTC_470 aa-861 5.72 153.0 µM 1.08E-8 sphingolipid biosynthesis & PDR1 25 5.32E-9
6 SGTC_214 4373-3496 5.30 70.0 µM 1.07E-7 22 5.76E-8
7 SGTC_2816 7982706 5.12 58.4 µM 2.66E-7 azole & statin 27 1.49E-7
8 SGTC_2967 9089538 5.04 49.9 µM 4.17E-7 10 2.38E-7
9 SGTC_2426 5582046 4.95 32.2 µM 6.44E-7 11 3.74E-7
10 SGTC_2760 etidronate 4.78 98.0 µM 1.44E-6 12 8.64E-7
11 SGTC_1230 0170-0365 4.42 3.8 µM 7.56E-6 endomembrane recycling 49 4.83E-6
12 SGTC_2675 theaflavin digallate 4.35 100.0 µM 1.04E-5 iron homeostasis 23 6.70E-6
13 SGTC_2817 7995342 4.05 71.4 µM 3.71E-5 21 2.52E-5
14 SGTC_472 calcifediol 4.02 10.0 µM 4.33E-5 4 2.96E-5
15 SGTC_1525 8-methoxypsoralen 3.99 92.5 µM 4.85E-5 DNA damage response 31 3.33E-5
16 SGTC_494 Boc-Gly-Val-Val-CHO 3.98 140.0 µM 4.95E-5 7 3.40E-5
17 SGTC_1348 1493-0373 3.94 93.8 µM 5.87E-5 14 4.07E-5
18 SGTC_2482 5981709 3.93 142.7 µM 6.09E-5 PDR1 37 4.22E-5
19 SGTC_1690 st023502 3.83 41.2 µM 9.11E-5 calcium & mitochondrial duress 11 6.41E-5
20 SGTC_457 grayanotoxin iii 3.83 135.0 µM 9.17E-5 76 6.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.58E-15 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.118 7.47E-12 YLR281C_p YLR281C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.118 7.96E-12 YDL112W TRM3 hom 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.109 2.15E-10 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.108 4.12E-10 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.104 1.38E-9 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.65E-8 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 1.02E-7 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.088 3.56E-7 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.085 8.65E-7 YLR251W SYM1 hom Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
0.085 9.22E-7 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.084 1.13E-6 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.083 1.68E-6 YDR248C_p YDR248C_p hom Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.082 2.09E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.080 3.78E-6 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex