YDR267C / CIA1

Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR267C / CIA1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.33|P-value:2.70E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.32|P-value:2.85E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.88|P-value:5.34E-10 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.20|P-value:4.66E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.15|P-value:8.34E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.19|P-value:4.61E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:5.50|P-value:5.90E-9 ID:SGTC_519|Compound:k048-0011|FD-Score:3.22|P-value:4.13E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.52|P-value:1.34E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:3.97|P-value:1.88E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.48|P-value:1.61E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.21|P-value:4.59E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.98|P-value:9.76E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.02|P-value:8.99E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.11|P-value:6.24E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.35|P-value:2.51E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.06|P-value:7.53E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.22|P-value:4.19E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.51|P-value:1.33E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.39|P-value:2.15E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.95|P-value:2.08E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-4.33|P-value:3.87E-6 ID:SGTC_2316|Compound:5844804|FD-Score:-3.85|P-value:3.48E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.37|P-value:2.49E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.95|P-value:2.11E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.02|P-value:8.43E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.12|P-value:6.28E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.50|P-value:1.40E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.31|P-value:2.92E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.28|P-value:4.41E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.15|P-value:9.10E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:7.67|P-value:8.82E-16 ID:SGTC_2655|Compound:perillic acid|FD-Score:5.40|P-value:1.06E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.09|P-value:6.57E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.30|P-value:3.05E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.31|P-value:2.90E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.15|P-value:5.42E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.62|P-value:8.45E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.50|P-value:1.50E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.60|P-value:1.01E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.20|P-value:4.44E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.33|P-value:2.70E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.32|P-value:2.85E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:5.88|P-value:5.34E-10 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.20|P-value:4.66E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.15|P-value:8.34E-6 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.19|P-value:4.61E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.46|P-value:1.66E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:5.50|P-value:5.90E-9 ID:SGTC_519|Compound:k048-0011|FD-Score:3.22|P-value:4.13E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.52|P-value:1.34E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:3.97|P-value:1.88E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.48|P-value:1.61E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.21|P-value:4.59E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:2.98|P-value:9.76E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.02|P-value:8.99E-4 ID:SGTC_1660|Compound:st012960|FD-Score:3.11|P-value:6.24E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.35|P-value:2.51E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.06|P-value:7.53E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.22|P-value:4.19E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.51|P-value:1.33E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.39|P-value:2.15E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.95|P-value:2.08E-5 ID:SGTC_2272|Compound:7805186|FD-Score:-4.33|P-value:3.87E-6 ID:SGTC_2316|Compound:5844804|FD-Score:-3.85|P-value:3.48E-5 ID:SGTC_2415|Compound:st077333|FD-Score:-3.37|P-value:2.49E-4 ID:SGTC_2451|Compound:5856223|FD-Score:3.95|P-value:2.11E-5 ID:SGTC_2456|Compound:5770359|FD-Score:3.02|P-value:8.43E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.12|P-value:6.28E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.50|P-value:1.40E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.31|P-value:2.92E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.28|P-value:4.41E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-4.15|P-value:9.10E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:7.67|P-value:8.82E-16 ID:SGTC_2655|Compound:perillic acid|FD-Score:5.40|P-value:1.06E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.09|P-value:6.57E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.30|P-value:3.05E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.08|P-value:6.94E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.31|P-value:2.90E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.15|P-value:5.42E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.62|P-value:8.45E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.50|P-value:1.50E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.60|P-value:1.01E-4 ID:SGTC_3324|Compound:9138759|FD-Score:3.20|P-value:4.44E-4

Top fitness defect scores for YDR267C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 7.67 70.0 µM 8.82E-16 redox potentiating 3 8.30E-15 1.59
2 SGTC_178 4092-0806 5.88 87.5 µM 5.34E-10 ergosterol depletion effects on membrane 12 2.04E-9 0.01
3 SGTC_518 1021-0119 5.50 62.6 µM 5.90E-9 ERG2 3 1.92E-8 0.84
4 SGTC_2655 perillic acid 5.40 100.0 µM 1.06E-8 1 3.32E-8 1.87
5 SGTC_704 1310-0270 4.52 142.0 µM 1.34E-6 1 3.03E-6 0.20
6 SGTC_2604 4'-hydroxychalcone 4.28 11.3 µM 4.41E-6 10 9.21E-6 0.02
7 SGTC_208 k072-0098 4.15 12.4 µM 8.34E-6 heme biosynthesis & mitochondrial translocase 17 1.67E-5 0.08
8 SGTC_808 0711-0032 3.97 135.0 µM 1.88E-5 9 3.56E-5 0.18
9 SGTC_2261 9010538 3.95 184.7 µM 2.08E-5 4 3.91E-5 0.01
10 SGTC_2451 5856223 3.95 45.7 µM 2.11E-5 11 3.97E-5 0.20
11 SGTC_3016 9080866 3.62 49.5 µM 8.45E-5 5 1.45E-4 0.26
12 SGTC_2009 4012297 3.51 12.1 µM 1.33E-4 cell wall signaling 12 2.22E-4 0.17
13 SGTC_2549 cedrol 3.50 20.9 µM 1.40E-4 18 2.32E-4 0.03
14 SGTC_1049 3226-0134 3.47 66.0 µM 1.55E-4 11 2.55E-4 0.07
15 SGTC_517 1365-0151 3.46 113.0 µM 1.66E-4 8 2.73E-4 0.00
16 SGTC_2205 7238770 3.39 200.0 µM 2.15E-4 3 3.48E-4 0.22
17 SGTC_1678 st019265 3.35 80.2 µM 2.51E-4 60S ribosome export 10 4.00E-4 0.03
18 SGTC_57 miconazole 3.33 162.5 nM 2.70E-4 ergosterol depletion effects on membrane 33 4.29E-4 0.01
19 SGTC_147 4466-0538 3.32 29.2 µM 2.85E-4 ergosterol biosynthesis 20 4.51E-4 0.13
20 SGTC_2992 9074591 3.31 71.4 µM 2.90E-4 7 4.59E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.03E-9 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.097 1.68E-8 YPR089W_p YPR089W_p hom Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
0.094 5.05E-8 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.093 7.08E-8 YOR119C RIO1 het Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
0.092 9.45E-8 YNL158W PGA1 het Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
0.092 9.88E-8 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.091 1.32E-7 YDR285W ZIP1 hom Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
0.090 2.01E-7 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.089 2.25E-7 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.087 4.66E-7 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.086 6.45E-7 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
0.083 1.32E-6 YKL163W PIR3 hom O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication
0.083 1.38E-6 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.081 2.82E-6 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.080 3.45E-6 YOR038C HIR2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p