YDR270W / CCC2

Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR270W / CCC2

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.91|P-value:1.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.72|P-value:5.64E-8 ID:SGTC_75|Compound:0159-0059|FD-Score:3.79|P-value:2.90E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.60|P-value:4.01E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.88|P-value:2.14E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:24.80|P-value:1.28E-114 ID:SGTC_183|Compound:3914-0051|FD-Score:5.60|P-value:1.64E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:3.61|P-value:5.29E-4 ID:SGTC_263|Compound:alizarin|FD-Score:17.30|P-value:6.27E-57 ID:SGTC_264|Compound:promethazine|FD-Score:3.68|P-value:4.14E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.53|P-value:6.84E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.55|P-value:1.73E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.53|P-value:5.07E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.22|P-value:7.05E-9 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.61|P-value:3.92E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:6.98|P-value:9.14E-11 ID:SGTC_431|Compound:k089-0097|FD-Score:7.31|P-value:1.19E-11 ID:SGTC_444|Compound:curcumin|FD-Score:5.86|P-value:4.61E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.57|P-value:5.92E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.08|P-value:1.05E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.64|P-value:1.20E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.93|P-value:1.79E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.46|P-value:2.49E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.76|P-value:2.30E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.92|P-value:1.88E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.69|P-value:4.01E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.30|P-value:4.67E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.27|P-value:5.17E-9 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.74|P-value:3.44E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.10|P-value:9.77E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.22|P-value:7.09E-9 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.75|P-value:2.45E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.51|P-value:7.19E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.69|P-value:4.08E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.30|P-value:4.62E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.55|P-value:6.33E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.42|P-value:5.90E-12 ID:SGTC_1660|Compound:st012960|FD-Score:6.04|P-value:1.75E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:4.27|P-value:5.17E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.47|P-value:8.13E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.83|P-value:2.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.43|P-value:1.92E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.90|P-value:2.00E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-5.38|P-value:3.04E-7 ID:SGTC_1898|Compound:st060199|FD-Score:4.19|P-value:7.02E-5 ID:SGTC_1904|Compound:st060225|FD-Score:5.32|P-value:6.17E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.98|P-value:1.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.46|P-value:8.44E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.66|P-value:4.54E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.62|P-value:5.15E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.94|P-value:3.43E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.66|P-value:4.53E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.87|P-value:2.19E-4 ID:SGTC_2153|Compound:5569715|FD-Score:7.83|P-value:4.06E-13 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.34|P-value:3.88E-5 ID:SGTC_2275|Compound:7947463|FD-Score:12.50|P-value:9.60E-31 ID:SGTC_2286|Compound:7945697|FD-Score:8.17|P-value:3.97E-14 ID:SGTC_2291|Compound:7917025|FD-Score:28.00|P-value:1.33E-145 ID:SGTC_2292|Compound:7671323|FD-Score:3.74|P-value:3.47E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.47|P-value:8.17E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.54|P-value:1.79E-5 ID:SGTC_2389|Compound:9091542|FD-Score:6.41|P-value:2.52E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:9.65|P-value:5.32E-19 ID:SGTC_2516|Compound:gossypol|FD-Score:5.14|P-value:1.43E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:5.82E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.67|P-value:1.06E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:4.73|P-value:8.20E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.03|P-value:1.84E-8 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.83|P-value:2.51E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:7.28|P-value:1.49E-11 ID:SGTC_2695|Compound:st077686|FD-Score:-4.14|P-value:5.93E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.47|P-value:2.41E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.23|P-value:6.06E-5 ID:SGTC_2968|Compound:9090663|FD-Score:5.99|P-value:2.37E-8 ID:SGTC_2969|Compound:9091408|FD-Score:3.87|P-value:2.22E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.67|P-value:4.33E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.05|P-value:1.17E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.44|P-value:3.60E-7 ID:SGTC_11|Compound:0438-0307|FD-Score:3.91|P-value:1.89E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.72|P-value:5.64E-8 ID:SGTC_75|Compound:0159-0059|FD-Score:3.79|P-value:2.90E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.60|P-value:4.01E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.88|P-value:2.14E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:24.80|P-value:1.28E-114 ID:SGTC_183|Compound:3914-0051|FD-Score:5.60|P-value:1.64E-7 ID:SGTC_184|Compound:1494-0393|FD-Score:3.61|P-value:5.29E-4 ID:SGTC_263|Compound:alizarin|FD-Score:17.30|P-value:6.27E-57 ID:SGTC_264|Compound:promethazine|FD-Score:3.68|P-value:4.14E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.53|P-value:6.84E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.55|P-value:1.73E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.53|P-value:5.07E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.22|P-value:7.05E-9 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.61|P-value:3.92E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:6.98|P-value:9.14E-11 ID:SGTC_431|Compound:k089-0097|FD-Score:7.31|P-value:1.19E-11 ID:SGTC_444|Compound:curcumin|FD-Score:5.86|P-value:4.61E-8 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.57|P-value:5.92E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:4.08|P-value:1.05E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:4.64|P-value:1.20E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.93|P-value:1.79E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:4.46|P-value:2.49E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:-3.76|P-value:2.30E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.92|P-value:1.88E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.69|P-value:4.01E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.30|P-value:4.67E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.27|P-value:5.17E-9 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.74|P-value:3.44E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:4.10|P-value:9.77E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.22|P-value:7.09E-9 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.75|P-value:2.45E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.51|P-value:7.19E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.69|P-value:4.08E-4 ID:SGTC_1530|Compound:rhein|FD-Score:4.30|P-value:4.62E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.55|P-value:6.33E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.42|P-value:5.90E-12 ID:SGTC_1660|Compound:st012960|FD-Score:6.04|P-value:1.75E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:4.27|P-value:5.17E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.47|P-value:8.13E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.83|P-value:2.52E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.43|P-value:1.92E-5 ID:SGTC_1886|Compound:st057356|FD-Score:3.90|P-value:2.00E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-5.38|P-value:3.04E-7 ID:SGTC_1898|Compound:st060199|FD-Score:4.19|P-value:7.02E-5 ID:SGTC_1904|Compound:st060225|FD-Score:5.32|P-value:6.17E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.98|P-value:1.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.46|P-value:8.44E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.66|P-value:4.54E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.62|P-value:5.15E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.94|P-value:3.43E-6 ID:SGTC_2046|Compound:4110841|FD-Score:3.66|P-value:4.53E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.87|P-value:2.19E-4 ID:SGTC_2153|Compound:5569715|FD-Score:7.83|P-value:4.06E-13 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.34|P-value:3.88E-5 ID:SGTC_2275|Compound:7947463|FD-Score:12.50|P-value:9.60E-31 ID:SGTC_2286|Compound:7945697|FD-Score:8.17|P-value:3.97E-14 ID:SGTC_2291|Compound:7917025|FD-Score:28.00|P-value:1.33E-145 ID:SGTC_2292|Compound:7671323|FD-Score:3.74|P-value:3.47E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.47|P-value:8.17E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.54|P-value:1.79E-5 ID:SGTC_2389|Compound:9091542|FD-Score:6.41|P-value:2.52E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:9.65|P-value:5.32E-19 ID:SGTC_2516|Compound:gossypol|FD-Score:5.14|P-value:1.43E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:5.82E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.67|P-value:1.06E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:4.73|P-value:8.20E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.03|P-value:1.84E-8 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.83|P-value:2.51E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:7.28|P-value:1.49E-11 ID:SGTC_2695|Compound:st077686|FD-Score:-4.14|P-value:5.93E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.47|P-value:2.41E-5 ID:SGTC_2958|Compound:9077254|FD-Score:4.23|P-value:6.06E-5 ID:SGTC_2968|Compound:9090663|FD-Score:5.99|P-value:2.37E-8 ID:SGTC_2969|Compound:9091408|FD-Score:3.87|P-value:2.22E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.67|P-value:4.33E-4 ID:SGTC_3139|Compound:9095020|FD-Score:4.05|P-value:1.17E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.44|P-value:3.60E-7

Top fitness defect scores for YDR270W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2291 7917025 28.00 104.3 µM 1.33E-145 iron homeostasis 2 2.14E-172
2 SGTC_157 1348-1695 24.80 65.8 µM 1.28E-114 iron homeostasis 2 1.10E-135
3 SGTC_263 alizarin 17.30 107.9 µM 6.27E-57 iron homeostasis 1 2.60E-67
4 SGTC_2275 7947463 12.50 200.0 µM 9.60E-31 iron homeostasis 2 2.91E-36
5 SGTC_2418 pentamidine 9.65 31.7 µM 5.32E-19 mitochondrial processes 4 2.48E-22
6 SGTC_2286 7945697 8.17 125.0 µM 3.97E-14 6 1.50E-16
7 SGTC_2153 5569715 7.83 200.0 µM 4.06E-13 iron homeostasis 3 2.37E-15
8 SGTC_1658 st012944 7.42 20.0 µM 5.90E-12 iron homeostasis 13 5.68E-14
9 SGTC_431 k089-0097 7.31 107.0 µM 1.19E-11 iron homeostasis 5 1.30E-13
10 SGTC_2675 theaflavin digallate 7.28 100.0 µM 1.49E-11 iron homeostasis 6 1.71E-13
11 SGTC_374 0880-0231 6.98 82.3 µM 9.14E-11 iron homeostasis 2 1.47E-12
12 SGTC_2389 9091542 6.41 195.5 µM 2.52E-9 iron homeostasis 15 7.52E-11
13 SGTC_1110 3-hydroxy-3'-methoxyflavone 6.27 1.2 µM 5.17E-9 iron homeostasis 11 1.76E-10
14 SGTC_352 k048-0007 6.22 5.1 µM 7.05E-9 ERAD & cell cycle 32 2.55E-10
15 SGTC_1230 0170-0365 6.22 3.8 µM 7.09E-9 endomembrane recycling 17 2.57E-10
16 SGTC_1660 st012960 6.04 28.1 µM 1.75E-8 iron homeostasis 7 7.49E-10
17 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 6.03 70.0 µM 1.84E-8 redox potentiating 26 7.97E-10
18 SGTC_2968 9090663 5.99 33.4 µM 2.37E-8 6 1.08E-9
19 SGTC_444 curcumin 5.86 90.4 µM 4.61E-8 iron homeostasis 6 2.36E-9
20 SGTC_183 3914-0051 5.60 30.6 µM 1.64E-7 60S ribosome export 2 1.07E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.655 0 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.605 0 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.503 1.38E-214 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.480 2.15E-192 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.461 1.30E-176 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.440 1.86E-158 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.436 6.10E-156 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.306 1.59E-73 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.249 1.57E-48 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.246 1.82E-47 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.244 1.21E-46 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.233 1.94E-42 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.221 2.93E-38 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.205 3.01E-33 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.180 7.12E-26 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress