YDR292C / SRP101

Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR292C / SRP101

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.89|P-value:3.15E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:3.18|P-value:1.10E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.14|P-value:1.30E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.30|P-value:6.13E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.96|P-value:2.87E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.01|P-value:2.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.80|P-value:1.52E-15 ID:SGTC_317|Compound:4495-0002|FD-Score:2.84|P-value:4.89E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.53|P-value:2.15E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:2.75|P-value:6.91E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-2.81|P-value:5.65E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.66|P-value:2.39E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:3.72|P-value:7.82E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.71|P-value:8.20E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.06|P-value:1.95E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.72|P-value:7.99E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.00|P-value:1.64E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.31|P-value:2.81E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.76|P-value:6.84E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.27|P-value:7.46E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.52|P-value:7.43E-8 ID:SGTC_821|Compound:1114-0266|FD-Score:3.04|P-value:2.06E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.47|P-value:1.03E-10 ID:SGTC_828|Compound:2074-0507|FD-Score:2.85|P-value:4.58E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.72|P-value:8.01E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.17|P-value:6.19E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.88|P-value:3.17E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:4.32|P-value:2.63E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.16|P-value:1.24E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.96|P-value:2.07E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:2.92|P-value:3.45E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:2.74|P-value:7.08E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.51|P-value:2.28E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.77|P-value:6.50E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.53|P-value:2.13E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.99|P-value:2.54E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.97|P-value:2.92E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.79|P-value:6.07E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-2.79|P-value:6.14E-4 ID:SGTC_1686|Compound:st019653|FD-Score:-2.67|P-value:9.83E-4 ID:SGTC_1758|Compound:st042942|FD-Score:2.84|P-value:4.79E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.02|P-value:2.27E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.33|P-value:5.52E-5 ID:SGTC_1950|Compound:st077106|FD-Score:2.78|P-value:6.09E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-2.79|P-value:6.12E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.00|P-value:2.52E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.98|P-value:1.82E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.00|P-value:2.47E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.37|P-value:4.77E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.25|P-value:7.99E-5 ID:SGTC_2151|Compound:5563267|FD-Score:-2.92|P-value:3.59E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.17|P-value:1.16E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.79|P-value:6.20E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-2.80|P-value:5.80E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.36|P-value:2.08E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.15|P-value:1.24E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.00|P-value:2.43E-4 ID:SGTC_2486|Compound:5283202|FD-Score:2.66|P-value:9.83E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.82|P-value:5.22E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.06|P-value:1.91E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.05|P-value:1.92E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.00|P-value:2.46E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.27|P-value:7.59E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.88|P-value:3.20E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.59|P-value:1.52E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.05|P-value:1.96E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.60|P-value:1.47E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.81|P-value:4.82E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.16|P-value:1.20E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.82|P-value:4.58E-6 ID:SGTC_3132|Compound:9126706|FD-Score:5.62|P-value:3.23E-11 ID:SGTC_3140|Compound:9094243|FD-Score:-3.21|P-value:1.01E-4 ID:SGTC_3324|Compound:9138759|FD-Score:2.70|P-value:8.31E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.30|P-value:6.47E-5 ID:SGTC_3353|Compound:9151644|FD-Score:4.06|P-value:1.20E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:3.89|P-value:3.15E-6 ID:SGTC_79|Compound:0052-0007|FD-Score:3.18|P-value:1.10E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.14|P-value:1.30E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.30|P-value:6.13E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.96|P-value:2.87E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.01|P-value:2.37E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-6.80|P-value:1.52E-15 ID:SGTC_317|Compound:4495-0002|FD-Score:2.84|P-value:4.89E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:-3.53|P-value:2.15E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:2.75|P-value:6.91E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:-2.81|P-value:5.65E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.66|P-value:2.39E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:3.72|P-value:7.82E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.71|P-value:8.20E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.06|P-value:1.95E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-2.72|P-value:7.99E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.00|P-value:1.64E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.31|P-value:2.81E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:-2.76|P-value:6.84E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.27|P-value:7.46E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.52|P-value:7.43E-8 ID:SGTC_821|Compound:1114-0266|FD-Score:3.04|P-value:2.06E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:5.47|P-value:1.03E-10 ID:SGTC_828|Compound:2074-0507|FD-Score:2.85|P-value:4.58E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.72|P-value:8.01E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:4.17|P-value:6.19E-7 ID:SGTC_966|Compound:1300-0360|FD-Score:3.88|P-value:3.17E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:4.32|P-value:2.63E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.16|P-value:1.24E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.96|P-value:2.07E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:2.92|P-value:3.45E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:2.74|P-value:7.08E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.51|P-value:2.28E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.77|P-value:6.50E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.53|P-value:2.13E-5 ID:SGTC_1422|Compound:4031-0024|FD-Score:2.99|P-value:2.54E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-2.97|P-value:2.92E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-2.79|P-value:6.07E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-2.79|P-value:6.14E-4 ID:SGTC_1686|Compound:st019653|FD-Score:-2.67|P-value:9.83E-4 ID:SGTC_1758|Compound:st042942|FD-Score:2.84|P-value:4.79E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.02|P-value:2.27E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:3.33|P-value:5.52E-5 ID:SGTC_1950|Compound:st077106|FD-Score:2.78|P-value:6.09E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-2.79|P-value:6.12E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.00|P-value:2.52E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.98|P-value:1.82E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.00|P-value:2.47E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.37|P-value:4.77E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.25|P-value:7.99E-5 ID:SGTC_2151|Compound:5563267|FD-Score:-2.92|P-value:3.59E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.17|P-value:1.16E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-2.79|P-value:6.20E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-2.80|P-value:5.80E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-4.36|P-value:2.08E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.15|P-value:1.24E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.00|P-value:2.43E-4 ID:SGTC_2486|Compound:5283202|FD-Score:2.66|P-value:9.83E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.82|P-value:5.22E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.06|P-value:1.91E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.05|P-value:1.92E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.00|P-value:2.46E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.27|P-value:7.59E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.88|P-value:3.20E-6 ID:SGTC_2815|Compound:7968870|FD-Score:3.59|P-value:1.52E-5 ID:SGTC_2823|Compound:7987624|FD-Score:3.05|P-value:1.96E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-3.60|P-value:1.47E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.81|P-value:4.82E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.16|P-value:1.20E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.82|P-value:4.58E-6 ID:SGTC_3132|Compound:9126706|FD-Score:5.62|P-value:3.23E-11 ID:SGTC_3140|Compound:9094243|FD-Score:-3.21|P-value:1.01E-4 ID:SGTC_3324|Compound:9138759|FD-Score:2.70|P-value:8.31E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-3.30|P-value:6.47E-5 ID:SGTC_3353|Compound:9151644|FD-Score:4.06|P-value:1.20E-6

Top fitness defect scores for YDR292C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_365 0121-0052 5.66 13.6 µM 2.39E-11 mitochondrial response to ROS 1 7.51E-9 0.68
2 SGTC_3132 9126706 5.62 49.5 µM 3.23E-11 2 9.41E-9 0.58
3 SGTC_825 1988-2224 5.47 89.6 µM 1.03E-10 cell wall signaling 5 2.24E-8 0.43
4 SGTC_819 1013-0258 4.52 27.7 µM 7.43E-8 2 3.07E-6 0.33
5 SGTC_968 1309-0633 4.32 340.0 µM 2.63E-7 3 7.91E-6 0.19
6 SGTC_958 1222-0007 4.17 33.0 µM 6.19E-7 3 1.50E-5 0.17
7 SGTC_3353 9151644 4.06 39.3 µM 1.20E-6 2 2.47E-5 0.43
8 SGTC_562 3772-2733 4.00 112.0 µM 1.64E-6 ERG2 12 3.12E-5 0.37
9 SGTC_1973 st070275 3.98 50.2 µM 1.82E-6 1 3.38E-5 0.45
10 SGTC_1055 3448-0672 3.96 86.0 µM 2.07E-6 11 3.72E-5 0.14
11 SGTC_16 erodoxin 3.89 22.8 µM 3.15E-6 unfolded protein response 32 5.11E-5 0.04
12 SGTC_966 1300-0360 3.88 30.2 µM 3.17E-6 heme requiring 19 5.13E-5 0.07
13 SGTC_2812 7970281 3.88 58.4 µM 3.20E-6 9 5.16E-5 0.05
14 SGTC_2957 9076800 3.82 11.5 µM 4.58E-6 4 6.76E-5 0.02
15 SGTC_2934 9036370 3.81 36.9 µM 4.82E-6 6 7.03E-5 0.09
16 SGTC_367 0335-0881 3.72 7.1 µM 7.82E-6 ubiquinone biosynthesis & proteasome 27 1.01E-4 0.13
17 SGTC_369 0957-0393 3.71 4.5 µM 8.20E-6 cell wall signaling 12 1.05E-4 0.36
18 SGTC_2815 7968870 3.59 71.4 µM 1.52E-5 8 1.67E-4 0.08
19 SGTC_1280 0880-0253 3.51 10.1 µM 2.28E-5 4 2.26E-4 0.23
20 SGTC_1880 MG-132 3.33 525.0 µM 5.52E-5 25 4.40E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.99E-17 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.141 1.85E-16 YDL120W YFH1 het Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.138 9.26E-16 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.127 1.87E-13 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.124 5.10E-13 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.122 1.41E-12 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.121 2.10E-12 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.118 7.52E-12 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.111 1.18E-10 YIL147C SLN1 het Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
0.111 1.23E-10 YEL042W GDA1 hom Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
0.108 3.52E-10 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.102 3.67E-9 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.101 4.01E-9 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.101 4.66E-9 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.100 5.74E-9 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain