YDR285W / ZIP1

Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR285W / ZIP1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-4.79|P-value:8.76E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.45|P-value:5.25E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.29|P-value:1.13E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.50|P-value:2.75E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.16|P-value:8.00E-4 ID:SGTC_228|Compound:caffeine|FD-Score:4.07|P-value:2.88E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.23|P-value:1.23E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.39|P-value:3.49E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:7.17|P-value:5.90E-13 ID:SGTC_548|Compound:1436-0017|FD-Score:3.46|P-value:3.14E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.02|P-value:3.53E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.25|P-value:5.81E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.32|P-value:4.52E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:5.70|P-value:8.21E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.04|P-value:3.31E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.21|P-value:7.73E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.14|P-value:8.61E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.36|P-value:4.57E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.14|P-value:1.84E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:3.58|P-value:2.02E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.42|P-value:3.66E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.95|P-value:4.65E-5 ID:SGTC_2190|Compound:6049624|FD-Score:3.87|P-value:6.53E-5 ID:SGTC_2293|Compound:7624732|FD-Score:3.23|P-value:7.04E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-6.72|P-value:1.08E-11 ID:SGTC_2416|Compound:tofa|FD-Score:3.47|P-value:3.09E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.28|P-value:5.90E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.19|P-value:4.29E-10 ID:SGTC_2620|Compound:irigenin|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.21|P-value:1.57E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.57|P-value:1.82E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.54|P-value:2.88E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.33|P-value:4.38E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.47|P-value:2.65E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.06|P-value:2.56E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.93|P-value:4.38E-5 ID:SGTC_3180|Compound:9109287|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.21|P-value:6.75E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.16|P-value:7.94E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.78|P-value:9.44E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.22|P-value:7.47E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-4.79|P-value:8.76E-7 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.45|P-value:5.25E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:4.29|P-value:1.13E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.50|P-value:2.75E-4 ID:SGTC_211|Compound:3455-0679|FD-Score:-3.16|P-value:8.00E-4 ID:SGTC_228|Compound:caffeine|FD-Score:4.07|P-value:2.88E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.53|P-value:2.43E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-4.23|P-value:1.23E-5 ID:SGTC_260|Compound:nsc-65238|FD-Score:-3.39|P-value:3.49E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:7.17|P-value:5.90E-13 ID:SGTC_548|Compound:1436-0017|FD-Score:3.46|P-value:3.14E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.02|P-value:3.53E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.25|P-value:5.81E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.32|P-value:4.52E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:5.70|P-value:8.21E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.04|P-value:3.31E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.21|P-value:7.73E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.14|P-value:8.61E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.36|P-value:4.57E-4 ID:SGTC_1658|Compound:st012944|FD-Score:5.14|P-value:1.84E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:3.58|P-value:2.02E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.42|P-value:3.66E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.95|P-value:4.65E-5 ID:SGTC_2190|Compound:6049624|FD-Score:3.87|P-value:6.53E-5 ID:SGTC_2293|Compound:7624732|FD-Score:3.23|P-value:7.04E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-6.72|P-value:1.08E-11 ID:SGTC_2416|Compound:tofa|FD-Score:3.47|P-value:3.09E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.28|P-value:5.90E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.19|P-value:4.29E-10 ID:SGTC_2620|Compound:irigenin|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.21|P-value:1.57E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.57|P-value:1.82E-4 ID:SGTC_2798|Compound:7813637|FD-Score:-4.54|P-value:2.88E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.33|P-value:4.38E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.47|P-value:2.65E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.06|P-value:2.56E-5 ID:SGTC_3178|Compound:9107506|FD-Score:-3.93|P-value:4.38E-5 ID:SGTC_3180|Compound:9109287|FD-Score:-3.54|P-value:2.00E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.21|P-value:6.75E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.16|P-value:7.94E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.78|P-value:9.44E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.22|P-value:7.47E-4

Top fitness defect scores for YDR285W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 7.17 9.4 µM 5.90E-13 7 3.64E-13
2 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 6.19 70.0 µM 4.29E-10 redox potentiating 24 2.94E-10
3 SGTC_1186 1319-0216 5.70 26.0 µM 8.21E-9 4 5.90E-9
4 SGTC_1658 st012944 5.14 20.0 µM 1.84E-7 iron homeostasis 44 1.39E-7
5 SGTC_45 0kpi-0036 4.45 14.9 µM 5.25E-6 excess fatty acid 11 4.20E-6
6 SGTC_143 4032-1194 4.29 15.7 µM 1.13E-5 51 9.10E-6
7 SGTC_2434 5670830 4.27 169.9 µM 1.20E-5 19 9.70E-6
8 SGTC_2721 ifenprodil 4.21 61.4 µM 1.57E-5 plasma membrane duress 12 1.28E-5
9 SGTC_228 caffeine 4.07 993.1 µM 2.88E-5 8 2.37E-5
10 SGTC_1239 0337-0584 4.04 35.4 µM 3.31E-5 unfolded protein response 48 2.73E-5
11 SGTC_568 1193-0097 4.02 7.5 µM 3.53E-5 ERAD & cell cycle 144 2.91E-5
12 SGTC_2087 5276107 3.95 200.0 µM 4.65E-5 17 3.85E-5
13 SGTC_2190 6049624 3.87 200.0 µM 6.53E-5 4 5.44E-5
14 SGTC_3223 9129970 3.78 49.5 µM 9.44E-5 25 7.92E-5
15 SGTC_1718 roemerine 3.58 11.9 µM 2.02E-4 redox potentiating 74 1.72E-4
16 SGTC_2620 irigenin 3.58 100.0 µM 2.03E-4 51 1.73E-4
17 SGTC_238 5hr heat shock (37°C) + nsc-638432 3.53 8.9 µM 2.43E-4 heat shock/prefoldin 55 2.07E-4
18 SGTC_163 1327-0036 3.50 7.5 µM 2.75E-4 142 2.34E-4
19 SGTC_2416 tofa 3.47 880.0 nM 3.09E-4 sphingolipid biosynthesis & PDR1 69 2.65E-4
20 SGTC_548 1436-0017 3.46 110.0 µM 3.14E-4 TSC3-RPN4 56 2.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.22E-16 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.115 1.99E-11 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.111 1.22E-10 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.106 7.53E-10 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.105 1.16E-9 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.102 3.08E-9 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.102 3.24E-9 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.102 3.33E-9 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.102 3.80E-9 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.101 4.11E-9 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.099 7.69E-9 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.097 1.88E-8 YGR144W THI4 hom Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents
0.095 3.12E-8 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.093 6.42E-8 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.091 1.32E-7 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein