YDR265W / PEX10

Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR265W / PEX10

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:4.01|P-value:2.65E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.06|P-value:1.68E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.67|P-value:1.11E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.14|P-value:1.21E-16 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.17|P-value:6.93E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.44|P-value:3.77E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.67|P-value:1.26E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:4.47|P-value:3.26E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.90|P-value:4.19E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-4.42|P-value:4.25E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:3.14|P-value:7.70E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.51|P-value:2.73E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.26|P-value:8.89E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:4.75|P-value:8.43E-7 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.98|P-value:2.61E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:4.27|P-value:8.29E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:5.15|P-value:1.03E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.73|P-value:9.12E-7 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.53|P-value:1.83E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.70|P-value:9.47E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.23|P-value:1.01E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.14|P-value:7.83E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.63|P-value:1.26E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.53|P-value:2.49E-6 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.20|P-value:6.22E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.24|P-value:5.58E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-6.54|P-value:2.14E-11 ID:SGTC_1386|Compound:3228-0095|FD-Score:5.76|P-value:3.15E-9 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.26|P-value:8.59E-6 ID:SGTC_1703|Compound:st026983|FD-Score:-3.47|P-value:2.33E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.23|P-value:9.96E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.47|P-value:2.31E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.79|P-value:6.79E-5 ID:SGTC_1920|Compound:st075728|FD-Score:-3.41|P-value:3.00E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.33|P-value:3.97E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.09|P-value:9.27E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.93|P-value:3.66E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.43|P-value:2.72E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.26|P-value:5.13E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.50|P-value:2.07E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.32|P-value:4.02E-8 ID:SGTC_2258|Compound:7960471|FD-Score:-6.13|P-value:3.25E-10 ID:SGTC_2276|Compound:7947513|FD-Score:-3.81|P-value:6.27E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.83|P-value:5.63E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.63|P-value:6.86E-9 ID:SGTC_2460|Compound:5552655|FD-Score:-3.41|P-value:2.94E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.91|P-value:1.30E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.14|P-value:7.83E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-3.43|P-value:2.73E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.10|P-value:9.00E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.97|P-value:3.12E-5 ID:SGTC_3010|Compound:9080089|FD-Score:3.28|P-value:4.68E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.44|P-value:2.60E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.09|P-value:9.39E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.29|P-value:4.59E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-6.34|P-value:8.20E-11 ID:SGTC_39|Compound:0986-0283|FD-Score:4.01|P-value:2.65E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.06|P-value:1.68E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-3.67|P-value:1.11E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:8.14|P-value:1.21E-16 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.17|P-value:6.93E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.44|P-value:3.77E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.67|P-value:1.26E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:4.47|P-value:3.26E-6 ID:SGTC_805|Compound:3852-0218|FD-Score:3.90|P-value:4.19E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-4.42|P-value:4.25E-6 ID:SGTC_837|Compound:0091-0265|FD-Score:3.14|P-value:7.70E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.51|P-value:2.73E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.26|P-value:8.89E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:4.75|P-value:8.43E-7 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.98|P-value:2.61E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:4.27|P-value:8.29E-6 ID:SGTC_990|Compound:3985-0011|FD-Score:5.15|P-value:1.03E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.73|P-value:9.12E-7 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.53|P-value:1.83E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.70|P-value:9.47E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:4.23|P-value:1.01E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.14|P-value:7.83E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.63|P-value:1.26E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.53|P-value:2.49E-6 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.20|P-value:6.22E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.24|P-value:5.58E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-6.54|P-value:2.14E-11 ID:SGTC_1386|Compound:3228-0095|FD-Score:5.76|P-value:3.15E-9 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.26|P-value:8.59E-6 ID:SGTC_1703|Compound:st026983|FD-Score:-3.47|P-value:2.33E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.23|P-value:9.96E-6 ID:SGTC_1800|Compound:st050079|FD-Score:3.47|P-value:2.31E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.79|P-value:6.79E-5 ID:SGTC_1920|Compound:st075728|FD-Score:-3.41|P-value:3.00E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.33|P-value:3.97E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.09|P-value:9.27E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.93|P-value:3.66E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.43|P-value:2.72E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.26|P-value:5.13E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.50|P-value:2.07E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.32|P-value:4.02E-8 ID:SGTC_2258|Compound:7960471|FD-Score:-6.13|P-value:3.25E-10 ID:SGTC_2276|Compound:7947513|FD-Score:-3.81|P-value:6.27E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.83|P-value:5.63E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:5.63|P-value:6.86E-9 ID:SGTC_2460|Compound:5552655|FD-Score:-3.41|P-value:2.94E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:5.91|P-value:1.30E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.14|P-value:7.83E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-3.43|P-value:2.73E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.10|P-value:9.00E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.97|P-value:3.12E-5 ID:SGTC_3010|Compound:9080089|FD-Score:3.28|P-value:4.68E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.44|P-value:2.60E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.09|P-value:9.39E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.29|P-value:4.59E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-6.34|P-value:8.20E-11

Top fitness defect scores for YDR265W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_46 0329-0187a 8.14 2.2 µM 1.21E-16 15 2.06E-16
2 SGTC_2630 antimycin a 5.91 100.0 µM 1.30E-9 mitochondrial processes 13 1.73E-9
3 SGTC_1386 3228-0095 5.76 33.8 µM 3.15E-9 3 4.14E-9
4 SGTC_2407 paclitaxel 5.63 400.0 µM 6.86E-9 10 8.91E-9
5 SGTC_2249 haloperidol 5.32 116.4 µM 4.02E-8 ergosterol depletion effects on membrane 56 5.08E-8
6 SGTC_990 3985-0011 5.15 41.3 µM 1.03E-7 amide catabolism 6 1.28E-7
7 SGTC_902 1120-0002 4.75 2.1 µM 8.43E-7 azole & statin 30 1.02E-6
8 SGTC_1000 4048-0884 4.73 8.7 µM 9.12E-7 copper-dependent oxidative stress 19 1.10E-6
9 SGTC_457 grayanotoxin iii 4.67 135.0 µM 1.26E-6 36 1.52E-6
10 SGTC_1331 1472-0049 4.53 76.2 µM 2.49E-6 9 2.95E-6
11 SGTC_886 0866-0150 4.51 153.0 µM 2.73E-6 12 3.24E-6
12 SGTC_539 4859-0462 4.47 2.5 µM 3.26E-6 RNA pol III & RNase P/MRP 12 3.86E-6
13 SGTC_453 enantio-paf c16 4.44 10.0 µM 3.77E-6 111 4.45E-6
14 SGTC_978 1416-0512 4.27 87.4 µM 8.29E-6 redox potentiating 26 9.68E-6
15 SGTC_1565 sinapyl alcohol 4.26 95.1 µM 8.59E-6 23 1.00E-5
16 SGTC_895 0964-0006 4.26 13.7 µM 8.89E-6 7 1.04E-5
17 SGTC_1776 st049249 4.23 45.9 µM 9.96E-6 13 1.16E-5
18 SGTC_1186 1319-0216 4.23 26.0 µM 1.01E-5 14 1.18E-5
19 SGTC_39 0986-0283 4.01 58.4 µM 2.65E-5 calcium & mitochondrial duress 35 3.04E-5
20 SGTC_2760 etidronate 3.97 98.0 µM 3.12E-5 25 3.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.36E-12 YDL085C-A_p YDL085C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.109 2.89E-10 YOL083W ATG34 hom Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
0.104 1.50E-9 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.102 3.00E-9 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.097 1.54E-8 YGR061C ADE6 hom Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
0.097 1.71E-8 YDR278C_d YDR278C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.39E-8 YHR134W WSS1 hom Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.096 2.46E-8 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.096 2.85E-8 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.094 4.97E-8 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.094 5.55E-8 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.092 8.31E-8 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.090 1.65E-7 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.089 2.20E-7 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.088 3.61E-7 YJR018W_d YJR018W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data