YDR282C_p

Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR282C / YDR282C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:4.28|P-value:7.06E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.19|P-value:1.61E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-2.77|P-value:9.06E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.22|P-value:1.42E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.11|P-value:1.80E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.90|P-value:5.43E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.04|P-value:2.97E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.69|P-value:1.56E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.71|P-value:1.40E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.36|P-value:7.63E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.43|P-value:5.58E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:-2.93|P-value:4.78E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.11|P-value:1.76E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.42|P-value:5.60E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.15|P-value:1.94E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.97|P-value:3.77E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:4.32|P-value:5.41E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:3.30|P-value:9.70E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.05|P-value:2.49E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:2.89|P-value:5.57E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.04|P-value:3.00E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.84|P-value:6.76E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.84|P-value:7.56E-6 ID:SGTC_1210|Compound:3013-0140|FD-Score:2.80|P-value:7.98E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.84|P-value:6.70E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.48|P-value:4.39E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.41|P-value:6.09E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.54|P-value:3.24E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.92|P-value:5.01E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:2.86|P-value:6.20E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.95|P-value:4.37E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.79|P-value:3.51E-8 ID:SGTC_1526|Compound:st051518|FD-Score:-4.12|P-value:1.70E-6 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.35|P-value:7.88E-5 ID:SGTC_1759|Compound:st043059|FD-Score:-3.61|P-value:2.34E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.14|P-value:2.06E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.42|P-value:5.98E-5 ID:SGTC_2311|Compound:7694451|FD-Score:-3.91|P-value:5.43E-6 ID:SGTC_2312|Compound:7706453|FD-Score:4.18|P-value:1.21E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.94|P-value:4.43E-6 ID:SGTC_2381|Compound:9035592|FD-Score:2.93|P-value:4.69E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.81|P-value:7.73E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.02|P-value:2.97E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.26|P-value:1.20E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.36|P-value:7.26E-10 ID:SGTC_2993|Compound:9054257|FD-Score:3.86|P-value:6.86E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.62|P-value:2.19E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.33|P-value:8.63E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-3.72|P-value:1.43E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.96|P-value:4.01E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-5.29|P-value:1.29E-9 ID:SGTC_65|Compound:0798-0905|FD-Score:4.28|P-value:7.06E-7 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.19|P-value:1.61E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-2.77|P-value:9.06E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:3.22|P-value:1.42E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.11|P-value:1.80E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.90|P-value:5.43E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.04|P-value:2.97E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.69|P-value:1.56E-5 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.71|P-value:1.40E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.36|P-value:7.63E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:3.43|P-value:5.58E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:-2.93|P-value:4.78E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:4.11|P-value:1.76E-6 ID:SGTC_749|Compound:1000-0129|FD-Score:3.42|P-value:5.60E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.15|P-value:1.94E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.97|P-value:3.77E-6 ID:SGTC_875|Compound:0709-0210|FD-Score:4.32|P-value:5.41E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:3.30|P-value:9.70E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.05|P-value:2.49E-6 ID:SGTC_1040|Compound:k898-0338|FD-Score:2.89|P-value:5.57E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.04|P-value:3.00E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:2.84|P-value:6.76E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.84|P-value:7.56E-6 ID:SGTC_1210|Compound:3013-0140|FD-Score:2.80|P-value:7.98E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.84|P-value:6.70E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-3.48|P-value:4.39E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.41|P-value:6.09E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.54|P-value:3.24E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.92|P-value:5.01E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:2.86|P-value:6.20E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:2.95|P-value:4.37E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:-4.79|P-value:3.51E-8 ID:SGTC_1526|Compound:st051518|FD-Score:-4.12|P-value:1.70E-6 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.35|P-value:7.88E-5 ID:SGTC_1759|Compound:st043059|FD-Score:-3.61|P-value:2.34E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.14|P-value:2.06E-4 ID:SGTC_2299|Compound:7976368|FD-Score:-3.42|P-value:5.98E-5 ID:SGTC_2311|Compound:7694451|FD-Score:-3.91|P-value:5.43E-6 ID:SGTC_2312|Compound:7706453|FD-Score:4.18|P-value:1.21E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.94|P-value:4.43E-6 ID:SGTC_2381|Compound:9035592|FD-Score:2.93|P-value:4.69E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.81|P-value:7.73E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-4.02|P-value:2.97E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.26|P-value:1.20E-4 ID:SGTC_2799|Compound:7812892|FD-Score:5.36|P-value:7.26E-10 ID:SGTC_2993|Compound:9054257|FD-Score:3.86|P-value:6.86E-6 ID:SGTC_2999|Compound:9069765|FD-Score:3.62|P-value:2.19E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.33|P-value:8.63E-5 ID:SGTC_3345|Compound:9148410|FD-Score:-3.72|P-value:1.43E-5 ID:SGTC_3350|Compound:9150499|FD-Score:-3.96|P-value:4.01E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-5.29|P-value:1.29E-9

Top fitness defect scores for YDR282C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2799 7812892 5.36 81.8 µM 7.26E-10 superoxide 13 4.05E-8
2 SGTC_875 0709-0210 4.32 25.7 µM 5.41E-7 fatty acid desaturase (OLE1) 25 7.68E-6
3 SGTC_65 0798-0905 4.28 35.0 µM 7.06E-7 calcium & mitochondrial duress 75 9.48E-6
4 SGTC_2312 7706453 4.18 155.7 µM 1.21E-6 23 1.45E-5
5 SGTC_699 0375-0592 4.11 111.0 µM 1.76E-6 iron homeostasis 15 1.96E-5
6 SGTC_867 0518-0118 3.97 155.0 µM 3.77E-6 DNA intercalators 20 3.59E-5
7 SGTC_2329 6138490 3.94 200.0 µM 4.43E-6 30 4.08E-5
8 SGTC_1354 1498-1681 3.92 81.0 µM 5.01E-6 19 4.50E-5
9 SGTC_2993 9054257 3.86 71.4 µM 6.86E-6 fatty acid desaturase (OLE1) 47 5.78E-5
10 SGTC_1091 telmisartan 3.84 47.6 µM 7.56E-6 17 6.24E-5
11 SGTC_585 0kpi-0023 3.71 191.0 µM 1.40E-5 22 1.02E-4
12 SGTC_570 0987-0065 3.69 62.6 µM 1.56E-5 60S ribosome export 10 1.11E-4
13 SGTC_2999 9069765 3.62 71.4 µM 2.19E-5 amide catabolism 39 1.45E-4
14 SGTC_1346 1488-2224 3.54 62.4 µM 3.24E-5 26 1.99E-4
15 SGTC_685 1278-0033 3.43 54.9 µM 5.58E-5 60S ribosome export 43 3.07E-4
16 SGTC_749 1000-0129 3.42 128.0 µM 5.60E-5 amide catabolism 35 3.08E-4
17 SGTC_1309 pyrazolanthrone 3.41 13.4 µM 6.09E-5 37 3.29E-4
18 SGTC_1542 7-hydroxy-3'-methoxyflavone 3.35 49.7 µM 7.88E-5 36 4.04E-4
19 SGTC_3344 9148862 3.33 3.9 µM 8.63E-5 26 4.34E-4
20 SGTC_955 1216-0110 3.30 33.0 µM 9.70E-5 sphingolipid biosynthesis & PDR1 105 4.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.52E-16 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.137 1.66E-15 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.128 9.98E-14 YDR504C SPG3 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.108 3.08E-10 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.093 6.69E-8 YIL069C RPS24B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
0.089 2.79E-7 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.088 3.79E-7 YGR203W YCH1 hom Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.087 4.43E-7 YNL135C FPR1 hom Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
0.085 9.04E-7 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.084 1.02E-6 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.082 2.00E-6 YBR108W AIM3 hom Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.081 2.33E-6 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.080 3.45E-6 YIL013C PDR11 hom ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth
0.080 3.54E-6 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.080 3.77E-6 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress