YDR269C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR269C / YDR269C

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-3.90|P-value:3.61E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:21.70|P-value:2.81E-109 ID:SGTC_263|Compound:alizarin|FD-Score:7.39|P-value:2.09E-14 ID:SGTC_287|Compound:k060-0039|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.85|P-value:1.13E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:6.62|P-value:6.48E-12 ID:SGTC_382|Compound:3229-0966|FD-Score:3.93|P-value:2.86E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:4.84|P-value:3.60E-7 ID:SGTC_444|Compound:curcumin|FD-Score:4.17|P-value:9.89E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.66|P-value:9.05E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.87|P-value:3.72E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.73|P-value:6.80E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.63|P-value:9.97E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.16|P-value:6.05E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.14|P-value:7.38E-8 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.06|P-value:8.48E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.29|P-value:5.70E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.41|P-value:2.34E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.40|P-value:2.75E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.19|P-value:5.36E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.43|P-value:2.85E-6 ID:SGTC_1706|Compound:st031321|FD-Score:-3.09|P-value:8.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.63|P-value:9.88E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.88|P-value:3.60E-5 ID:SGTC_1834|Compound:st055981|FD-Score:4.43|P-value:2.85E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.09|P-value:8.53E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.16|P-value:6.55E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.94|P-value:2.21E-7 ID:SGTC_2046|Compound:4110841|FD-Score:4.77|P-value:5.27E-7 ID:SGTC_2071|Compound:5230951|FD-Score:-3.34|P-value:3.49E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.05|P-value:8.92E-4 ID:SGTC_2153|Compound:5569715|FD-Score:5.35|P-value:2.27E-8 ID:SGTC_2158|Compound:5657123|FD-Score:3.21|P-value:5.04E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.13|P-value:7.71E-8 ID:SGTC_2291|Compound:7917025|FD-Score:8.51|P-value:1.71E-18 ID:SGTC_2335|Compound:9018011|FD-Score:4.68|P-value:8.35E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.94|P-value:2.78E-5 ID:SGTC_2389|Compound:9091542|FD-Score:7.44|P-value:1.42E-14 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.46|P-value:1.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.10|P-value:6.14E-17 ID:SGTC_2586|Compound:curcumin|FD-Score:7.08|P-value:2.32E-13 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.16|P-value:1.03E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.24|P-value:4.97E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:10.50|P-value:4.41E-27 ID:SGTC_2864|Compound:9034755|FD-Score:-3.12|P-value:7.53E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.39|P-value:3.53E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.81|P-value:4.79E-5 ID:SGTC_2991|Compound:9074669|FD-Score:5.28|P-value:3.39E-8 ID:SGTC_3142|Compound:9086498|FD-Score:3.88|P-value:3.52E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.44|P-value:2.34E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.65|P-value:1.05E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.87|P-value:3.17E-7 ID:SGTC_3208|Compound:9114115|FD-Score:-4.52|P-value:2.12E-6 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.90|P-value:3.61E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:21.70|P-value:2.81E-109 ID:SGTC_263|Compound:alizarin|FD-Score:7.39|P-value:2.09E-14 ID:SGTC_287|Compound:k060-0039|FD-Score:3.23|P-value:4.60E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.85|P-value:1.13E-9 ID:SGTC_352|Compound:k048-0007|FD-Score:3.62|P-value:1.06E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:6.62|P-value:6.48E-12 ID:SGTC_382|Compound:3229-0966|FD-Score:3.93|P-value:2.86E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:4.84|P-value:3.60E-7 ID:SGTC_444|Compound:curcumin|FD-Score:4.17|P-value:9.89E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.66|P-value:9.05E-5 ID:SGTC_643|Compound:k048-0106|FD-Score:3.19|P-value:5.44E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.87|P-value:3.72E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:3.52|P-value:1.53E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.73|P-value:6.80E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.63|P-value:9.97E-5 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.31|P-value:3.53E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.16|P-value:6.05E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.14|P-value:7.38E-8 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.06|P-value:8.48E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:4.29|P-value:5.70E-6 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.41|P-value:2.34E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.40|P-value:2.75E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.19|P-value:5.36E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.48|P-value:1.79E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.43|P-value:2.85E-6 ID:SGTC_1706|Compound:st031321|FD-Score:-3.09|P-value:8.47E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.63|P-value:9.88E-5 ID:SGTC_1780|Compound:st038448|FD-Score:3.88|P-value:3.60E-5 ID:SGTC_1834|Compound:st055981|FD-Score:4.43|P-value:2.85E-6 ID:SGTC_1850|Compound:st056238|FD-Score:-3.09|P-value:8.53E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.16|P-value:6.55E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.94|P-value:2.21E-7 ID:SGTC_2046|Compound:4110841|FD-Score:4.77|P-value:5.27E-7 ID:SGTC_2071|Compound:5230951|FD-Score:-3.34|P-value:3.49E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.05|P-value:8.92E-4 ID:SGTC_2153|Compound:5569715|FD-Score:5.35|P-value:2.27E-8 ID:SGTC_2158|Compound:5657123|FD-Score:3.21|P-value:5.04E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.13|P-value:7.71E-8 ID:SGTC_2291|Compound:7917025|FD-Score:8.51|P-value:1.71E-18 ID:SGTC_2335|Compound:9018011|FD-Score:4.68|P-value:8.35E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.94|P-value:2.78E-5 ID:SGTC_2389|Compound:9091542|FD-Score:7.44|P-value:1.42E-14 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.46|P-value:1.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.10|P-value:6.14E-17 ID:SGTC_2586|Compound:curcumin|FD-Score:7.08|P-value:2.32E-13 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.16|P-value:1.03E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.24|P-value:4.97E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:10.50|P-value:4.41E-27 ID:SGTC_2864|Compound:9034755|FD-Score:-3.12|P-value:7.53E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.39|P-value:3.53E-6 ID:SGTC_2896|Compound:9052656|FD-Score:3.81|P-value:4.79E-5 ID:SGTC_2991|Compound:9074669|FD-Score:5.28|P-value:3.39E-8 ID:SGTC_3142|Compound:9086498|FD-Score:3.88|P-value:3.52E-5 ID:SGTC_3192|Compound:9110362|FD-Score:-3.44|P-value:2.34E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.65|P-value:1.05E-4 ID:SGTC_3203|Compound:9113543|FD-Score:4.87|P-value:3.17E-7 ID:SGTC_3208|Compound:9114115|FD-Score:-4.52|P-value:2.12E-6

Top fitness defect scores for YDR269C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 21.70 65.8 µM 2.81E-109 iron homeostasis 4 6.09E-105
2 SGTC_2675 theaflavin digallate 10.50 100.0 µM 4.41E-27 iron homeostasis 3 4.96E-26
3 SGTC_2291 7917025 8.51 104.3 µM 1.71E-18 iron homeostasis 14 8.71E-18
4 SGTC_2582 agaric acid 8.10 100.0 µM 6.14E-17 redox potentiating 101 2.70E-16
5 SGTC_2389 9091542 7.44 195.5 µM 1.42E-14 iron homeostasis 9 5.01E-14
6 SGTC_263 alizarin 7.39 107.9 µM 2.09E-14 iron homeostasis 12 7.27E-14
7 SGTC_2586 curcumin 7.08 80.0 µM 2.32E-13 iron homeostasis 6 7.30E-13
8 SGTC_374 0880-0231 6.62 82.3 µM 6.48E-12 iron homeostasis 3 1.78E-11
9 SGTC_339 3091-4833 5.85 71.4 µM 1.13E-9 iron homeostasis 3 2.53E-9
10 SGTC_2153 5569715 5.35 200.0 µM 2.27E-8 iron homeostasis 8 4.50E-8
11 SGTC_2991 9074669 5.28 71.4 µM 3.39E-8 azole & statin 26 6.61E-8
12 SGTC_1230 0170-0365 5.14 3.8 µM 7.38E-8 endomembrane recycling 36 1.39E-7
13 SGTC_2275 7947463 5.13 200.0 µM 7.71E-8 iron homeostasis 20 1.45E-7
14 SGTC_2021 4019055 4.94 173.0 µM 2.21E-7 endomembrane recycling 69 3.99E-7
15 SGTC_3203 9113543 4.87 49.5 µM 3.17E-7 12 5.65E-7
16 SGTC_431 k089-0097 4.84 107.0 µM 3.60E-7 iron homeostasis 16 6.38E-7
17 SGTC_2046 4110841 4.77 106.0 µM 5.27E-7 iron homeostasis 13 9.20E-7
18 SGTC_2335 9018011 4.68 154.2 µM 8.35E-7 19 1.43E-6
19 SGTC_1658 st012944 4.43 20.0 µM 2.85E-6 iron homeostasis 64 4.64E-6
20 SGTC_1834 st055981 4.43 52.8 µM 2.85E-6 RPP1 & pyrimidine depletion 22 4.65E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.605 0 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.594 1.25E-318 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.501 1.17E-212 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.499 5.49E-211 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.499 9.19E-211 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.492 9.92E-204 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.374 3.36E-112 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.315 9.81E-78 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.273 1.93E-58 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.243 3.23E-46 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.235 1.84E-43 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.204 9.12E-33 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.194 1.01E-29 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.193 1.61E-29 YOR256C TRE2 het Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
0.192 3.95E-29 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme