YDR271C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR271C / YDR271C

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-4.50|P-value:5.42E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.28|P-value:1.17E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.16|P-value:4.54E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.77|P-value:5.93E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.96|P-value:3.34E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:6.73|P-value:3.51E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.12|P-value:1.97E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:13.00|P-value:2.62E-29 ID:SGTC_227|Compound:fluconazole|FD-Score:6.01|P-value:1.18E-7 ID:SGTC_263|Compound:alizarin|FD-Score:6.09|P-value:8.06E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:4.11|P-value:2.03E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.65|P-value:8.33E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:5.50|P-value:1.12E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:3.70|P-value:7.34E-4 ID:SGTC_444|Compound:curcumin|FD-Score:10.60|P-value:3.12E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.80|P-value:2.49E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:4.21|P-value:1.45E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:12.90|P-value:6.19E-29 ID:SGTC_515|Compound:4092-1064|FD-Score:-5.82|P-value:2.85E-7 ID:SGTC_554|Compound:4483-2211|FD-Score:4.24|P-value:1.34E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.82|P-value:5.01E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.72|P-value:6.94E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.38|P-value:1.86E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:4.85|P-value:1.52E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:8.05|P-value:2.22E-12 ID:SGTC_809|Compound:3998-0021|FD-Score:6.04|P-value:1.03E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.73|P-value:6.64E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.25|P-value:1.28E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-4.47|P-value:6.02E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.24|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-4.12|P-value:1.98E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.45|P-value:6.48E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.00|P-value:8.60E-6 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.03|P-value:2.59E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.61|P-value:3.63E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.74|P-value:6.62E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.75|P-value:6.21E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.04|P-value:7.39E-6 ID:SGTC_1554|Compound:st069299|FD-Score:4.03|P-value:2.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.39|P-value:7.82E-5 ID:SGTC_1658|Compound:st012944|FD-Score:9.13|P-value:2.09E-15 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.79|P-value:5.56E-4 ID:SGTC_2046|Compound:4110841|FD-Score:5.52|P-value:1.02E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-3.71|P-value:7.20E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.35|P-value:9.23E-5 ID:SGTC_2153|Compound:5569715|FD-Score:10.20|P-value:1.14E-18 ID:SGTC_2275|Compound:7947463|FD-Score:6.03|P-value:1.08E-7 ID:SGTC_2291|Compound:7917025|FD-Score:8.73|P-value:3.05E-14 ID:SGTC_2389|Compound:9091542|FD-Score:10.60|P-value:3.64E-20 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.63|P-value:8.94E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.99|P-value:1.29E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.71|P-value:7.04E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.76|P-value:3.02E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:7.11|P-value:4.90E-10 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.37|P-value:1.92E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.43|P-value:1.51E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:6.06|P-value:9.34E-8 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.75|P-value:2.19E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:10.60|P-value:3.54E-20 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.60|P-value:9.73E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.36|P-value:8.97E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.71|P-value:2.53E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.08|P-value:2.28E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.14|P-value:1.84E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.37|P-value:8.57E-5 ID:SGTC_2845|Compound:9003024|FD-Score:5.68|P-value:5.06E-7 ID:SGTC_2867|Compound:9039098|FD-Score:4.45|P-value:6.36E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.61|P-value:9.48E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.75|P-value:6.36E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.49|P-value:5.80E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.30|P-value:1.08E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.88|P-value:1.35E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:-4.50|P-value:5.42E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.28|P-value:1.17E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-5.16|P-value:4.54E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.77|P-value:5.93E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.96|P-value:3.34E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:6.73|P-value:3.51E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-4.12|P-value:1.97E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:13.00|P-value:2.62E-29 ID:SGTC_227|Compound:fluconazole|FD-Score:6.01|P-value:1.18E-7 ID:SGTC_263|Compound:alizarin|FD-Score:6.09|P-value:8.06E-8 ID:SGTC_339|Compound:3091-4833|FD-Score:4.11|P-value:2.03E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.65|P-value:8.33E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:5.50|P-value:1.12E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:3.70|P-value:7.34E-4 ID:SGTC_444|Compound:curcumin|FD-Score:10.60|P-value:3.12E-20 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.80|P-value:2.49E-9 ID:SGTC_455|Compound:paf C-16|FD-Score:4.21|P-value:1.45E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:12.90|P-value:6.19E-29 ID:SGTC_515|Compound:4092-1064|FD-Score:-5.82|P-value:2.85E-7 ID:SGTC_554|Compound:4483-2211|FD-Score:4.24|P-value:1.34E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.82|P-value:5.01E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.72|P-value:6.94E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.38|P-value:1.86E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:4.85|P-value:1.52E-5 ID:SGTC_805|Compound:3852-0218|FD-Score:8.05|P-value:2.22E-12 ID:SGTC_809|Compound:3998-0021|FD-Score:6.04|P-value:1.03E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:3.73|P-value:6.64E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:4.25|P-value:1.28E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:-4.47|P-value:6.02E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-4.24|P-value:1.34E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-4.12|P-value:1.98E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.45|P-value:6.48E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.00|P-value:8.60E-6 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.03|P-value:2.59E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:4.61|P-value:3.63E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:-3.74|P-value:6.62E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.75|P-value:6.21E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.04|P-value:7.39E-6 ID:SGTC_1554|Compound:st069299|FD-Score:4.03|P-value:2.67E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.39|P-value:7.82E-5 ID:SGTC_1658|Compound:st012944|FD-Score:9.13|P-value:2.09E-15 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.79|P-value:5.56E-4 ID:SGTC_2046|Compound:4110841|FD-Score:5.52|P-value:1.02E-6 ID:SGTC_2057|Compound:5236571|FD-Score:-3.71|P-value:7.20E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.35|P-value:9.23E-5 ID:SGTC_2153|Compound:5569715|FD-Score:10.20|P-value:1.14E-18 ID:SGTC_2275|Compound:7947463|FD-Score:6.03|P-value:1.08E-7 ID:SGTC_2291|Compound:7917025|FD-Score:8.73|P-value:3.05E-14 ID:SGTC_2389|Compound:9091542|FD-Score:10.60|P-value:3.64E-20 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.63|P-value:8.94E-4 ID:SGTC_2482|Compound:5981709|FD-Score:5.99|P-value:1.29E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.71|P-value:7.04E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.76|P-value:3.02E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:7.11|P-value:4.90E-10 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.37|P-value:1.92E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.43|P-value:1.51E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:6.06|P-value:9.34E-8 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.75|P-value:2.19E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:10.60|P-value:3.54E-20 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.60|P-value:9.73E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.36|P-value:8.97E-5 ID:SGTC_2782|Compound:7736369|FD-Score:4.71|P-value:2.53E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.08|P-value:2.28E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.14|P-value:1.84E-4 ID:SGTC_2824|Compound:7998404|FD-Score:4.37|P-value:8.57E-5 ID:SGTC_2845|Compound:9003024|FD-Score:5.68|P-value:5.06E-7 ID:SGTC_2867|Compound:9039098|FD-Score:4.45|P-value:6.36E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.61|P-value:9.48E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-3.75|P-value:6.36E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.49|P-value:5.80E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.30|P-value:1.08E-4 ID:SGTC_3304|Compound:9125678|FD-Score:4.88|P-value:1.35E-5

Top fitness defect scores for YDR271C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 13.00 65.8 µM 2.62E-29 iron homeostasis 7 6.26E-39
2 SGTC_457 grayanotoxin iii 12.90 135.0 µM 6.19E-29 3 2.00E-38
3 SGTC_444 curcumin 10.60 90.4 µM 3.12E-20 iron homeostasis 1 1.10E-26
4 SGTC_2675 theaflavin digallate 10.60 100.0 µM 3.54E-20 iron homeostasis 2 1.30E-26
5 SGTC_2389 9091542 10.60 195.5 µM 3.64E-20 iron homeostasis 2 1.35E-26
6 SGTC_2153 5569715 10.20 200.0 µM 1.14E-18 iron homeostasis 1 1.41E-24
7 SGTC_1658 st012944 9.13 20.0 µM 2.09E-15 iron homeostasis 5 3.53E-20
8 SGTC_2291 7917025 8.73 104.3 µM 3.05E-14 iron homeostasis 13 1.30E-18
9 SGTC_805 3852-0218 8.05 479.0 µM 2.22E-12 ERAD & cell cycle 12 4.16E-16
10 SGTC_2586 curcumin 7.11 80.0 µM 4.90E-10 iron homeostasis 5 5.92E-13
11 SGTC_453 enantio-paf c16 6.80 10.0 µM 2.49E-9 28 5.27E-12
12 SGTC_2582 agaric acid 6.76 100.0 µM 3.02E-9 redox potentiating 137 6.82E-12
13 SGTC_139 0099-0334 6.73 718.6 µM 3.51E-9 3 8.33E-12
14 SGTC_263 alizarin 6.09 107.9 µM 8.06E-8 iron homeostasis 26 5.59E-10
15 SGTC_2640 pentamidine 6.06 10.4 µM 9.34E-8 mitochondrial processes 6 6.81E-10
16 SGTC_809 3998-0021 6.04 90.0 µM 1.03E-7 RNA processing & uracil transport 2 7.82E-10
17 SGTC_2275 7947463 6.03 200.0 µM 1.08E-7 iron homeostasis 11 8.31E-10
18 SGTC_227 fluconazole 6.01 33.5 µM 1.18E-7 azole & statin 41 9.32E-10
19 SGTC_2482 5981709 5.99 142.7 µM 1.29E-7 PDR1 9 1.05E-9
20 SGTC_2845 9003024 5.68 43.0 µM 5.06E-7 amide catabolism 18 6.56E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.499 9.19E-211 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.461 1.30E-176 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.411 1.32E-136 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.392 1.76E-123 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.383 1.31E-117 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.355 2.13E-100 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.251 2.96E-49 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.246 2.22E-47 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.217 3.97E-37 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.206 1.19E-33 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.192 3.04E-29 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.186 1.23E-27 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.185 3.39E-27 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.184 5.23E-27 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.173 6.91E-24 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6