HIPHOP chemogenomics database
YDR288W / NSE3 
Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YDR288W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.089 | 2.24E-7 | YIL145C | PAN6 | hom | Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC |
| 0.089 | 2.74E-7 | YDR183W | PLP1 | hom | Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators |
| 0.089 | 2.80E-7 | YNR053C | NOG2 | het | Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation |
| 0.085 | 8.80E-7 | YPL114W_d | YPL114W_d | hom | Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index |
| 0.079 | 4.55E-6 | YCL064C | CHA1 | hom | Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine |
| 0.076 | 1.15E-5 | YER043C | SAH1 | het | S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor |
| 0.075 | 1.40E-5 | YEL033W_p | MTC7_p | hom | Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant |
| 0.074 | 1.85E-5 | YAR029W_p | YAR029W_p | hom | Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
| 0.073 | 2.27E-5 | YDL154W | MSH5 | hom | Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans |
| 0.073 | 2.49E-5 | YGR190C_d | YGR190C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W |
| 0.073 | 2.56E-5 | YJR005C-A_p | YJR005C-A_p | hom | Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication |
| 0.070 | 4.47E-5 | YBR155W | CNS1 | het | TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion |
| 0.069 | 5.96E-5 | YLR435W | TSR2 | hom | Protein with a potential role in pre-rRNA processing |
| 0.069 | 6.67E-5 | YGR091W | PRP31 | het | Splicing factor, component of the U4/U6-U5 snRNP complex |
| 0.069 | 7.06E-5 | YJL188C_d | BUD19_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay |