YDR274C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR274C / YDR274C

Click on Significant Values for Screen Details ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.03|P-value:3.43E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.91|P-value:6.65E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-4.54|P-value:2.13E-7 ID:SGTC_317|Compound:4495-0002|FD-Score:3.03|P-value:3.71E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:4.27|P-value:9.48E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.01|P-value:4.01E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.09|P-value:2.62E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.89|P-value:6.48E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.92|P-value:5.60E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.02|P-value:3.81E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.10|P-value:2.72E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.96|P-value:4.88E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:2.79|P-value:9.42E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.03|P-value:3.53E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:4.45|P-value:3.44E-7 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.54|P-value:3.93E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.95|P-value:4.95E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:2.99|P-value:4.30E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.09|P-value:2.82E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.16|P-value:2.12E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.09|P-value:2.80E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.99|P-value:4.23E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.98|P-value:4.61E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:-5.00|P-value:1.23E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.02|P-value:9.38E-12 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.38|P-value:8.10E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.19|P-value:1.86E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:2.96|P-value:4.74E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:2.89|P-value:6.49E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.78|P-value:9.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.71|P-value:1.78E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.44|P-value:6.39E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.76|P-value:1.38E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.61|P-value:2.88E-5 ID:SGTC_1772|Compound:st048439|FD-Score:-3.03|P-value:3.68E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.10|P-value:2.69E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.28|P-value:1.26E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.65|P-value:2.35E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-3.69|P-value:1.99E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.39|P-value:7.97E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.84|P-value:9.34E-6 ID:SGTC_2397|Compound:5161689|FD-Score:2.81|P-value:8.59E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.63|P-value:2.62E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.07|P-value:2.81E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-2.95|P-value:5.10E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.06|P-value:3.26E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.89|P-value:7.13E-6 ID:SGTC_3009|Compound:9080819|FD-Score:2.91|P-value:5.82E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.04|P-value:3.51E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.03|P-value:3.43E-6 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.91|P-value:6.65E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-4.54|P-value:2.13E-7 ID:SGTC_317|Compound:4495-0002|FD-Score:3.03|P-value:3.71E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:4.27|P-value:9.48E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.01|P-value:4.01E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:4.09|P-value:2.62E-6 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.89|P-value:6.48E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:2.92|P-value:5.60E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.02|P-value:3.81E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.10|P-value:2.72E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:2.96|P-value:4.88E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:2.79|P-value:9.42E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.03|P-value:3.53E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:4.45|P-value:3.44E-7 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.54|P-value:3.93E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:2.95|P-value:4.95E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:2.99|P-value:4.30E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.09|P-value:2.82E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.16|P-value:2.12E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.09|P-value:2.80E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.99|P-value:4.23E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.98|P-value:4.61E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:-5.00|P-value:1.23E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:6.02|P-value:9.38E-12 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.38|P-value:8.10E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.19|P-value:1.86E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:2.96|P-value:4.74E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:2.89|P-value:6.49E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.78|P-value:9.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.71|P-value:1.78E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.44|P-value:6.39E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:3.76|P-value:1.38E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.61|P-value:2.88E-5 ID:SGTC_1772|Compound:st048439|FD-Score:-3.03|P-value:3.68E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.10|P-value:2.69E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-3.28|P-value:1.26E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.65|P-value:2.35E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-3.69|P-value:1.99E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.39|P-value:7.97E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.84|P-value:9.34E-6 ID:SGTC_2397|Compound:5161689|FD-Score:2.81|P-value:8.59E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.63|P-value:2.62E-5 ID:SGTC_2806|Compound:7952793|FD-Score:-4.07|P-value:2.81E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-2.95|P-value:5.10E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.06|P-value:3.26E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.89|P-value:7.13E-6 ID:SGTC_3009|Compound:9080819|FD-Score:2.91|P-value:5.82E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.04|P-value:3.51E-4

Top fitness defect scores for YDR274C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1230 0170-0365 6.02 3.8 µM 9.38E-12 endomembrane recycling 20 8.54E-10
2 SGTC_972 1319-0219 4.45 195.0 µM 3.44E-7 14 4.23E-6
3 SGTC_374 0880-0231 4.27 82.3 µM 9.48E-7 iron homeostasis 18 9.63E-6
4 SGTC_388 3',4'-dichloroisocoumarin 4.09 16.7 µM 2.62E-6 11 2.20E-5
5 SGTC_875 0709-0210 4.03 25.7 µM 3.53E-6 fatty acid desaturase (OLE1) 30 2.80E-5
6 SGTC_1207 2099-0101 3.99 141.0 µM 4.23E-6 18 3.25E-5
7 SGTC_2999 9069765 3.89 71.4 µM 7.13E-6 amide catabolism 27 4.96E-5
8 SGTC_2347 9049783 3.84 174.8 µM 9.34E-6 35 6.17E-5
9 SGTC_1552 6-methylflavone 3.76 10.6 µM 1.38E-5 superoxide 20 8.48E-5
10 SGTC_2645 abamectin 3.63 100.0 µM 2.62E-5 heme requiring 42 1.43E-4
11 SGTC_1739 st037196 3.61 92.5 µM 2.88E-5 36 1.54E-4
12 SGTC_1525 8-methoxypsoralen 3.44 92.5 µM 6.39E-5 DNA damage response 50 2.95E-4
13 SGTC_2339 9000433 3.39 200.0 µM 7.97E-5 55 3.54E-4
14 SGTC_1267 0828-0272 3.38 9.5 µM 8.10E-5 38 3.58E-4
15 SGTC_1276 0871-0068 3.19 94.2 µM 1.86E-4 43 7.04E-4
16 SGTC_1059 3448-6867 3.16 171.0 µM 2.12E-4 35 7.86E-4
17 SGTC_1784 st039334 3.10 36.3 µM 2.69E-4 52 9.54E-4
18 SGTC_456 gingerol 3.10 170.0 µM 2.72E-4 53 9.63E-4
19 SGTC_1192 1488-0095 3.09 21.4 µM 2.80E-4 47 9.85E-4
20 SGTC_1056 3448-1962 3.09 115.0 µM 2.82E-4 amide catabolism 47 9.89E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 1.11E-28 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.158 4.81E-20 YCR073C SSK22 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
0.142 1.38E-16 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.141 2.21E-16 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.141 2.63E-16 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.137 1.73E-15 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.131 3.07E-14 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.129 7.42E-14 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.127 1.46E-13 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.125 4.60E-13 YDR009W GAL3 hom Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication
0.123 8.84E-13 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.122 1.52E-12 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.118 7.62E-12 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.117 1.31E-11 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.112 1.03E-10 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor