YDR281C / PHM6

Protein of unknown function, expression is regulated by phosphate levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR281C / PHM6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.45|P-value:8.06E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.58|P-value:5.50E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.64|P-value:4.50E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.52|P-value:6.50E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.77|P-value:2.89E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.60|P-value:1.60E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:9.19|P-value:2.41E-17 ID:SGTC_660|Compound:4031-1742|FD-Score:3.61|P-value:4.88E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.64|P-value:4.43E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.88|P-value:1.97E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.42|P-value:2.77E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.31|P-value:4.23E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.83|P-value:2.36E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.12|P-value:1.50E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.38|P-value:3.18E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.95|P-value:1.53E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.65|P-value:1.09E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-4.08|P-value:9.87E-5 ID:SGTC_1650|Compound:st011916|FD-Score:6.11|P-value:1.20E-8 ID:SGTC_1670|Compound:st016595|FD-Score:3.69|P-value:3.81E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.68|P-value:3.88E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.27|P-value:4.77E-5 ID:SGTC_1781|Compound:st038725|FD-Score:-6.50|P-value:1.49E-9 ID:SGTC_1889|Compound:st059080|FD-Score:4.02|P-value:1.22E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-5.25|P-value:8.06E-7 ID:SGTC_1934|Compound:st074720|FD-Score:-3.65|P-value:4.25E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.41|P-value:9.36E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.36|P-value:3.43E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-4.73|P-value:7.80E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.74|P-value:3.20E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.48|P-value:7.52E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-4.12|P-value:8.29E-5 ID:SGTC_2134|Compound:5324836|FD-Score:3.83|P-value:2.34E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.51|P-value:6.75E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.52|P-value:6.59E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.02|P-value:1.19E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.41|P-value:9.15E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.33|P-value:3.92E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.97|P-value:1.47E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.52|P-value:6.63E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.50|P-value:6.95E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.41|P-value:9.21E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.96|P-value:2.97E-6 ID:SGTC_2810|Compound:7959871|FD-Score:9.27|P-value:1.35E-17 ID:SGTC_2830|Compound:7992007|FD-Score:3.66|P-value:4.14E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.41|P-value:9.40E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.70|P-value:8.72E-6 ID:SGTC_2881|Compound:9058953|FD-Score:-3.40|P-value:9.59E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.67|P-value:4.09E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.73|P-value:3.29E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.82|P-value:2.42E-4 ID:SGTC_3296|Compound:9122258|FD-Score:5.45|P-value:3.26E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.45|P-value:8.06E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.58|P-value:5.50E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.64|P-value:4.50E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.52|P-value:6.50E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.77|P-value:2.89E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-5.60|P-value:1.60E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:9.19|P-value:2.41E-17 ID:SGTC_660|Compound:4031-1742|FD-Score:3.61|P-value:4.88E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.64|P-value:4.43E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.88|P-value:1.97E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.42|P-value:2.77E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:4.31|P-value:4.23E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.83|P-value:2.36E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.12|P-value:1.50E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.38|P-value:3.18E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.95|P-value:1.53E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.65|P-value:1.09E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-4.08|P-value:9.87E-5 ID:SGTC_1650|Compound:st011916|FD-Score:6.11|P-value:1.20E-8 ID:SGTC_1670|Compound:st016595|FD-Score:3.69|P-value:3.81E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.68|P-value:3.88E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-4.27|P-value:4.77E-5 ID:SGTC_1781|Compound:st038725|FD-Score:-6.50|P-value:1.49E-9 ID:SGTC_1889|Compound:st059080|FD-Score:4.02|P-value:1.22E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-5.25|P-value:8.06E-7 ID:SGTC_1934|Compound:st074720|FD-Score:-3.65|P-value:4.25E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.41|P-value:9.36E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.36|P-value:3.43E-5 ID:SGTC_2057|Compound:5236571|FD-Score:-4.73|P-value:7.80E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.74|P-value:3.20E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.48|P-value:7.52E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-4.12|P-value:8.29E-5 ID:SGTC_2134|Compound:5324836|FD-Score:3.83|P-value:2.34E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.51|P-value:6.75E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.52|P-value:6.59E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.02|P-value:1.19E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.41|P-value:9.15E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:4.33|P-value:3.92E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.97|P-value:1.47E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.52|P-value:6.63E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.50|P-value:6.95E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:-3.41|P-value:9.21E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.96|P-value:2.97E-6 ID:SGTC_2810|Compound:7959871|FD-Score:9.27|P-value:1.35E-17 ID:SGTC_2830|Compound:7992007|FD-Score:3.66|P-value:4.14E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.41|P-value:9.40E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.70|P-value:8.72E-6 ID:SGTC_2881|Compound:9058953|FD-Score:-3.40|P-value:9.59E-4 ID:SGTC_2925|Compound:9010536|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_2972|Compound:9093619|FD-Score:3.67|P-value:4.09E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.73|P-value:3.29E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.82|P-value:2.42E-4 ID:SGTC_3296|Compound:9122258|FD-Score:5.45|P-value:3.26E-7

Top fitness defect scores for YDR281C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2810 7959871 9.27 45.5 µM 1.35E-17 copper-dependent oxidative stress 4 9.71E-21
2 SGTC_625 k213-0058 9.19 121.0 µM 2.41E-17 translation 6 1.95E-20
3 SGTC_1650 st011916 6.11 45.8 µM 1.20E-8 1 4.89E-10
4 SGTC_3296 9122258 5.45 64.0 µM 3.26E-7 redox potentiating 10 2.52E-8
5 SGTC_1353 1498-1206 5.12 8.1 µM 1.50E-6 mitochondrial response to ROS 28 1.56E-7
6 SGTC_1635 st007035 4.65 42.4 µM 1.09E-5 179 1.65E-6
7 SGTC_800 3448-7362 4.42 155.0 µM 2.77E-5 translation 125 5.02E-6
8 SGTC_1448 4255-0083 4.38 152.0 µM 3.18E-5 ERG2 11 5.91E-6
9 SGTC_2037 5169046 4.36 200.0 µM 3.43E-5 60S ribosome export 8 6.47E-6
10 SGTC_2559 tetrahydrosappanone a trimethyl ether 4.33 100.0 µM 3.92E-5 7 7.59E-6
11 SGTC_1198 1612-1005 4.31 86.7 µM 4.23E-5 5 8.29E-6
12 SGTC_1889 st059080 4.02 5.2 µM 1.22E-4 13 2.94E-5
13 SGTC_2925 9010536 3.97 32.5 µM 1.46E-4 azole & statin 50 3.62E-5
14 SGTC_2567 aureobasidin a 3.97 60.0 nM 1.47E-4 97 3.65E-5
15 SGTC_1622 st003707 3.95 19.4 µM 1.53E-4 calcium & mitochondrial duress 39 3.83E-5
16 SGTC_762 1165-0429 3.88 115.0 µM 1.97E-4 TSC3-RPN4 20 5.15E-5
17 SGTC_2134 5324836 3.83 1.5 µM 2.34E-4 17 6.35E-5
18 SGTC_1225 1216-0074 3.83 20.6 µM 2.36E-4 27 6.41E-5
19 SGTC_266 formosanin C 3.77 406.0 nM 2.89E-4 sphingolipid biosynthesis & PDR1 73 8.14E-5
20 SGTC_2106 5357045 3.74 167.3 µM 3.20E-4 24 9.21E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.79E-28 YDR516C EMI2 hom Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.163 2.15E-21 YER016W BIM1 hom Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
0.152 9.09E-19 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.138 1.14E-15 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.135 3.49E-15 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.135 4.05E-15 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.134 5.64E-15 YDR414C ERD1 hom Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
0.133 1.26E-14 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.132 1.62E-14 YGL251C HFM1 hom Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
0.132 1.96E-14 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.131 2.69E-14 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.130 4.26E-14 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.129 5.28E-14 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.129 8.28E-14 YBR162C TOS1 hom Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
0.128 1.08E-13 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit