HIPHOP chemogenomics database

YDR264C / AKR1

Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR264C / AKR1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR264C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_121	0557-0495	7.87	61.3 µM	8.23E-12	calcium & mitochondrial duress	10	1.74E-15
2	SGTC_1636	st007707	7.18	68.9 µM	4.89E-10		14	3.58E-13
3	SGTC_2800	7887935	6.33	81.8 µM	4.26E-8	RPP1 & pyrimidine depletion	4	1.24E-10
4	SGTC_1135	dihydrocapsaicin	5.87	536.7 nM	3.74E-7		6	2.16E-9
5	SGTC_1511	0906-3109	5.81	28.5 µM	4.97E-7	excess fatty acid	13	3.13E-9
6	SGTC_2084	5306078	5.81	60.6 µM	5.02E-7		3	3.18E-9
7	SGTC_65	0798-0905	5.71	35.0 µM	7.82E-7	calcium & mitochondrial duress	39	5.70E-9
8	SGTC_2450	5739737	5.70	12.9 µM	8.29E-7		5	6.16E-9
9	SGTC_3244	9134489	5.51	49.5 µM	1.83E-6		7	1.75E-8
10	SGTC_562	3772-2733	5.43	112.0 µM	2.66E-6	ERG2	42	2.87E-8
11	SGTC_637	1181-0519	5.39	7.3 µM	3.07E-6	fatty acid desaturase (OLE1)	59	3.47E-8
12	SGTC_863	0466-0191	5.19	129.0 µM	7.17E-6	cell wall	40	1.06E-7
13	SGTC_2376	9072922	5.17	81.3 µM	7.70E-6		7	1.17E-7
14	SGTC_2772	vinpocetine	5.08	57.1 µM	1.09E-5		9	1.86E-7
15	SGTC_1970	st070122	5.03	35.8 µM	1.34E-5	TSC3-RPN4	12	2.43E-7
16	SGTC_625	k213-0058	4.85	121.0 µM	2.67E-5	translation	62	6.05E-7
17	SGTC_1156	4092-0367	4.83	4.9 µM	2.89E-5		7	6.73E-7
18	SGTC_1090	efavirenz	4.81	20.7 µM	3.15E-5		9	7.54E-7
19	SGTC_549	1661-1316	4.79	519.0 µM	3.46E-5		7	8.54E-7
20	SGTC_2999	9069765	4.78	71.4 µM	3.56E-5	amide catabolism	11	8.87E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.117	1.30E-11	YOR085W	OST3	hom	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.115	2.37E-11	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.115	2.52E-11	YBR229C	ROT2	hom	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.106	8.45E-10	YHR026W	VMA16	hom	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
0.103	2.19E-9	YNR040W_p	YNR040W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.097	1.90E-8	YBL082C	ALG3	hom	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.094	5.51E-8	YMR036C	MIH1	hom	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.092	1.14E-7	YBL022C	PIM1	hom	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.091	1.35E-7	YKL114C	APN1	hom	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.090	2.07E-7	YJL099W	CHS6	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.090	2.12E-7	YGR106C	VOA1	hom	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
0.088	3.60E-7	YMR152W	YIM1	hom	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.088	3.71E-7	YDL117W	CYK3	hom	SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.087	4.41E-7	YDR372C	VPS74	hom	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.087	5.02E-7	YDR293C	SSD1	hom	Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function