HIPHOP chemogenomics database

YDR296W / MHR1

Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR296W / MHR1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR296W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	13.60	5.3 µM	3.25E-34		127	1.33E-42
2	SGTC_173	1273-0061	12.70	2.7 µM	4.92E-30	mitochondrial stress	18	2.47E-37
3	SGTC_310	1273-0058	7.24	1.1 µM	5.23E-11	mitochondrial stress	110	2.17E-13
4	SGTC_2995	9067767	7.06	71.4 µM	1.56E-10		1	8.57E-13
5	SGTC_2250	alverine citrate	6.35	130.0 µM	7.48E-9		45	1.09E-10
6	SGTC_275	trichlorophene	5.66	5.7 µM	2.24E-7	mitochondrial stress	131	7.74E-9
7	SGTC_1922	5578187	4.94	25.0 µM	5.22E-6	TRP & mitochondrial translation	10	3.95E-7
8	SGTC_2087	5276107	4.65	200.0 µM	1.67E-5		9	1.69E-6
9	SGTC_933	2914-0560	4.48	114.0 µM	3.18E-5		18	3.76E-6
10	SGTC_2232	chlorophetanol	4.40	41.5 µM	4.31E-5	TRP & mitochondrial translation	103	5.51E-6
11	SGTC_28	pentachloropyridine N-oxide	4.29	1.6 µM	6.39E-5	TSC3-RPN4	58	8.98E-6
12	SGTC_2094	5332512	4.29	191.7 µM	6.42E-5		18	9.04E-6
13	SGTC_965	1291-5240	4.19	308.0 µM	8.98E-5		27	1.37E-5
14	SGTC_876	0720-0963	4.17	56.8 µM	9.87E-5		10	1.54E-5
15	SGTC_1627	st003713	4.07	25.6 µM	1.40E-4	calcium & mitochondrial duress	69	2.38E-5
16	SGTC_1883	5-benzylidenerhodanine	4.06	20.0 µM	1.45E-4	TRP & mitochondrial translation	66	2.49E-5
17	SGTC_1622	st003707	3.96	19.4 µM	2.01E-4	calcium & mitochondrial duress	37	3.74E-5
18	SGTC_2533	agelasine	3.94	13.7 µM	2.19E-4	ERG2	49	4.16E-5
19	SGTC_967	1306-0166	3.93	352.0 µM	2.23E-4		36	4.25E-5
20	SGTC_2669	eugenol	3.89	100.0 µM	2.52E-4		12	4.94E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.488	9.74E-201	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.470	1.25E-183	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.469	3.68E-183	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.463	1.14E-177	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.456	1.54E-171	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.455	2.92E-171	YKL170W	MRPL38	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.451	1.95E-167	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.449	1.51E-166	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.440	7.72E-159	YOL095C	HMI1	hom	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.437	2.86E-156	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.433	3.01E-153	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.432	1.87E-152	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.430	6.41E-151	YDR268W	MSW1	hom	Mitochondrial tryptophanyl-tRNA synthetase
0.426	8.22E-148	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.422	2.97E-145	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit