YDR283C / GCN2

Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR283C / GCN2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.02|P-value:4.11E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.51|P-value:2.05E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.07|P-value:3.54E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:9.10|P-value:4.18E-13 ID:SGTC_41|Compound:0478-0632|FD-Score:7.80|P-value:4.31E-10 ID:SGTC_50|Compound:0929-0078|FD-Score:9.16|P-value:2.92E-13 ID:SGTC_51|Compound:1013-0126|FD-Score:9.32|P-value:1.11E-13 ID:SGTC_68|Compound:0986-0284|FD-Score:12.70|P-value:8.96E-24 ID:SGTC_79|Compound:0052-0007|FD-Score:5.35|P-value:1.33E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:5.72|P-value:3.59E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:19.90|P-value:1.55E-55 ID:SGTC_155|Compound:k072-0202|FD-Score:6.37|P-value:2.84E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:4.55|P-value:1.83E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:6.00|P-value:1.26E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:8.18|P-value:6.12E-11 ID:SGTC_180|Compound:1486-1293|FD-Score:13.30|P-value:7.02E-26 ID:SGTC_204|Compound:1543-0184|FD-Score:4.38|P-value:3.02E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-6.23|P-value:3.71E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:10.40|P-value:1.08E-16 ID:SGTC_285|Compound:1486-1325|FD-Score:10.60|P-value:4.34E-17 ID:SGTC_296|Compound:1222-0039|FD-Score:8.08|P-value:1.03E-10 ID:SGTC_298|Compound:1391-0729|FD-Score:6.52|P-value:1.50E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:8.22|P-value:5.20E-11 ID:SGTC_343|Compound:4130-2827|FD-Score:5.47|P-value:8.74E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:8.74|P-value:3.04E-12 ID:SGTC_352|Compound:k048-0007|FD-Score:4.71|P-value:1.11E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:6.45|P-value:2.00E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:6.59|P-value:1.14E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.84|P-value:7.31E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.08|P-value:7.03E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:5.32|P-value:1.52E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.42|P-value:2.72E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:9.89|P-value:3.44E-15 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:6.76|P-value:5.53E-8 ID:SGTC_480|Compound:am 92016|FD-Score:-4.49|P-value:1.76E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:4.17|P-value:5.52E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:17.50|P-value:9.24E-44 ID:SGTC_507|Compound:nimesulide|FD-Score:4.95|P-value:5.25E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:9.81|P-value:5.97E-15 ID:SGTC_523|Compound:1934-0222|FD-Score:7.81|P-value:4.16E-10 ID:SGTC_526|Compound:4469-0568|FD-Score:12.70|P-value:7.27E-24 ID:SGTC_542|Compound:3381-0244|FD-Score:11.70|P-value:1.43E-20 ID:SGTC_596|Compound:1155-0152|FD-Score:9.78|P-value:7.13E-15 ID:SGTC_601|Compound:0986-0029|FD-Score:8.30|P-value:3.28E-11 ID:SGTC_603|Compound:3794-0023|FD-Score:5.45|P-value:9.37E-6 ID:SGTC_609|Compound:0986-0026|FD-Score:6.14|P-value:7.03E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:4.32|P-value:3.63E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.57|P-value:1.73E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:5.38|P-value:1.23E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:6.51|P-value:1.59E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:5.62|P-value:5.14E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:4.29|P-value:3.94E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:11.20|P-value:8.08E-19 ID:SGTC_649|Compound:1123-0311|FD-Score:5.93|P-value:1.65E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:7.91|P-value:2.50E-10 ID:SGTC_689|Compound:0833-0039|FD-Score:7.01|P-value:1.85E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.96|P-value:7.86E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:10.50|P-value:7.92E-17 ID:SGTC_723|Compound:4182-0001|FD-Score:7.05|P-value:1.54E-8 ID:SGTC_727|Compound:3032-0951|FD-Score:5.29|P-value:1.66E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:5.50|P-value:8.11E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:5.13|P-value:2.84E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:10.40|P-value:1.86E-16 ID:SGTC_792|Compound:4534-1957|FD-Score:7.53|P-value:1.58E-9 ID:SGTC_807|Compound:1315-0151|FD-Score:4.35|P-value:3.32E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:9.31|P-value:1.18E-13 ID:SGTC_820|Compound:1582-0060|FD-Score:5.11|P-value:3.11E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:6.73|P-value:6.17E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:8.85|P-value:1.66E-12 ID:SGTC_844|Compound:0330-0132|FD-Score:5.11|P-value:3.05E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:5.10|P-value:3.23E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.08|P-value:7.05E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.99|P-value:8.87E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.05|P-value:6.16E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.10|P-value:3.13E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:4.93|P-value:5.57E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.87|P-value:6.67E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:5.54|P-value:6.96E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:4.97|P-value:4.92E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:4.12|P-value:6.32E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:9.99|P-value:1.89E-15 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.88|P-value:6.57E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.81|P-value:4.37E-8 ID:SGTC_1041|Compound:0206-0046|FD-Score:12.30|P-value:2.41E-22 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.10|P-value:3.21E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.12|P-value:6.29E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.43|P-value:1.65E-11 ID:SGTC_1072|Compound:oxiconazole|FD-Score:10.90|P-value:4.53E-18 ID:SGTC_1076|Compound:itraconazole|FD-Score:6.63|P-value:9.54E-8 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.36|P-value:3.18E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.83|P-value:7.63E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:9.67|P-value:1.39E-14 ID:SGTC_1114|Compound:scopoletin|FD-Score:5.41|P-value:1.11E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.91|P-value:5.99E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.02|P-value:8.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.96|P-value:9.72E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.29|P-value:3.95E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:9.06|P-value:5.23E-13 ID:SGTC_1225|Compound:1216-0074|FD-Score:10.60|P-value:3.83E-17 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.51|P-value:2.07E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.95|P-value:5.21E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.02|P-value:8.38E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.82|P-value:2.42E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:9.26|P-value:1.59E-13 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.10|P-value:3.19E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.79|P-value:8.56E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:10.50|P-value:6.02E-17 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.65|P-value:4.65E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:7.27|P-value:5.56E-9 ID:SGTC_1482|Compound:3346-2049|FD-Score:12.90|P-value:1.07E-24 ID:SGTC_1496|Compound:4469-0713|FD-Score:6.19|P-value:5.87E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.38|P-value:1.22E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:5.89|P-value:1.90E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:4.09|P-value:6.86E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:11.60|P-value:4.69E-20 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.68|P-value:4.20E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.56|P-value:1.40E-9 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.54|P-value:1.87E-4 ID:SGTC_1617|Compound:st002906|FD-Score:7.56|P-value:1.40E-9 ID:SGTC_1636|Compound:st007707|FD-Score:9.97|P-value:2.21E-15 ID:SGTC_1649|Compound:st011737|FD-Score:8.78|P-value:2.49E-12 ID:SGTC_1654|Compound:st012436|FD-Score:3.98|P-value:9.20E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.54|P-value:1.85E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.23|P-value:4.64E-4 ID:SGTC_1673|Compound:st016611|FD-Score:5.89|P-value:1.91E-6 ID:SGTC_1697|Compound:st025554|FD-Score:9.64|P-value:1.61E-14 ID:SGTC_1699|Compound:st031318|FD-Score:4.67|P-value:1.25E-4 ID:SGTC_1715|Compound:st032160|FD-Score:9.82|P-value:5.57E-15 ID:SGTC_1757|Compound:st041620|FD-Score:7.08|P-value:1.29E-8 ID:SGTC_1797|Compound:st048695|FD-Score:6.21|P-value:5.41E-7 ID:SGTC_1881|Compound:5652484|FD-Score:8.92|P-value:1.16E-12 ID:SGTC_1882|Compound:5615643|FD-Score:7.80|P-value:4.37E-10 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:11.80|P-value:6.52E-21 ID:SGTC_1906|Compound:st060206|FD-Score:5.11|P-value:3.10E-5 ID:SGTC_1907|Compound:st060210|FD-Score:4.05|P-value:7.59E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.98|P-value:2.05E-8 ID:SGTC_1921|Compound:5740136|FD-Score:5.32|P-value:1.50E-5 ID:SGTC_1937|Compound:st074714|FD-Score:6.74|P-value:5.87E-8 ID:SGTC_1975|Compound:st070967|FD-Score:4.89|P-value:6.37E-5 ID:SGTC_1999|Compound:st074831|FD-Score:9.21|P-value:2.20E-13 ID:SGTC_2002|Compound:4023503|FD-Score:4.14|P-value:6.02E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-6.32|P-value:2.57E-7 ID:SGTC_2036|Compound:5160441|FD-Score:14.40|P-value:2.69E-30 ID:SGTC_2038|Compound:4100038|FD-Score:28.20|P-value:8.94E-110 ID:SGTC_2050|Compound:5263056|FD-Score:6.48|P-value:1.77E-7 ID:SGTC_2056|Compound:5235370|FD-Score:4.75|P-value:9.91E-5 ID:SGTC_2093|Compound:5331342|FD-Score:6.57|P-value:1.24E-7 ID:SGTC_2094|Compound:5332512|FD-Score:4.64|P-value:1.37E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.43|P-value:2.58E-4 ID:SGTC_2106|Compound:5357045|FD-Score:7.75|P-value:5.64E-10 ID:SGTC_2118|Compound:5526350|FD-Score:4.98|P-value:4.66E-5 ID:SGTC_2122|Compound:5258151|FD-Score:6.46|P-value:1.95E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.51|P-value:1.78E-9 ID:SGTC_2238|Compound:6671620|FD-Score:4.03|P-value:7.97E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.10|P-value:8.44E-7 ID:SGTC_2254|Compound:7938975|FD-Score:6.36|P-value:3.00E-7 ID:SGTC_2261|Compound:9010538|FD-Score:4.18|P-value:5.34E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.48|P-value:2.25E-4 ID:SGTC_2353|Compound:9059630|FD-Score:4.81|P-value:8.06E-5 ID:SGTC_2355|Compound:9061122|FD-Score:4.72|P-value:1.08E-4 ID:SGTC_2384|Compound:9036245|FD-Score:12.80|P-value:4.45E-24 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.47|P-value:2.21E-9 ID:SGTC_2428|Compound:5615643|FD-Score:11.00|P-value:1.77E-18 ID:SGTC_2437|Compound:5741531|FD-Score:6.86|P-value:3.57E-8 ID:SGTC_2445|Compound:5742597|FD-Score:7.00|P-value:1.87E-8 ID:SGTC_2447|Compound:5741742|FD-Score:4.35|P-value:3.25E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.37|P-value:3.10E-4 ID:SGTC_2472|Compound:5377652|FD-Score:9.16|P-value:2.85E-13 ID:SGTC_2488|Compound:5268135|FD-Score:7.56|P-value:1.37E-9 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.56|P-value:1.27E-7 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.92|P-value:5.71E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.38|P-value:3.00E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.77|P-value:5.21E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:8.64|P-value:5.54E-12 ID:SGTC_2607|Compound:solasodine|FD-Score:15.00|P-value:1.27E-32 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.71|P-value:6.84E-8 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.09|P-value:5.58E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:5.95|P-value:1.52E-6 ID:SGTC_2650|Compound:prasterone|FD-Score:8.00|P-value:1.58E-10 ID:SGTC_2678|Compound:equilin|FD-Score:4.95|P-value:5.18E-5 ID:SGTC_2699|Compound:st077704|FD-Score:4.58|P-value:1.66E-4 ID:SGTC_2717|Compound:st081029|FD-Score:5.67|P-value:4.35E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:8.09|P-value:9.87E-11 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:8.33|P-value:2.80E-11 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.72|P-value:1.07E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.09|P-value:6.86E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-5.12|P-value:2.28E-5 ID:SGTC_2948|Compound:9070189|FD-Score:8.68|P-value:4.24E-12 ID:SGTC_2961|Compound:9083290|FD-Score:-4.02|P-value:6.71E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.47|P-value:2.28E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.61|P-value:1.52E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-4.29|P-value:3.15E-4 ID:SGTC_3018|Compound:9082602|FD-Score:7.48|P-value:2.09E-9 ID:SGTC_3078|Compound:9116413|FD-Score:-4.58|P-value:1.33E-4 ID:SGTC_3308|Compound:9128332|FD-Score:34.30|P-value:6.12E-162 ID:SGTC_10|Compound:0279-0212|FD-Score:5.02|P-value:4.11E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.51|P-value:2.05E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:5.07|P-value:3.54E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:9.10|P-value:4.18E-13 ID:SGTC_41|Compound:0478-0632|FD-Score:7.80|P-value:4.31E-10 ID:SGTC_50|Compound:0929-0078|FD-Score:9.16|P-value:2.92E-13 ID:SGTC_51|Compound:1013-0126|FD-Score:9.32|P-value:1.11E-13 ID:SGTC_68|Compound:0986-0284|FD-Score:12.70|P-value:8.96E-24 ID:SGTC_79|Compound:0052-0007|FD-Score:5.35|P-value:1.33E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:5.72|P-value:3.59E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:19.90|P-value:1.55E-55 ID:SGTC_155|Compound:k072-0202|FD-Score:6.37|P-value:2.84E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:4.55|P-value:1.83E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:6.00|P-value:1.26E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:8.18|P-value:6.12E-11 ID:SGTC_180|Compound:1486-1293|FD-Score:13.30|P-value:7.02E-26 ID:SGTC_204|Compound:1543-0184|FD-Score:4.38|P-value:3.02E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-6.23|P-value:3.71E-7 ID:SGTC_278|Compound:4092-0821|FD-Score:10.40|P-value:1.08E-16 ID:SGTC_285|Compound:1486-1325|FD-Score:10.60|P-value:4.34E-17 ID:SGTC_296|Compound:1222-0039|FD-Score:8.08|P-value:1.03E-10 ID:SGTC_298|Compound:1391-0729|FD-Score:6.52|P-value:1.50E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:8.22|P-value:5.20E-11 ID:SGTC_343|Compound:4130-2827|FD-Score:5.47|P-value:8.74E-6 ID:SGTC_346|Compound:4513-0042|FD-Score:8.74|P-value:3.04E-12 ID:SGTC_352|Compound:k048-0007|FD-Score:4.71|P-value:1.11E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:6.45|P-value:2.00E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:6.59|P-value:1.14E-7 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.84|P-value:7.31E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.08|P-value:7.03E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:5.32|P-value:1.52E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:4.42|P-value:2.72E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:9.89|P-value:3.44E-15 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:6.76|P-value:5.53E-8 ID:SGTC_480|Compound:am 92016|FD-Score:-4.49|P-value:1.76E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:4.17|P-value:5.52E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:17.50|P-value:9.24E-44 ID:SGTC_507|Compound:nimesulide|FD-Score:4.95|P-value:5.25E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:9.81|P-value:5.97E-15 ID:SGTC_523|Compound:1934-0222|FD-Score:7.81|P-value:4.16E-10 ID:SGTC_526|Compound:4469-0568|FD-Score:12.70|P-value:7.27E-24 ID:SGTC_542|Compound:3381-0244|FD-Score:11.70|P-value:1.43E-20 ID:SGTC_596|Compound:1155-0152|FD-Score:9.78|P-value:7.13E-15 ID:SGTC_601|Compound:0986-0029|FD-Score:8.30|P-value:3.28E-11 ID:SGTC_603|Compound:3794-0023|FD-Score:5.45|P-value:9.37E-6 ID:SGTC_609|Compound:0986-0026|FD-Score:6.14|P-value:7.03E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:4.32|P-value:3.63E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:4.57|P-value:1.73E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:5.38|P-value:1.23E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:6.51|P-value:1.59E-7 ID:SGTC_639|Compound:0833-0042|FD-Score:5.62|P-value:5.14E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:4.29|P-value:3.94E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:11.20|P-value:8.08E-19 ID:SGTC_649|Compound:1123-0311|FD-Score:5.93|P-value:1.65E-6 ID:SGTC_677|Compound:0929-0063|FD-Score:7.91|P-value:2.50E-10 ID:SGTC_689|Compound:0833-0039|FD-Score:7.01|P-value:1.85E-8 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.96|P-value:7.86E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:10.50|P-value:7.92E-17 ID:SGTC_723|Compound:4182-0001|FD-Score:7.05|P-value:1.54E-8 ID:SGTC_727|Compound:3032-0951|FD-Score:5.29|P-value:1.66E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:5.50|P-value:8.11E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:5.13|P-value:2.84E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:10.40|P-value:1.86E-16 ID:SGTC_792|Compound:4534-1957|FD-Score:7.53|P-value:1.58E-9 ID:SGTC_807|Compound:1315-0151|FD-Score:4.35|P-value:3.32E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:9.31|P-value:1.18E-13 ID:SGTC_820|Compound:1582-0060|FD-Score:5.11|P-value:3.11E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:6.73|P-value:6.17E-8 ID:SGTC_834|Compound:0312-0008|FD-Score:8.85|P-value:1.66E-12 ID:SGTC_844|Compound:0330-0132|FD-Score:5.11|P-value:3.05E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:5.10|P-value:3.23E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:4.08|P-value:7.05E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.99|P-value:8.87E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.05|P-value:6.16E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:5.10|P-value:3.13E-5 ID:SGTC_933|Compound:2914-0560|FD-Score:4.93|P-value:5.57E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.87|P-value:6.67E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:5.54|P-value:6.96E-6 ID:SGTC_971|Compound:1315-0384|FD-Score:4.97|P-value:4.92E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:4.12|P-value:6.32E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:9.99|P-value:1.89E-15 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.88|P-value:6.57E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:6.81|P-value:4.37E-8 ID:SGTC_1041|Compound:0206-0046|FD-Score:12.30|P-value:2.41E-22 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.10|P-value:3.21E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.12|P-value:6.29E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.43|P-value:1.65E-11 ID:SGTC_1072|Compound:oxiconazole|FD-Score:10.90|P-value:4.53E-18 ID:SGTC_1076|Compound:itraconazole|FD-Score:6.63|P-value:9.54E-8 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.36|P-value:3.18E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.83|P-value:7.63E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:9.67|P-value:1.39E-14 ID:SGTC_1114|Compound:scopoletin|FD-Score:5.41|P-value:1.11E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.91|P-value:5.99E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:4.02|P-value:8.21E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.96|P-value:9.72E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.29|P-value:3.95E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:9.06|P-value:5.23E-13 ID:SGTC_1225|Compound:1216-0074|FD-Score:10.60|P-value:3.83E-17 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.51|P-value:2.07E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.95|P-value:5.21E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.02|P-value:8.38E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:5.82|P-value:2.42E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:9.26|P-value:1.59E-13 ID:SGTC_1336|Compound:1486-0901|FD-Score:5.10|P-value:3.19E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.79|P-value:8.56E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:10.50|P-value:6.02E-17 ID:SGTC_1455|Compound:4262-0120|FD-Score:5.65|P-value:4.65E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:7.27|P-value:5.56E-9 ID:SGTC_1482|Compound:3346-2049|FD-Score:12.90|P-value:1.07E-24 ID:SGTC_1496|Compound:4469-0713|FD-Score:6.19|P-value:5.87E-7 ID:SGTC_1510|Compound:1123-0200|FD-Score:5.38|P-value:1.22E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:5.89|P-value:1.90E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:4.09|P-value:6.86E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:11.60|P-value:4.69E-20 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.68|P-value:4.20E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.56|P-value:1.40E-9 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.54|P-value:1.87E-4 ID:SGTC_1617|Compound:st002906|FD-Score:7.56|P-value:1.40E-9 ID:SGTC_1636|Compound:st007707|FD-Score:9.97|P-value:2.21E-15 ID:SGTC_1649|Compound:st011737|FD-Score:8.78|P-value:2.49E-12 ID:SGTC_1654|Compound:st012436|FD-Score:3.98|P-value:9.20E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.54|P-value:1.85E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.23|P-value:4.64E-4 ID:SGTC_1673|Compound:st016611|FD-Score:5.89|P-value:1.91E-6 ID:SGTC_1697|Compound:st025554|FD-Score:9.64|P-value:1.61E-14 ID:SGTC_1699|Compound:st031318|FD-Score:4.67|P-value:1.25E-4 ID:SGTC_1715|Compound:st032160|FD-Score:9.82|P-value:5.57E-15 ID:SGTC_1757|Compound:st041620|FD-Score:7.08|P-value:1.29E-8 ID:SGTC_1797|Compound:st048695|FD-Score:6.21|P-value:5.41E-7 ID:SGTC_1881|Compound:5652484|FD-Score:8.92|P-value:1.16E-12 ID:SGTC_1882|Compound:5615643|FD-Score:7.80|P-value:4.37E-10 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:11.80|P-value:6.52E-21 ID:SGTC_1906|Compound:st060206|FD-Score:5.11|P-value:3.10E-5 ID:SGTC_1907|Compound:st060210|FD-Score:4.05|P-value:7.59E-4 ID:SGTC_1909|Compound:st060837|FD-Score:6.98|P-value:2.05E-8 ID:SGTC_1921|Compound:5740136|FD-Score:5.32|P-value:1.50E-5 ID:SGTC_1937|Compound:st074714|FD-Score:6.74|P-value:5.87E-8 ID:SGTC_1975|Compound:st070967|FD-Score:4.89|P-value:6.37E-5 ID:SGTC_1999|Compound:st074831|FD-Score:9.21|P-value:2.20E-13 ID:SGTC_2002|Compound:4023503|FD-Score:4.14|P-value:6.02E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-6.32|P-value:2.57E-7 ID:SGTC_2036|Compound:5160441|FD-Score:14.40|P-value:2.69E-30 ID:SGTC_2038|Compound:4100038|FD-Score:28.20|P-value:8.94E-110 ID:SGTC_2050|Compound:5263056|FD-Score:6.48|P-value:1.77E-7 ID:SGTC_2056|Compound:5235370|FD-Score:4.75|P-value:9.91E-5 ID:SGTC_2093|Compound:5331342|FD-Score:6.57|P-value:1.24E-7 ID:SGTC_2094|Compound:5332512|FD-Score:4.64|P-value:1.37E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.43|P-value:2.58E-4 ID:SGTC_2106|Compound:5357045|FD-Score:7.75|P-value:5.64E-10 ID:SGTC_2118|Compound:5526350|FD-Score:4.98|P-value:4.66E-5 ID:SGTC_2122|Compound:5258151|FD-Score:6.46|P-value:1.95E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:7.51|P-value:1.78E-9 ID:SGTC_2238|Compound:6671620|FD-Score:4.03|P-value:7.97E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.10|P-value:8.44E-7 ID:SGTC_2254|Compound:7938975|FD-Score:6.36|P-value:3.00E-7 ID:SGTC_2261|Compound:9010538|FD-Score:4.18|P-value:5.34E-4 ID:SGTC_2301|Compound:7769476|FD-Score:4.48|P-value:2.25E-4 ID:SGTC_2353|Compound:9059630|FD-Score:4.81|P-value:8.06E-5 ID:SGTC_2355|Compound:9061122|FD-Score:4.72|P-value:1.08E-4 ID:SGTC_2384|Compound:9036245|FD-Score:12.80|P-value:4.45E-24 ID:SGTC_2409|Compound:alverine citrate|FD-Score:7.47|P-value:2.21E-9 ID:SGTC_2428|Compound:5615643|FD-Score:11.00|P-value:1.77E-18 ID:SGTC_2437|Compound:5741531|FD-Score:6.86|P-value:3.57E-8 ID:SGTC_2445|Compound:5742597|FD-Score:7.00|P-value:1.87E-8 ID:SGTC_2447|Compound:5741742|FD-Score:4.35|P-value:3.25E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:4.37|P-value:3.10E-4 ID:SGTC_2472|Compound:5377652|FD-Score:9.16|P-value:2.85E-13 ID:SGTC_2488|Compound:5268135|FD-Score:7.56|P-value:1.37E-9 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:6.56|P-value:1.27E-7 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.92|P-value:5.71E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.38|P-value:3.00E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:6.77|P-value:5.21E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:8.64|P-value:5.54E-12 ID:SGTC_2607|Compound:solasodine|FD-Score:15.00|P-value:1.27E-32 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.71|P-value:6.84E-8 ID:SGTC_2629|Compound:bisabolol|FD-Score:-4.09|P-value:5.58E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:5.95|P-value:1.52E-6 ID:SGTC_2650|Compound:prasterone|FD-Score:8.00|P-value:1.58E-10 ID:SGTC_2678|Compound:equilin|FD-Score:4.95|P-value:5.18E-5 ID:SGTC_2699|Compound:st077704|FD-Score:4.58|P-value:1.66E-4 ID:SGTC_2717|Compound:st081029|FD-Score:5.67|P-value:4.35E-6 ID:SGTC_2725|Compound:haloperidol|FD-Score:8.09|P-value:9.87E-11 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:8.33|P-value:2.80E-11 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.72|P-value:1.07E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.09|P-value:6.86E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-5.12|P-value:2.28E-5 ID:SGTC_2948|Compound:9070189|FD-Score:8.68|P-value:4.24E-12 ID:SGTC_2961|Compound:9083290|FD-Score:-4.02|P-value:6.71E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.47|P-value:2.28E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.61|P-value:1.52E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-4.29|P-value:3.15E-4 ID:SGTC_3018|Compound:9082602|FD-Score:7.48|P-value:2.09E-9 ID:SGTC_3078|Compound:9116413|FD-Score:-4.58|P-value:1.33E-4 ID:SGTC_3308|Compound:9128332|FD-Score:34.30|P-value:6.12E-162

Top fitness defect scores for YDR283C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3308 9128332 34.30 17.6 µM 6.12E-162 plasma membrane duress 1 1.22E-258
2 SGTC_2038 4100038 28.20 31.0 µM 8.94E-110 plasma membrane duress 1 5.41E-175
3 SGTC_152 4469-0003 19.90 551.2 µM 1.55E-55 1 5.01E-88
4 SGTC_505 gw-5074 17.50 63.9 µM 9.24E-44 6 3.78E-69
5 SGTC_2607 solasodine 15.00 47.4 µM 1.27E-32 7 2.69E-51
6 SGTC_2036 5160441 14.40 105.0 µM 2.69E-30 NEO1 8 1.43E-47
7 SGTC_180 1486-1293 13.30 102.8 µM 7.02E-26 8 1.70E-40
8 SGTC_1482 3346-2049 12.90 8.5 µM 1.07E-24 7 1.34E-38
9 SGTC_2384 9036245 12.80 200.0 µM 4.45E-24 6 1.31E-37
10 SGTC_526 4469-0568 12.70 170.0 µM 7.27E-24 azole & statin 3 2.87E-37
11 SGTC_68 0986-0284 12.70 82.8 µM 8.96E-24 4 4.01E-37
12 SGTC_1041 0206-0046 12.30 107.0 µM 2.41E-22 3 7.82E-35
13 SGTC_1883 5-benzylidenerhodanine 11.80 20.0 µM 6.52E-21 TRP & mitochondrial translation 10 1.53E-32
14 SGTC_542 3381-0244 11.70 89.3 µM 1.43E-20 4 5.36E-32
15 SGTC_1572 epiandrosterone 11.60 68.9 µM 4.69E-20 6 3.60E-31
16 SGTC_646 4092-0839 11.20 27.3 µM 8.08E-19 plasma membrane duress 3 3.43E-29
17 SGTC_2428 5615643 11.00 7.8 µM 1.77E-18 2 1.21E-28
18 SGTC_1072 oxiconazole 10.90 14.9 nM 4.53E-18 ergosterol depletion effects on membrane 4 5.41E-28
19 SGTC_1225 1216-0074 10.60 20.6 µM 3.83E-17 2 1.65E-26
20 SGTC_285 1486-1325 10.60 46.0 µM 4.34E-17 2 2.02E-26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.648 0 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.634 0 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.634 0 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.629 0 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.621 0 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.583 1.16E-303 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.547 1.00E-260 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.541 4.26E-253 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.540 1.60E-251 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.527 1.09E-238 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.503 9.47E-214 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.489 1.64E-200 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.341 6.65E-92 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.231 5.43E-42 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.192 2.98E-29 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication