YDR276C / PMP3

Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR276C / PMP3

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.95|P-value:3.77E-7 ID:SGTC_20|Compound:0481-0013|FD-Score:4.12|P-value:1.94E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.08|P-value:1.91E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.46|P-value:4.16E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.34|P-value:4.58E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:3.16|P-value:8.29E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.61|P-value:2.09E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.22|P-value:6.84E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.16|P-value:8.52E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.83|P-value:7.17E-7 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.20|P-value:7.25E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.17|P-value:8.05E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.28|P-value:9.61E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:4.02|P-value:3.02E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:5.35|P-value:4.33E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:5.33|P-value:5.01E-8 ID:SGTC_969|Compound:1313-0238|FD-Score:3.15|P-value:8.72E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.21|P-value:5.24E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.74|P-value:9.83E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.54|P-value:2.08E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.39|P-value:3.72E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.10|P-value:2.18E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.15|P-value:8.70E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.83|P-value:6.61E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.18|P-value:5.87E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.11|P-value:9.89E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.73|P-value:1.00E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.35|P-value:9.01E-14 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.18|P-value:7.94E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.73|P-value:1.18E-6 ID:SGTC_1635|Compound:st007035|FD-Score:7.99|P-value:5.68E-16 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.33|P-value:3.40E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.15|P-value:8.67E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.69|P-value:1.02E-11 ID:SGTC_1872|Compound:amphotericin b|FD-Score:11.80|P-value:6.17E-33 ID:SGTC_1884|Compound:5633444|FD-Score:8.53|P-value:5.89E-18 ID:SGTC_1917|Compound:st066507|FD-Score:3.45|P-value:2.98E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.86|P-value:5.99E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.96|P-value:3.87E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.07|P-value:2.45E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.32|P-value:4.85E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.66|P-value:1.66E-6 ID:SGTC_2481|Compound:5478948|FD-Score:-3.18|P-value:5.88E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.42|P-value:2.47E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.12|P-value:4.57E-10 ID:SGTC_2526|Compound:patulin|FD-Score:3.27|P-value:5.76E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.04|P-value:2.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.27|P-value:6.89E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-5.20|P-value:6.51E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.59|P-value:2.28E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-3.50|P-value:1.76E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:8.23|P-value:7.97E-17 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.26|P-value:1.07E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.07|P-value:2.41E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.55|P-value:1.49E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.73|P-value:1.03E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.20|P-value:7.40E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.25|P-value:6.08E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.46|P-value:2.08E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.95|P-value:3.77E-7 ID:SGTC_20|Compound:0481-0013|FD-Score:4.12|P-value:1.94E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:5.08|P-value:1.91E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.46|P-value:4.16E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.31|P-value:4.94E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:5.34|P-value:4.58E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:3.16|P-value:8.29E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.61|P-value:2.09E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.22|P-value:6.84E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.16|P-value:8.52E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.83|P-value:7.17E-7 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.20|P-value:7.25E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.17|P-value:8.05E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.28|P-value:9.61E-6 ID:SGTC_507|Compound:nimesulide|FD-Score:4.02|P-value:3.02E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:5.35|P-value:4.33E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:5.33|P-value:5.01E-8 ID:SGTC_969|Compound:1313-0238|FD-Score:3.15|P-value:8.72E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.21|P-value:5.24E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.23|P-value:1.20E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.74|P-value:9.83E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.45|P-value:3.01E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.54|P-value:2.08E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.39|P-value:3.72E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.10|P-value:2.18E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.15|P-value:8.70E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.83|P-value:6.61E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:-3.18|P-value:5.87E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.11|P-value:9.89E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.73|P-value:1.00E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.35|P-value:9.01E-14 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.18|P-value:7.94E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.73|P-value:1.18E-6 ID:SGTC_1635|Compound:st007035|FD-Score:7.99|P-value:5.68E-16 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.33|P-value:3.40E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.15|P-value:8.67E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.69|P-value:1.02E-11 ID:SGTC_1872|Compound:amphotericin b|FD-Score:11.80|P-value:6.17E-33 ID:SGTC_1884|Compound:5633444|FD-Score:8.53|P-value:5.89E-18 ID:SGTC_1917|Compound:st066507|FD-Score:3.45|P-value:2.98E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.86|P-value:5.99E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.96|P-value:3.87E-5 ID:SGTC_2049|Compound:5262831|FD-Score:4.07|P-value:2.45E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.32|P-value:4.85E-4 ID:SGTC_2399|Compound:5884133|FD-Score:4.66|P-value:1.66E-6 ID:SGTC_2481|Compound:5478948|FD-Score:-3.18|P-value:5.88E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.42|P-value:2.47E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.12|P-value:4.57E-10 ID:SGTC_2526|Compound:patulin|FD-Score:3.27|P-value:5.76E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.04|P-value:2.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.27|P-value:6.89E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:-5.20|P-value:6.51E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:4.59|P-value:2.28E-6 ID:SGTC_2698|Compound:st077697|FD-Score:-3.50|P-value:1.76E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:8.23|P-value:7.97E-17 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.26|P-value:1.07E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.07|P-value:2.41E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.55|P-value:1.49E-4 ID:SGTC_2964|Compound:9083345|FD-Score:3.73|P-value:1.03E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.20|P-value:7.40E-4 ID:SGTC_3284|Compound:9108171|FD-Score:3.25|P-value:6.08E-4

