YDR287W / INM2

Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR287W / INM2

Click on Significant Values for Screen Details ID:SGTC_212|Compound:3807-4682|FD-Score:3.22|P-value:5.00E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.71|P-value:6.83E-7 ID:SGTC_500|Compound:h-89|FD-Score:3.49|P-value:1.82E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.23|P-value:4.91E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.29|P-value:3.94E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.29|P-value:3.06E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.38|P-value:2.77E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.14|P-value:6.83E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.03|P-value:7.85E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.35|P-value:3.05E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.64|P-value:1.01E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.40|P-value:3.22E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.09|P-value:7.95E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.96|P-value:2.50E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.12|P-value:5.58E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.80|P-value:5.03E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.75|P-value:6.26E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.17|P-value:4.74E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.67|P-value:8.73E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.88|P-value:3.54E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.42|P-value:2.32E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.66|P-value:8.90E-5 ID:SGTC_1969|Compound:st069479|FD-Score:-3.01|P-value:8.51E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.29|P-value:5.59E-6 ID:SGTC_1993|Compound:st073995|FD-Score:4.50|P-value:2.03E-6 ID:SGTC_2100|Compound:5377183|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.98|P-value:2.28E-5 ID:SGTC_2124|Compound:5246320|FD-Score:4.32|P-value:4.81E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.04|P-value:9.61E-4 ID:SGTC_2347|Compound:9049783|FD-Score:8.85|P-value:4.43E-20 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.07|P-value:8.64E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.55|P-value:1.10E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.02|P-value:1.44E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.79|P-value:4.04E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.42|P-value:2.40E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.35|P-value:2.42E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.80|P-value:5.12E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.63|P-value:7.62E-5 ID:SGTC_2956|Compound:9076196|FD-Score:4.06|P-value:1.63E-5 ID:SGTC_3169|Compound:9102970|FD-Score:3.06|P-value:9.01E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.17|P-value:5.98E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.13|P-value:7.14E-8 ID:SGTC_212|Compound:3807-4682|FD-Score:3.22|P-value:5.00E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.71|P-value:6.83E-7 ID:SGTC_500|Compound:h-89|FD-Score:3.49|P-value:1.82E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.23|P-value:4.91E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:3.29|P-value:3.94E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.29|P-value:3.06E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.38|P-value:2.77E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.14|P-value:6.83E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.03|P-value:7.85E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.35|P-value:3.05E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.64|P-value:1.01E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.40|P-value:3.22E-6 ID:SGTC_1254|Compound:0550-0035|FD-Score:3.09|P-value:7.95E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.96|P-value:2.50E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.12|P-value:5.58E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.80|P-value:5.03E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.75|P-value:6.26E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.17|P-value:4.74E-4 ID:SGTC_1852|Compound:st056254|FD-Score:3.67|P-value:8.73E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.88|P-value:3.54E-5 ID:SGTC_1956|Compound:st077085|FD-Score:3.42|P-value:2.32E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.66|P-value:8.90E-5 ID:SGTC_1969|Compound:st069479|FD-Score:-3.01|P-value:8.51E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.29|P-value:5.59E-6 ID:SGTC_1993|Compound:st073995|FD-Score:4.50|P-value:2.03E-6 ID:SGTC_2100|Compound:5377183|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.98|P-value:2.28E-5 ID:SGTC_2124|Compound:5246320|FD-Score:4.32|P-value:4.81E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.04|P-value:9.61E-4 ID:SGTC_2347|Compound:9049783|FD-Score:8.85|P-value:4.43E-20 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.07|P-value:8.64E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.55|P-value:1.10E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.02|P-value:1.44E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.79|P-value:4.04E-5 ID:SGTC_2797|Compound:7859098|FD-Score:3.42|P-value:2.40E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-3.35|P-value:2.42E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.80|P-value:5.12E-5 ID:SGTC_2859|Compound:9028643|FD-Score:-3.63|P-value:7.62E-5 ID:SGTC_2956|Compound:9076196|FD-Score:4.06|P-value:1.63E-5 ID:SGTC_3169|Compound:9102970|FD-Score:3.06|P-value:9.01E-4 ID:SGTC_3221|Compound:9128209|FD-Score:3.17|P-value:5.98E-4 ID:SGTC_3223|Compound:9129970|FD-Score:5.13|P-value:7.14E-8

Top fitness defect scores for YDR287W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2347 9049783 8.85 174.8 µM 4.43E-20 5 4.34E-19
2 SGTC_3223 9129970 5.13 49.5 µM 7.14E-8 6 1.44E-7
3 SGTC_432 NS 1619 4.71 61.3 µM 6.83E-7 13 1.22E-6
4 SGTC_1168 k815-0004 4.64 80.5 µM 1.01E-6 DNA damage response 8 1.78E-6
5 SGTC_1993 st073995 4.50 70.8 µM 2.03E-6 11 3.43E-6
6 SGTC_1170 0310-0127 4.40 64.8 µM 3.22E-6 13 5.32E-6
7 SGTC_2124 5246320 4.32 200.0 µM 4.81E-6 heme biosynthesis & mitochondrial translocase 15 7.78E-6
8 SGTC_1978 st071761 4.29 42.0 µM 5.59E-6 TSC3-RPN4 9 8.97E-6
9 SGTC_2956 9076196 4.06 2.5 µM 1.63E-5 13 2.48E-5
10 SGTC_2117 5521686 3.98 200.0 µM 2.28E-5 10 3.40E-5
11 SGTC_1282 0886-0010 3.96 32.4 µM 2.50E-5 endomembrane recycling 33 3.71E-5
12 SGTC_1853 st056710 3.88 91.2 µM 3.54E-5 amide catabolism 27 5.16E-5
13 SGTC_1727 st034309 3.80 9.9 µM 5.03E-5 48 7.20E-5
14 SGTC_2854 9024559 3.80 71.4 µM 5.12E-5 27 7.32E-5
15 SGTC_1728 st035614 3.75 33.8 µM 6.26E-5 61 8.87E-5
16 SGTC_1852 st056254 3.67 31.4 µM 8.73E-5 16 1.22E-4
17 SGTC_1957 st077035 3.66 62.4 µM 8.90E-5 22 1.24E-4
18 SGTC_500 h-89 3.49 112.0 µM 1.82E-4 cell wall signaling 44 2.45E-4
19 SGTC_1956 st077085 3.42 54.0 µM 2.32E-4 35 3.08E-4
20 SGTC_2797 7859098 3.42 81.8 µM 2.40E-4 44 3.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 1.54E-68 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.176 1.07E-24 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.148 6.57E-18 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.148 8.32E-18 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.131 3.32E-14 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.129 5.96E-14 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.110 2.03E-10 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
0.109 3.00E-10 YAR031W PRM9 hom Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
0.105 9.40E-10 YDR087C RRP1 het Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
0.102 3.84E-9 YMR125W STO1 hom Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
0.101 4.42E-9 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.091 1.31E-7 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
0.091 1.44E-7 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.090 1.66E-7 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.22E-7 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome