YDR290W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR290W / YDR290W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.86|P-value:4.67E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.61|P-value:3.13E-11 ID:SGTC_122|Compound:0236-0016|FD-Score:5.82|P-value:2.87E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.15|P-value:1.85E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:6.14|P-value:6.70E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:4.09|P-value:2.26E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.76|P-value:6.27E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.66|P-value:8.27E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.80|P-value:5.53E-4 ID:SGTC_398|Compound:bronopol|FD-Score:8.27|P-value:6.30E-13 ID:SGTC_444|Compound:curcumin|FD-Score:-3.68|P-value:7.79E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.06|P-value:2.33E-12 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.68|P-value:2.94E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.43|P-value:7.10E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.84|P-value:4.86E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.70|P-value:7.44E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.41|P-value:7.66E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:4.31|P-value:1.07E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.73|P-value:6.88E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.07|P-value:2.39E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.74|P-value:6.67E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.84|P-value:4.85E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.85|P-value:4.77E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.42|P-value:7.39E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.03|P-value:2.69E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.61|P-value:9.58E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.60|P-value:3.97E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.89|P-value:4.23E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.31|P-value:1.08E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.02|P-value:8.11E-6 ID:SGTC_1745|Compound:st081495|FD-Score:13.40|P-value:7.06E-31 ID:SGTC_1750|Compound:st081859|FD-Score:8.98|P-value:6.35E-15 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.29|P-value:1.17E-4 ID:SGTC_2037|Compound:5169046|FD-Score:-3.81|P-value:5.36E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.67|P-value:8.19E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.41|P-value:7.66E-5 ID:SGTC_2192|Compound:5915882|FD-Score:8.88|P-value:1.20E-14 ID:SGTC_2200|Compound:6600604|FD-Score:-3.80|P-value:5.51E-4 ID:SGTC_2220|Compound:6782180|FD-Score:6.15|P-value:6.35E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.06|P-value:7.11E-6 ID:SGTC_2289|Compound:7946404|FD-Score:5.89|P-value:2.09E-7 ID:SGTC_2333|Compound:9017922|FD-Score:5.03|P-value:7.88E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-4.08|P-value:2.28E-4 ID:SGTC_2342|Compound:7990637|FD-Score:7.80|P-value:1.05E-11 ID:SGTC_2395|Compound:5646831|FD-Score:3.92|P-value:3.87E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.98|P-value:9.61E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-3.80|P-value:5.49E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.02|P-value:2.79E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.81|P-value:5.28E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.67|P-value:8.25E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.64|P-value:8.96E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.38|P-value:8.45E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.67|P-value:3.09E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.11|P-value:2.11E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.91|P-value:3.91E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-4.25|P-value:1.31E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.84|P-value:1.60E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.72|P-value:7.10E-4 ID:SGTC_2896|Compound:9052656|FD-Score:12.40|P-value:1.01E-26 ID:SGTC_2912|Compound:7964298|FD-Score:3.75|P-value:6.38E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.68|P-value:7.91E-4 ID:SGTC_2970|Compound:9090938|FD-Score:5.15|P-value:4.92E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.85|P-value:4.66E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-5.73|P-value:4.40E-7 ID:SGTC_2997|Compound:9067075|FD-Score:6.21|P-value:4.89E-8 ID:SGTC_3018|Compound:9082602|FD-Score:4.56|P-value:4.56E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-4.19|P-value:1.59E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.88|P-value:4.38E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.20|P-value:4.09E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.62|P-value:3.70E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.16|P-value:1.77E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.75|P-value:6.41E-4 ID:SGTC_3219|Compound:9131112|FD-Score:7.78|P-value:1.17E-11 ID:SGTC_3273|Compound:9137859|FD-Score:-3.80|P-value:5.44E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-5.50|P-value:1.16E-6 ID:SGTC_3292|Compound:9120825|FD-Score:-3.86|P-value:4.65E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.63|P-value:9.11E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.53|P-value:5.07E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.83|P-value:5.10E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.09|P-value:2.21E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.86|P-value:4.67E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:7.61|P-value:3.13E-11 ID:SGTC_122|Compound:0236-0016|FD-Score:5.82|P-value:2.87E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:-4.15|P-value:1.85E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:6.14|P-value:6.70E-8 ID:SGTC_312|Compound:4092-0653|FD-Score:4.09|P-value:2.26E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.76|P-value:6.27E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.66|P-value:8.27E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.80|P-value:5.53E-4 ID:SGTC_398|Compound:bronopol|FD-Score:8.27|P-value:6.30E-13 ID:SGTC_444|Compound:curcumin|FD-Score:-3.68|P-value:7.79E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:8.06|P-value:2.33E-12 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.68|P-value:2.94E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:4.43|P-value:7.10E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:3.84|P-value:4.86E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.70|P-value:7.44E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.41|P-value:7.66E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:4.31|P-value:1.07E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.73|P-value:6.88E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.07|P-value:2.39E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.74|P-value:6.67E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.84|P-value:4.85E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.85|P-value:4.77E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:4.42|P-value:7.39E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.03|P-value:2.69E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.61|P-value:9.58E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.60|P-value:3.97E-5 ID:SGTC_1605|Compound:st000082|FD-Score:-3.89|P-value:4.23E-4 ID:SGTC_1656|Compound:st012921|FD-Score:4.31|P-value:1.08E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.02|P-value:8.11E-6 ID:SGTC_1745|Compound:st081495|FD-Score:13.40|P-value:7.06E-31 ID:SGTC_1750|Compound:st081859|FD-Score:8.98|P-value:6.35E-15 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.29|P-value:1.17E-4 ID:SGTC_2037|Compound:5169046|FD-Score:-3.81|P-value:5.36E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.67|P-value:8.19E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.41|P-value:7.66E-5 ID:SGTC_2192|Compound:5915882|FD-Score:8.88|P-value:1.20E-14 ID:SGTC_2200|Compound:6600604|FD-Score:-3.80|P-value:5.51E-4 ID:SGTC_2220|Compound:6782180|FD-Score:6.15|P-value:6.35E-8 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.06|P-value:7.11E-6 ID:SGTC_2289|Compound:7946404|FD-Score:5.89|P-value:2.09E-7 ID:SGTC_2333|Compound:9017922|FD-Score:5.03|P-value:7.88E-6 ID:SGTC_2338|Compound:7999974|FD-Score:-4.08|P-value:2.28E-4 ID:SGTC_2342|Compound:7990637|FD-Score:7.80|P-value:1.05E-11 ID:SGTC_2395|Compound:5646831|FD-Score:3.92|P-value:3.87E-4 ID:SGTC_2396|Compound:5342950|FD-Score:4.98|P-value:9.61E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-3.80|P-value:5.49E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-4.02|P-value:2.79E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-3.81|P-value:5.28E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.67|P-value:8.25E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.64|P-value:8.96E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:4.38|P-value:8.45E-5 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-4.67|P-value:3.09E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:4.11|P-value:2.11E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.91|P-value:3.91E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-4.25|P-value:1.31E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.84|P-value:1.60E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.72|P-value:7.10E-4 ID:SGTC_2896|Compound:9052656|FD-Score:12.40|P-value:1.01E-26 ID:SGTC_2912|Compound:7964298|FD-Score:3.75|P-value:6.38E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.68|P-value:7.91E-4 ID:SGTC_2970|Compound:9090938|FD-Score:5.15|P-value:4.92E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.85|P-value:4.66E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-5.73|P-value:4.40E-7 ID:SGTC_2997|Compound:9067075|FD-Score:6.21|P-value:4.89E-8 ID:SGTC_3018|Compound:9082602|FD-Score:4.56|P-value:4.56E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-4.19|P-value:1.59E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.88|P-value:4.38E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.20|P-value:4.09E-6 ID:SGTC_3143|Compound:9086658|FD-Score:4.62|P-value:3.70E-5 ID:SGTC_3149|Compound:9097855|FD-Score:4.16|P-value:1.77E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.75|P-value:6.41E-4 ID:SGTC_3219|Compound:9131112|FD-Score:7.78|P-value:1.17E-11 ID:SGTC_3273|Compound:9137859|FD-Score:-3.80|P-value:5.44E-4 ID:SGTC_3286|Compound:9117135|FD-Score:-5.50|P-value:1.16E-6 ID:SGTC_3292|Compound:9120825|FD-Score:-3.86|P-value:4.65E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.63|P-value:9.11E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.53|P-value:5.07E-5 ID:SGTC_3307|Compound:9126885|FD-Score:3.83|P-value:5.10E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-4.09|P-value:2.21E-4

Top fitness defect scores for YDR290W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1745 st081495 13.40 74.0 µM 7.06E-31 RNA processing & uracil transport 1 3.55E-41
2 SGTC_2896 9052656 12.40 71.4 µM 1.01E-26 endomembrane recycling 4 1.50E-35
3 SGTC_1750 st081859 8.98 2.4 µM 6.35E-15 endomembrane recycling 51 1.36E-19
4 SGTC_2192 5915882 8.88 198.5 µM 1.20E-14 RNA processing & uracil transport 4 3.20E-19
5 SGTC_398 bronopol 8.27 33.3 µM 6.30E-13 RNA processing & uracil transport 3 6.78E-17
6 SGTC_453 enantio-paf c16 8.06 10.0 µM 2.33E-12 12 3.97E-16
7 SGTC_2342 7990637 7.80 118.9 µM 1.05E-11 RNA processing & uracil transport 1 3.03E-15
8 SGTC_3219 9131112 7.78 49.5 µM 1.17E-11 Golgi 8 3.50E-15
9 SGTC_117 lucigenin 7.61 22.1 µM 3.13E-11 redox potentiating 21 1.32E-14
10 SGTC_2997 9067075 6.21 71.4 µM 4.89E-8 unfolded protein response 17 2.66E-10
11 SGTC_2220 6782180 6.15 200.0 µM 6.35E-8 RNA processing & uracil transport 1 3.78E-10
12 SGTC_188 3229-0966 6.14 278.5 µM 6.70E-8 8 4.06E-10
13 SGTC_2289 7946404 5.89 165.1 µM 2.09E-7 38 1.88E-9
14 SGTC_122 0236-0016 5.82 402.4 µM 2.87E-7 RNA processing & uracil transport 9 2.87E-9
15 SGTC_3098 9119039 5.20 49.5 µM 4.09E-6 Golgi 13 1.02E-7
16 SGTC_2970 9090938 5.15 41.9 µM 4.92E-6 RNA processing & uracil transport 10 1.31E-7
17 SGTC_2249 haloperidol 5.06 116.4 µM 7.11E-6 ergosterol depletion effects on membrane 60 2.14E-7
18 SGTC_2333 9017922 5.03 200.0 µM 7.88E-6 12 2.46E-7
19 SGTC_1679 4130-1276 5.02 6.7 µM 8.11E-6 Golgi 35 2.55E-7
20 SGTC_2396 5342950 4.98 42.8 µM 9.61E-6 RSC complex & mRNA processing 23 3.21E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.394 5.99E-125 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.217 5.93E-37 YBL067C UBP13 hom Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
0.215 1.78E-36 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.197 8.42E-31 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.173 6.53E-24 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.170 3.87E-23 YKR072C SIS2 hom Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
0.160 1.06E-20 YML112W CTK3 hom Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress
0.160 1.40E-20 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.157 5.29E-20 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.151 1.36E-18 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.151 1.35E-18 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.147 9.58E-18 YDR176W NGG1 hom Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
0.145 3.71E-17 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.140 4.05E-16 YNR012W URK1 hom Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
0.139 5.78E-16 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport