YDR275W / BSC2

Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR275W / BSC2

Click on Significant Values for Screen Details ID:SGTC_115|Compound:0527-0192|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.66|P-value:9.15E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.76|P-value:5.48E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:3.45|P-value:2.12E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.86|P-value:3.09E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:3.07|P-value:8.65E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.21|P-value:4.01E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.24|P-value:4.67E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.83|P-value:4.57E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.79|P-value:5.27E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.72|P-value:7.04E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.76|P-value:6.01E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.19|P-value:5.56E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.21|P-value:5.25E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.07|P-value:6.70E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.27|P-value:4.12E-4 ID:SGTC_1708|Compound:st033234|FD-Score:-3.07|P-value:6.70E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.03|P-value:7.88E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.06|P-value:7.11E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.35|P-value:2.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.86|P-value:3.85E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.33|P-value:2.54E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.09|P-value:7.94E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.29|P-value:5.60E-6 ID:SGTC_2273|Compound:7815444|FD-Score:-2.99|P-value:8.89E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.10|P-value:7.79E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.26|P-value:4.29E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.26|P-value:3.43E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.43|P-value:2.27E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.13|P-value:5.46E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.06|P-value:9.04E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-4.36|P-value:2.92E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.45|P-value:2.53E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.88|P-value:2.66E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.66|P-value:9.15E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.76|P-value:5.48E-7 ID:SGTC_169|Compound:k015-0017|FD-Score:3.45|P-value:2.12E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:4.86|P-value:3.09E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:3.07|P-value:8.65E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.21|P-value:4.01E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.24|P-value:4.67E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.83|P-value:4.57E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.56|P-value:1.38E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.79|P-value:5.27E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:3.72|P-value:7.04E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.76|P-value:6.01E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.19|P-value:5.56E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.21|P-value:5.25E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.07|P-value:6.70E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.27|P-value:4.12E-4 ID:SGTC_1708|Compound:st033234|FD-Score:-3.07|P-value:6.70E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.22|P-value:5.08E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.03|P-value:7.88E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:-3.06|P-value:7.11E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-3.35|P-value:2.37E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.86|P-value:3.85E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.33|P-value:2.54E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.09|P-value:7.94E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.29|P-value:5.60E-6 ID:SGTC_2273|Compound:7815444|FD-Score:-2.99|P-value:8.89E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.10|P-value:7.79E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.26|P-value:4.29E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.26|P-value:3.43E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.43|P-value:2.27E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.13|P-value:5.46E-4 ID:SGTC_3040|Compound:9091894|FD-Score:3.06|P-value:9.04E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-4.36|P-value:2.92E-6 ID:SGTC_3205|Compound:9113483|FD-Score:4.45|P-value:2.53E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-3.88|P-value:2.66E-5

Top fitness defect scores for YDR275W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_196 k015-0023 4.86 18.1 µM 3.09E-7 PDR1 10 5.74E-7
2 SGTC_159 3970-0959 4.76 50.0 µM 5.48E-7 47 9.85E-7
3 SGTC_3205 9113483 4.45 49.5 µM 2.53E-6 16 4.20E-6
4 SGTC_2102 5377816 4.29 72.8 µM 5.60E-6 16 8.91E-6
5 SGTC_1926 methyl fluorone black 3.86 53.6 µM 3.85E-5 DNA intercalators 65 5.56E-5
6 SGTC_561 1550-0330 3.83 72.9 µM 4.57E-5 9 6.54E-5
7 SGTC_939 1165-0479 3.79 45.3 µM 5.27E-5 32 7.49E-5
8 SGTC_1020 4335-0961 3.76 93.3 µM 6.01E-5 21 8.47E-5
9 SGTC_959 1222-0044 3.72 107.0 µM 7.04E-5 26 9.85E-5
10 SGTC_145 3737-0113 3.66 38.4 µM 9.15E-5 DNA intercalators 90 1.26E-4
11 SGTC_756 0508-1999 3.56 28.3 µM 1.38E-4 RPP1 & pyrimidine depletion 42 1.87E-4
12 SGTC_169 k015-0017 3.45 16.0 µM 2.12E-4 33 2.81E-4
13 SGTC_2777 climbazole 3.43 1.5 µM 2.27E-4 iron homeostasis 74 3.00E-4
14 SGTC_115 0527-0192 3.28 112.0 µM 3.97E-4 114 5.10E-4
15 SGTC_1534 6-azauridine 3.27 81.6 µM 4.12E-4 RNA pol III & RNase P/MRP 52 5.29E-4
16 SGTC_2409 alverine citrate 3.26 64.0 µM 4.29E-4 80 5.50E-4
17 SGTC_485 niflumic acid 3.24 177.0 µM 4.67E-4 25 5.96E-4
18 SGTC_1782 st039423 3.22 80.6 µM 5.08E-4 54 6.45E-4
19 SGTC_1263 0774-1208 3.21 64.8 µM 5.25E-4 89 6.65E-4
20 SGTC_1026 k007-1105 3.19 30.6 µM 5.56E-4 ERAD & cell cycle 140 7.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 4.90E-22 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.142 1.58E-16 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.126 2.10E-13 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.125 4.27E-13 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.121 2.29E-12 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.117 8.56E-12 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.113 5.93E-11 YDR005C MAF1 hom Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
0.111 1.13E-10 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.110 1.46E-10 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 5.03E-10 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.107 6.26E-10 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.103 1.85E-9 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.102 3.04E-9 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.098 1.10E-8 YDR022C ATG31 hom Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
0.098 1.16E-8 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p