Top fitness defect scores for YDR276C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1872 amphotericin b 11.80 148.0 nM 6.17E-33 RNA pol III & RNase P/MRP 2 1.11E-32
2 SGTC_1884 5633444 8.53 25.0 µM 5.89E-18 redox potentiating 17 7.23E-18
3 SGTC_2737 bleomycin 8.23 30.5 nM 7.97E-17 Golgi 17 9.53E-17
4 SGTC_1635 st007035 7.99 42.4 µM 5.68E-16 97 6.66E-16
5 SGTC_1495 4469-0029 7.35 237.0 µM 9.01E-14 30 1.01E-13
6 SGTC_1687 st020778 6.69 55.4 µM 1.02E-11 91 1.09E-11
7 SGTC_2500 5-alpha-androstan-3,17-dione 6.12 61.4 µM 4.57E-10 10 4.72E-10
8 SGTC_724 3910-0327 5.35 137.0 µM 4.33E-8 ERG2 4 4.31E-8
9 SGTC_129 0088-0017 5.34 176.6 µM 4.58E-8 37 4.56E-8
10 SGTC_946 3434-1334 5.33 87.4 µM 5.01E-8 9 4.98E-8
11 SGTC_43 0570-0105 5.08 72.5 µM 1.91E-7 ERG2 51 1.88E-7
12 SGTC_14 0354-0009 4.95 295.0 µM 3.77E-7 11 3.69E-7
13 SGTC_214 4373-3496 4.83 70.0 µM 7.17E-7 34 6.99E-7
14 SGTC_1597 7-benzyloxygramine 4.73 47.5 µM 1.18E-6 calcium & mitochondrial duress 75 1.15E-6
15 SGTC_2399 5884133 4.66 200.0 µM 1.66E-6 cell wall signaling 48 1.61E-6
16 SGTC_168 3970-0862 4.61 530.5 µM 2.09E-6 86 2.02E-6
17 SGTC_2619 obliquin 4.59 87.9 µM 2.28E-6 cell wall 112 2.20E-6
18 SGTC_70 0141-0289 4.46 43.3 µM 4.16E-6 mitochondrial stress 140 4.02E-6
19 SGTC_505 gw-5074 4.28 63.9 µM 9.61E-6 47 9.23E-6
20 SGTC_2752 diclazuril 4.26 33.1 µM 1.07E-5 102 1.03E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.212 3.32E-35 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.191 1.15E-28 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.187 1.10E-27 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.177 7.34E-25 YER048C CAJ1 hom Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
0.175 3.15E-24 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.169 9.74E-23 YLR370C ARC18 hom Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.162 5.75E-21 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.157 5.97E-20 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.154 3.20E-19 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.154 4.08E-19 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.153 5.22E-19 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.152 1.24E-18 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.150 2.12E-18 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.150 2.41E-18 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.149 4.95E-18 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P