YDR293C / SSD1

Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR293C / SSD1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:5.26|P-value:6.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.35|P-value:5.03E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:6.35|P-value:5.06E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:7.31|P-value:3.51E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:5.70|P-value:2.47E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.67|P-value:4.61E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:7.47|P-value:2.23E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:6.59|P-value:2.68E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:-5.50|P-value:2.19E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-4.83|P-value:9.66E-4 ID:SGTC_397|Compound:arbidol|FD-Score:5.74|P-value:2.24E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.42|P-value:4.68E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:7.22|P-value:4.64E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.52|P-value:3.73E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:6.49|P-value:3.46E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:5.92|P-value:1.46E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:6.16|P-value:8.15E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:5.19|P-value:7.83E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:5.52|P-value:3.74E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:8.42|P-value:1.08E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:5.56|P-value:3.43E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:5.55|P-value:3.53E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.86|P-value:1.70E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:5.86|P-value:1.70E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:6.14|P-value:8.57E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:7.00|P-value:8.65E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:9.09|P-value:1.06E-8 ID:SGTC_928|Compound:2764-0428|FD-Score:9.16|P-value:8.31E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:6.97|P-value:9.54E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:6.80|P-value:1.52E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:6.47|P-value:3.63E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:8.69|P-value:4.34E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:-12.40|P-value:3.10E-15 ID:SGTC_1232|Compound:0279-0259|FD-Score:-5.66|P-value:1.49E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-5.44|P-value:2.53E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:6.05|P-value:1.07E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:7.22|P-value:4.67E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:9.94|P-value:4.30E-10 ID:SGTC_1494|Compound:4358-1428|FD-Score:12.60|P-value:3.08E-15 ID:SGTC_1627|Compound:st003713|FD-Score:8.38|P-value:1.23E-7 ID:SGTC_1665|Compound:st014639|FD-Score:6.53|P-value:3.14E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.08|P-value:9.71E-4 ID:SGTC_1714|Compound:st033236|FD-Score:5.27|P-value:6.47E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.10|P-value:9.30E-4 ID:SGTC_1778|Compound:st046819|FD-Score:7.19|P-value:5.01E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-5.02|P-value:6.45E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.35|P-value:3.07E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.77|P-value:2.08E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:7.06|P-value:7.40E-6 ID:SGTC_1909|Compound:st060837|FD-Score:5.90|P-value:1.55E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-4.91|P-value:8.31E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.32|P-value:5.87E-4 ID:SGTC_2163|Compound:5671233|FD-Score:8.11|P-value:3.00E-7 ID:SGTC_2165|Compound:5727197|FD-Score:6.36|P-value:4.91E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.70|P-value:2.49E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-5.33|P-value:3.22E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.81|P-value:7.90E-7 ID:SGTC_2323|Compound:6148992|FD-Score:5.38|P-value:5.09E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.37|P-value:5.25E-4 ID:SGTC_2367|Compound:9070478|FD-Score:11.50|P-value:4.85E-13 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:8.36|P-value:1.31E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.12|P-value:9.09E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:7.79|P-value:8.39E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:9.45|P-value:2.85E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-5.96|P-value:7.09E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:6.64|P-value:2.34E-5 ID:SGTC_2716|Compound:st080858|FD-Score:5.11|P-value:9.29E-4 ID:SGTC_2717|Compound:st081029|FD-Score:5.68|P-value:2.59E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.09|P-value:9.54E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-5.56|P-value:1.91E-4 ID:SGTC_2839|Compound:9003951|FD-Score:6.05|P-value:1.07E-4 ID:SGTC_2845|Compound:9003024|FD-Score:5.22|P-value:7.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.15|P-value:5.74E-6 ID:SGTC_2953|Compound:9074162|FD-Score:7.23|P-value:4.44E-6 ID:SGTC_3020|Compound:9089140|FD-Score:6.70|P-value:2.01E-5 ID:SGTC_3025|Compound:9087895|FD-Score:14.00|P-value:1.90E-18 ID:SGTC_3038|Compound:9091290|FD-Score:5.36|P-value:5.32E-4 ID:SGTC_3065|Compound:9113888|FD-Score:9.15|P-value:8.55E-9 ID:SGTC_3074|Compound:9116018|FD-Score:12.00|P-value:7.03E-14 ID:SGTC_3211|Compound:9128781|FD-Score:9.06|P-value:1.17E-8 ID:SGTC_3266|Compound:9136860|FD-Score:7.07|P-value:7.08E-6 ID:SGTC_3285|Compound:9112818|FD-Score:9.15|P-value:8.47E-9 ID:SGTC_3288|Compound:9119690|FD-Score:7.50|P-value:2.00E-6 ID:SGTC_3311|Compound:9131146|FD-Score:8.28|P-value:1.73E-7 ID:SGTC_3322|Compound:9139058|FD-Score:7.72|P-value:1.02E-6 ID:SGTC_3350|Compound:9150499|FD-Score:8.26|P-value:1.84E-7 ID:SGTC_3351|Compound:9150312|FD-Score:5.79|P-value:2.01E-4 ID:SGTC_3356|Compound:9151811|FD-Score:5.55|P-value:3.53E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.26|P-value:6.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.35|P-value:5.03E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:6.35|P-value:5.06E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:7.31|P-value:3.51E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:5.70|P-value:2.47E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.67|P-value:4.61E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:7.47|P-value:2.23E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:6.59|P-value:2.68E-5 ID:SGTC_280|Compound:3448-3607|FD-Score:-5.50|P-value:2.19E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-4.83|P-value:9.66E-4 ID:SGTC_397|Compound:arbidol|FD-Score:5.74|P-value:2.24E-4 ID:SGTC_483|Compound:fpl-64176|FD-Score:5.42|P-value:4.68E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:7.22|P-value:4.64E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:5.52|P-value:3.73E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:6.49|P-value:3.46E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:5.92|P-value:1.46E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:6.16|P-value:8.15E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:5.19|P-value:7.83E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:5.52|P-value:3.74E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:8.42|P-value:1.08E-7 ID:SGTC_679|Compound:0422-0091|FD-Score:5.56|P-value:3.43E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:5.55|P-value:3.53E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:5.86|P-value:1.70E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:5.86|P-value:1.70E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:6.14|P-value:8.57E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:7.00|P-value:8.65E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:9.09|P-value:1.06E-8 ID:SGTC_928|Compound:2764-0428|FD-Score:9.16|P-value:8.31E-9 ID:SGTC_951|Compound:1171-0579|FD-Score:6.97|P-value:9.54E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:6.80|P-value:1.52E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:6.47|P-value:3.63E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:8.69|P-value:4.34E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:-12.40|P-value:3.10E-15 ID:SGTC_1232|Compound:0279-0259|FD-Score:-5.66|P-value:1.49E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-5.44|P-value:2.53E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:6.05|P-value:1.07E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:7.22|P-value:4.67E-6 ID:SGTC_1464|Compound:k208-0027|FD-Score:9.94|P-value:4.30E-10 ID:SGTC_1494|Compound:4358-1428|FD-Score:12.60|P-value:3.08E-15 ID:SGTC_1627|Compound:st003713|FD-Score:8.38|P-value:1.23E-7 ID:SGTC_1665|Compound:st014639|FD-Score:6.53|P-value:3.14E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.08|P-value:9.71E-4 ID:SGTC_1714|Compound:st033236|FD-Score:5.27|P-value:6.47E-4 ID:SGTC_1760|Compound:st045453|FD-Score:5.10|P-value:9.30E-4 ID:SGTC_1778|Compound:st046819|FD-Score:7.19|P-value:5.01E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-5.02|P-value:6.45E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.35|P-value:3.07E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.77|P-value:2.08E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:7.06|P-value:7.40E-6 ID:SGTC_1909|Compound:st060837|FD-Score:5.90|P-value:1.55E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-4.91|P-value:8.31E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.32|P-value:5.87E-4 ID:SGTC_2163|Compound:5671233|FD-Score:8.11|P-value:3.00E-7 ID:SGTC_2165|Compound:5727197|FD-Score:6.36|P-value:4.91E-5 ID:SGTC_2286|Compound:7945697|FD-Score:5.70|P-value:2.49E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-5.33|P-value:3.22E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.81|P-value:7.90E-7 ID:SGTC_2323|Compound:6148992|FD-Score:5.38|P-value:5.09E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.37|P-value:5.25E-4 ID:SGTC_2367|Compound:9070478|FD-Score:11.50|P-value:4.85E-13 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:8.36|P-value:1.31E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.12|P-value:9.09E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:7.79|P-value:8.39E-7 ID:SGTC_2533|Compound:agelasine|FD-Score:9.45|P-value:2.85E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-5.96|P-value:7.09E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:6.64|P-value:2.34E-5 ID:SGTC_2716|Compound:st080858|FD-Score:5.11|P-value:9.29E-4 ID:SGTC_2717|Compound:st081029|FD-Score:5.68|P-value:2.59E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.09|P-value:9.54E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-5.56|P-value:1.91E-4 ID:SGTC_2839|Compound:9003951|FD-Score:6.05|P-value:1.07E-4 ID:SGTC_2845|Compound:9003024|FD-Score:5.22|P-value:7.22E-4 ID:SGTC_2912|Compound:7964298|FD-Score:7.15|P-value:5.74E-6 ID:SGTC_2953|Compound:9074162|FD-Score:7.23|P-value:4.44E-6 ID:SGTC_3020|Compound:9089140|FD-Score:6.70|P-value:2.01E-5 ID:SGTC_3025|Compound:9087895|FD-Score:14.00|P-value:1.90E-18 ID:SGTC_3038|Compound:9091290|FD-Score:5.36|P-value:5.32E-4 ID:SGTC_3065|Compound:9113888|FD-Score:9.15|P-value:8.55E-9 ID:SGTC_3074|Compound:9116018|FD-Score:12.00|P-value:7.03E-14 ID:SGTC_3211|Compound:9128781|FD-Score:9.06|P-value:1.17E-8 ID:SGTC_3266|Compound:9136860|FD-Score:7.07|P-value:7.08E-6 ID:SGTC_3285|Compound:9112818|FD-Score:9.15|P-value:8.47E-9 ID:SGTC_3288|Compound:9119690|FD-Score:7.50|P-value:2.00E-6 ID:SGTC_3311|Compound:9131146|FD-Score:8.28|P-value:1.73E-7 ID:SGTC_3322|Compound:9139058|FD-Score:7.72|P-value:1.02E-6 ID:SGTC_3350|Compound:9150499|FD-Score:8.26|P-value:1.84E-7 ID:SGTC_3351|Compound:9150312|FD-Score:5.79|P-value:2.01E-4 ID:SGTC_3356|Compound:9151811|FD-Score:5.55|P-value:3.53E-4

Top fitness defect scores for YDR293C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3025 9087895 14.00 49.5 µM 1.90E-18 PDR1 2 5.82E-45
2 SGTC_1494 4358-1428 12.60 177.0 µM 3.08E-15 2 9.69E-37
3 SGTC_3074 9116018 12.00 49.5 µM 7.03E-14 RNA processing & uracil transport 1 2.91E-33
4 SGTC_2367 9070478 11.50 135.4 µM 4.85E-13 cell wall 1 4.08E-31
5 SGTC_1464 k208-0027 9.94 110.0 µM 4.30E-10 2 1.40E-23
6 SGTC_2533 agelasine 9.45 13.7 µM 2.85E-9 ERG2 5 1.75E-21
7 SGTC_928 2764-0428 9.16 58.7 µM 8.31E-9 cell wall 5 2.69E-20
8 SGTC_3285 9112818 9.15 20.9 µM 8.47E-9 cell wall 3 2.82E-20
9 SGTC_3065 9113888 9.15 49.5 µM 8.55E-9 1 2.89E-20
10 SGTC_883 0850-0245 9.09 24.6 µM 1.06E-8 cell wall 4 5.00E-20
11 SGTC_3211 9128781 9.06 49.5 µM 1.17E-8 9 6.42E-20
12 SGTC_1202 1988-0068 8.69 29.6 µM 4.34E-8 RNA processing & uracil transport 3 1.82E-18
13 SGTC_221 trifluoperazine 8.67 10.3 µM 4.61E-8 NEO1-PIK1 76 2.12E-18
14 SGTC_666 0272-0154 8.42 136.0 µM 1.08E-7 cell wall 8 1.85E-17
15 SGTC_1627 st003713 8.38 25.6 µM 1.23E-7 calcium & mitochondrial duress 12 2.58E-17
16 SGTC_2454 5-benzylidenerhodanine 8.36 10.4 µM 1.31E-7 TRP & mitochondrial translation 7 3.05E-17
17 SGTC_3311 9131146 8.28 2.9 µM 1.73E-7 cell wall 29 6.17E-17
18 SGTC_3350 9150499 8.26 3.6 µM 1.84E-7 cell wall 6 7.23E-17
19 SGTC_2163 5671233 8.11 125.0 µM 3.00E-7 3 2.50E-16
20 SGTC_2322 7413319 7.81 38.2 µM 7.90E-7 ERAD & cell cycle 35 2.92E-15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 2.65E-76 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.268 8.25E-56 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.258 1.13E-51 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.220 7.62E-38 YER133W GLC7 het Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
0.198 7.24E-31 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.197 1.63E-30 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.193 1.83E-29 YKL037W AIM26 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
0.192 4.91E-29 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.189 2.77E-28 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
0.188 7.74E-28 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.186 2.59E-27 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.185 4.44E-27 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.176 1.78E-24 YDR253C MET32 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
0.173 6.71E-24 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.172 1.83E-23 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization