YDR284C / DPP1

Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR284C / DPP1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.89|P-value:3.44E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.02|P-value:9.69E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.03|P-value:9.50E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.08|P-value:8.21E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.06|P-value:1.58E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:3.41|P-value:2.39E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.29|P-value:3.67E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.13|P-value:1.18E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.25|P-value:4.34E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.40|P-value:2.51E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.11|P-value:7.26E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.52|P-value:1.57E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:5.22|P-value:4.42E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.38|P-value:2.73E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.04|P-value:9.21E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.04|P-value:1.73E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.98|P-value:2.16E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:3.85|P-value:4.09E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:4.79|P-value:4.56E-7 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.43|P-value:2.14E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:4.25|P-value:6.78E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.10|P-value:7.21E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.10|P-value:1.37E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.16|P-value:5.97E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:6.83|P-value:1.34E-12 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.73|P-value:6.59E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.37|P-value:2.72E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.06|P-value:8.77E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.57|P-value:1.22E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.02|P-value:9.98E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-4.23|P-value:7.16E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.22|P-value:4.72E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.13|P-value:1.19E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.72|P-value:7.01E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.45|P-value:2.06E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:7.29|P-value:4.13E-14 ID:SGTC_1804|Compound:st050076|FD-Score:3.18|P-value:5.65E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.46|P-value:2.42E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.73|P-value:6.45E-7 ID:SGTC_2371|Compound:9071574|FD-Score:4.88|P-value:2.89E-7 ID:SGTC_2377|Compound:9073351|FD-Score:-4.90|P-value:2.47E-7 ID:SGTC_2378|Compound:9074213|FD-Score:-3.33|P-value:3.11E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.29|P-value:3.68E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.86|P-value:9.64E-10 ID:SGTC_2386|Compound:9075165|FD-Score:5.85|P-value:1.06E-9 ID:SGTC_2442|Compound:5158906|FD-Score:4.60|P-value:1.22E-6 ID:SGTC_2448|Compound:5185112|FD-Score:5.37|P-value:1.89E-8 ID:SGTC_2451|Compound:5856223|FD-Score:-3.48|P-value:1.79E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.02|P-value:1.34E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.39|P-value:2.64E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.22|P-value:4.65E-4 ID:SGTC_2839|Compound:9003951|FD-Score:5.98|P-value:4.56E-10 ID:SGTC_2852|Compound:9023854|FD-Score:4.21|P-value:8.18E-6 ID:SGTC_2857|Compound:9024691|FD-Score:-6.00|P-value:3.59E-10 ID:SGTC_3215|Compound:9129942|FD-Score:3.30|P-value:3.64E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.89|P-value:3.44E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.02|P-value:9.69E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:3.03|P-value:9.50E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.08|P-value:8.21E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.06|P-value:1.58E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:3.41|P-value:2.39E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.29|P-value:3.67E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.13|P-value:1.18E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.25|P-value:4.34E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.40|P-value:2.51E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.11|P-value:7.26E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.52|P-value:1.57E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:5.22|P-value:4.42E-8 ID:SGTC_535|Compound:2293-4129|FD-Score:3.38|P-value:2.73E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:3.04|P-value:9.21E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.28|P-value:3.89E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.04|P-value:1.73E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.98|P-value:2.16E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:3.85|P-value:4.09E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:4.79|P-value:4.56E-7 ID:SGTC_779|Compound:1360-0071|FD-Score:-3.43|P-value:2.14E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:4.25|P-value:6.78E-6 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.10|P-value:7.21E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.10|P-value:1.37E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.16|P-value:5.97E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:6.83|P-value:1.34E-12 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.73|P-value:6.59E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:-3.37|P-value:2.72E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.06|P-value:8.77E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.57|P-value:1.22E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.02|P-value:9.98E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-4.23|P-value:7.16E-6 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.35|P-value:2.98E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.22|P-value:4.72E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:4.13|P-value:1.19E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.72|P-value:7.01E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.45|P-value:2.06E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:7.29|P-value:4.13E-14 ID:SGTC_1804|Compound:st050076|FD-Score:3.18|P-value:5.65E-4 ID:SGTC_2046|Compound:4110841|FD-Score:3.35|P-value:3.02E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.46|P-value:2.42E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.73|P-value:6.45E-7 ID:SGTC_2371|Compound:9071574|FD-Score:4.88|P-value:2.89E-7 ID:SGTC_2377|Compound:9073351|FD-Score:-4.90|P-value:2.47E-7 ID:SGTC_2378|Compound:9074213|FD-Score:-3.33|P-value:3.11E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.29|P-value:3.68E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.86|P-value:9.64E-10 ID:SGTC_2386|Compound:9075165|FD-Score:5.85|P-value:1.06E-9 ID:SGTC_2442|Compound:5158906|FD-Score:4.60|P-value:1.22E-6 ID:SGTC_2448|Compound:5185112|FD-Score:5.37|P-value:1.89E-8 ID:SGTC_2451|Compound:5856223|FD-Score:-3.48|P-value:1.79E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:5.02|P-value:1.34E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.39|P-value:2.64E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-3.22|P-value:4.65E-4 ID:SGTC_2839|Compound:9003951|FD-Score:5.98|P-value:4.56E-10 ID:SGTC_2852|Compound:9023854|FD-Score:4.21|P-value:8.18E-6 ID:SGTC_2857|Compound:9024691|FD-Score:-6.00|P-value:3.59E-10 ID:SGTC_3215|Compound:9129942|FD-Score:3.30|P-value:3.64E-4

Top fitness defect scores for YDR284C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 7.29 11.9 µM 4.13E-14 redox potentiating 11 1.58E-13
2 SGTC_1071 trifluoperazine 6.83 6.3 µM 1.34E-12 4 4.37E-12
3 SGTC_2839 9003951 5.98 26.0 µM 4.56E-10 4 1.13E-9
4 SGTC_2385 9074692 5.86 200.0 µM 9.64E-10 14 2.30E-9
5 SGTC_2386 9075165 5.85 157.4 µM 1.06E-9 1 2.52E-9
6 SGTC_2448 5185112 5.37 27.2 µM 1.89E-8 4 3.93E-8
7 SGTC_532 1548-0774 5.22 215.0 µM 4.42E-8 4 8.84E-8
8 SGTC_2497 7-hydroxyflavone 5.02 100.0 µM 1.34E-7 7 2.55E-7
9 SGTC_2371 9071574 4.88 200.0 µM 2.89E-7 6 5.29E-7
10 SGTC_775 4577-0580 4.79 57.3 µM 4.56E-7 3 8.18E-7
11 SGTC_2332 7982454 4.73 138.9 µM 6.45E-7 31 1.14E-6
12 SGTC_2442 5158906 4.60 48.5 µM 1.22E-6 11 2.10E-6
13 SGTC_2316 5844804 4.46 197.4 µM 2.42E-6 15 4.03E-6
14 SGTC_790 1575-0012 4.25 79.1 µM 6.78E-6 TSC3-RPN4 21 1.08E-5
15 SGTC_2852 9023854 4.21 52.0 µM 8.18E-6 28 1.29E-5
16 SGTC_359 0081-0058 4.13 15.9 µM 1.18E-5 60S ribosome export 39 1.83E-5
17 SGTC_1512 0259-0544 4.13 12.2 µM 1.19E-5 10 1.85E-5
18 SGTC_1064 honokiol 4.10 6.8 µM 1.37E-5 22 2.11E-5
19 SGTC_132 0417-1715 4.06 25.8 µM 1.58E-5 RPP1 & pyrimidine depletion 21 2.41E-5
20 SGTC_660 4031-1742 4.04 102.0 µM 1.73E-5 redox potentiating 47 2.63E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.56E-11 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.106 7.00E-10 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.097 1.70E-8 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.095 3.84E-8 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.095 3.90E-8 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.094 5.45E-8 YER073W ALD5 hom Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
0.088 3.28E-7 YJR149W_p YJR149W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.085 8.87E-7 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.084 1.03E-6 YNR058W BIO3 hom 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.082 2.20E-6 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.081 2.34E-6 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.081 2.71E-6 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 4.06E-6 YGL061C DUO1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.078 5.52E-6 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.076 1.09E-5 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication