YDR264C / AKR1

Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR264C / AKR1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:5.71|P-value:7.82E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.49|P-value:3.30E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:7.87|P-value:8.23E-12 ID:SGTC_205|Compound:1486-1330|FD-Score:4.33|P-value:1.80E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.99|P-value:5.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.92|P-value:6.74E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.92|P-value:6.68E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.88|P-value:1.71E-6 ID:SGTC_317|Compound:4495-0002|FD-Score:3.88|P-value:7.60E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.24|P-value:2.40E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.94|P-value:6.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.47|P-value:3.51E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.79|P-value:3.46E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:5.43|P-value:2.66E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.11|P-value:3.65E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.85|P-value:2.67E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:5.39|P-value:3.07E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:4.56|P-value:7.96E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.93|P-value:6.43E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.27|P-value:2.17E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.19|P-value:7.17E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.47|P-value:1.09E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.82|P-value:9.20E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.81|P-value:3.15E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.91|P-value:7.03E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.44|P-value:1.22E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.46|P-value:1.14E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.87|P-value:3.74E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.83|P-value:2.89E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.05|P-value:4.43E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.16|P-value:3.12E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.05|P-value:4.39E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.81|P-value:4.97E-7 ID:SGTC_1627|Compound:st003713|FD-Score:4.70|P-value:4.82E-5 ID:SGTC_1634|Compound:st006576|FD-Score:-3.84|P-value:9.84E-5 ID:SGTC_1636|Compound:st007707|FD-Score:7.18|P-value:4.89E-10 ID:SGTC_1656|Compound:st012921|FD-Score:3.84|P-value:8.67E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.83|P-value:8.77E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.05|P-value:4.47E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.89|P-value:7.40E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.36|P-value:1.62E-4 ID:SGTC_1970|Compound:st070122|FD-Score:5.03|P-value:1.34E-5 ID:SGTC_2026|Compound:5148700|FD-Score:4.49|P-value:1.01E-4 ID:SGTC_2084|Compound:5306078|FD-Score:5.81|P-value:5.02E-7 ID:SGTC_2105|Compound:5350118|FD-Score:4.43|P-value:1.27E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.91|P-value:7.01E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.79|P-value:9.96E-4 ID:SGTC_2376|Compound:9072922|FD-Score:5.17|P-value:7.70E-6 ID:SGTC_2384|Compound:9036245|FD-Score:4.76|P-value:3.79E-5 ID:SGTC_2450|Compound:5739737|FD-Score:5.70|P-value:8.29E-7 ID:SGTC_2526|Compound:patulin|FD-Score:4.25|P-value:2.30E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.54|P-value:6.96E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.75|P-value:3.93E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.08|P-value:1.09E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.11|P-value:3.70E-4 ID:SGTC_2800|Compound:7887935|FD-Score:6.33|P-value:4.26E-8 ID:SGTC_2887|Compound:9044784|FD-Score:4.15|P-value:3.25E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.10|P-value:3.75E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.78|P-value:3.56E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.87|P-value:7.90E-4 ID:SGTC_3244|Compound:9134489|FD-Score:5.51|P-value:1.83E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.96|P-value:5.98E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.71|P-value:7.82E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.49|P-value:3.30E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:7.87|P-value:8.23E-12 ID:SGTC_205|Compound:1486-1330|FD-Score:4.33|P-value:1.80E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.99|P-value:5.35E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.92|P-value:6.74E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.92|P-value:6.68E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.88|P-value:1.71E-6 ID:SGTC_317|Compound:4495-0002|FD-Score:3.88|P-value:7.60E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:4.24|P-value:2.40E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.94|P-value:6.27E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.47|P-value:3.51E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:4.79|P-value:3.46E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:5.43|P-value:2.66E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.11|P-value:3.65E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.85|P-value:2.67E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:5.39|P-value:3.07E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:4.56|P-value:7.96E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.93|P-value:6.43E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:4.27|P-value:2.17E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.19|P-value:7.17E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.47|P-value:1.09E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.82|P-value:9.20E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.81|P-value:3.15E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.91|P-value:7.03E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.44|P-value:1.22E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:4.46|P-value:1.14E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.87|P-value:3.74E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.83|P-value:2.89E-5 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.05|P-value:4.43E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.16|P-value:3.12E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:4.05|P-value:4.39E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:5.81|P-value:4.97E-7 ID:SGTC_1627|Compound:st003713|FD-Score:4.70|P-value:4.82E-5 ID:SGTC_1634|Compound:st006576|FD-Score:-3.84|P-value:9.84E-5 ID:SGTC_1636|Compound:st007707|FD-Score:7.18|P-value:4.89E-10 ID:SGTC_1656|Compound:st012921|FD-Score:3.84|P-value:8.67E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.83|P-value:8.77E-4 ID:SGTC_1909|Compound:st060837|FD-Score:4.05|P-value:4.47E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.89|P-value:7.40E-4 ID:SGTC_1956|Compound:st077085|FD-Score:4.36|P-value:1.62E-4 ID:SGTC_1970|Compound:st070122|FD-Score:5.03|P-value:1.34E-5 ID:SGTC_2026|Compound:5148700|FD-Score:4.49|P-value:1.01E-4 ID:SGTC_2084|Compound:5306078|FD-Score:5.81|P-value:5.02E-7 ID:SGTC_2105|Compound:5350118|FD-Score:4.43|P-value:1.27E-4 ID:SGTC_2243|Compound:6634756|FD-Score:3.91|P-value:7.01E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.79|P-value:9.96E-4 ID:SGTC_2376|Compound:9072922|FD-Score:5.17|P-value:7.70E-6 ID:SGTC_2384|Compound:9036245|FD-Score:4.76|P-value:3.79E-5 ID:SGTC_2450|Compound:5739737|FD-Score:5.70|P-value:8.29E-7 ID:SGTC_2526|Compound:patulin|FD-Score:4.25|P-value:2.30E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-4.54|P-value:6.96E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.75|P-value:3.93E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:5.08|P-value:1.09E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.11|P-value:3.70E-4 ID:SGTC_2800|Compound:7887935|FD-Score:6.33|P-value:4.26E-8 ID:SGTC_2887|Compound:9044784|FD-Score:4.15|P-value:3.25E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.10|P-value:3.75E-4 ID:SGTC_2999|Compound:9069765|FD-Score:4.78|P-value:3.56E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.87|P-value:7.90E-4 ID:SGTC_3244|Compound:9134489|FD-Score:5.51|P-value:1.83E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.96|P-value:5.98E-4

Top fitness defect scores for YDR264C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_121 0557-0495 7.87 61.3 µM 8.23E-12 calcium & mitochondrial duress 10 1.74E-15
2 SGTC_1636 st007707 7.18 68.9 µM 4.89E-10 14 3.58E-13
3 SGTC_2800 7887935 6.33 81.8 µM 4.26E-8 RPP1 & pyrimidine depletion 4 1.24E-10
4 SGTC_1135 dihydrocapsaicin 5.87 536.7 nM 3.74E-7 6 2.16E-9
5 SGTC_1511 0906-3109 5.81 28.5 µM 4.97E-7 excess fatty acid 13 3.13E-9
6 SGTC_2084 5306078 5.81 60.6 µM 5.02E-7 3 3.18E-9
7 SGTC_65 0798-0905 5.71 35.0 µM 7.82E-7 calcium & mitochondrial duress 39 5.70E-9
8 SGTC_2450 5739737 5.70 12.9 µM 8.29E-7 5 6.16E-9
9 SGTC_3244 9134489 5.51 49.5 µM 1.83E-6 7 1.75E-8
10 SGTC_562 3772-2733 5.43 112.0 µM 2.66E-6 ERG2 42 2.87E-8
11 SGTC_637 1181-0519 5.39 7.3 µM 3.07E-6 fatty acid desaturase (OLE1) 59 3.47E-8
12 SGTC_863 0466-0191 5.19 129.0 µM 7.17E-6 cell wall 40 1.06E-7
13 SGTC_2376 9072922 5.17 81.3 µM 7.70E-6 7 1.17E-7
14 SGTC_2772 vinpocetine 5.08 57.1 µM 1.09E-5 9 1.86E-7
15 SGTC_1970 st070122 5.03 35.8 µM 1.34E-5 TSC3-RPN4 12 2.43E-7
16 SGTC_625 k213-0058 4.85 121.0 µM 2.67E-5 translation 62 6.05E-7
17 SGTC_1156 4092-0367 4.83 4.9 µM 2.89E-5 7 6.73E-7
18 SGTC_1090 efavirenz 4.81 20.7 µM 3.15E-5 9 7.54E-7
19 SGTC_549 1661-1316 4.79 519.0 µM 3.46E-5 7 8.54E-7
20 SGTC_2999 9069765 4.78 71.4 µM 3.56E-5 amide catabolism 11 8.87E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.30E-11 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.115 2.37E-11 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.115 2.52E-11 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.106 8.45E-10 YHR026W VMA16 hom Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
0.103 2.19E-9 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097 1.90E-8 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.094 5.51E-8 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.092 1.14E-7 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.091 1.35E-7 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.090 2.07E-7 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.090 2.12E-7 YGR106C VOA1 hom Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
0.088 3.60E-7 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.088 3.71E-7 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.087 4.41E-7 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.087 5.02E-7 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function