YDR298C / ATP5

Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR298C / ATP5

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.98|P-value:1.54E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.65|P-value:3.13E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.98|P-value:1.54E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.11|P-value:5.91E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.55|P-value:1.08E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:8.14|P-value:1.21E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:13.70|P-value:3.97E-38 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.65|P-value:6.15E-8 ID:SGTC_283|Compound:0987-0079|FD-Score:3.68|P-value:2.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.22|P-value:2.94E-18 ID:SGTC_625|Compound:k213-0058|FD-Score:3.62|P-value:3.49E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.35|P-value:8.39E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.34|P-value:2.84E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.52|P-value:4.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.21|P-value:3.98E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.45|P-value:6.05E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.32|P-value:9.55E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.37|P-value:2.56E-12 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.03|P-value:1.22E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.60|P-value:3.86E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.14|P-value:7.25E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.88|P-value:1.36E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.43|P-value:6.86E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.43|P-value:6.45E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:7.61|P-value:5.13E-13 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.46|P-value:5.88E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.77|P-value:2.14E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.75|P-value:2.34E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.49|P-value:5.52E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.07|P-value:1.01E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.43|P-value:6.72E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.39|P-value:7.50E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.63|P-value:6.71E-8 ID:SGTC_1623|Compound:st003709|FD-Score:5.59|P-value:8.11E-8 ID:SGTC_1678|Compound:st019265|FD-Score:-3.74|P-value:2.36E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.11|P-value:6.10E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.77|P-value:2.07E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.34|P-value:3.07E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.52|P-value:1.22E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.38|P-value:7.71E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.53|P-value:4.69E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.97|P-value:1.05E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.24|P-value:2.71E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-3.93|P-value:1.23E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.69|P-value:5.80E-6 ID:SGTC_1820|Compound:st053765|FD-Score:-3.79|P-value:2.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.66|P-value:2.95E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.90|P-value:2.32E-6 ID:SGTC_1982|Compound:st072467|FD-Score:-3.37|P-value:8.36E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.79|P-value:1.90E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-6.33|P-value:1.67E-9 ID:SGTC_2136|Compound:5328288|FD-Score:-7.67|P-value:3.79E-13 ID:SGTC_2157|Compound:5649910|FD-Score:-3.77|P-value:2.16E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.08|P-value:6.68E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.98|P-value:1.07E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.86|P-value:1.49E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.12|P-value:5.54E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.32|P-value:9.59E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.60|P-value:3.71E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.54|P-value:4.71E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.46|P-value:1.45E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.92|P-value:2.05E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.68|P-value:6.07E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.04|P-value:8.11E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:7.03|P-value:2.26E-11 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.65|P-value:6.94E-6 ID:SGTC_2671|Compound:danthron|FD-Score:-4.55|P-value:1.06E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.45|P-value:6.32E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.85|P-value:1.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.09|P-value:6.29E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.57|P-value:4.18E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.32|P-value:2.70E-5 ID:SGTC_2890|Compound:9046729|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.13|P-value:1.32E-11 ID:SGTC_2993|Compound:9054257|FD-Score:-3.37|P-value:8.32E-4 ID:SGTC_3172|Compound:9105863|FD-Score:-3.34|P-value:9.23E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.98|P-value:1.54E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.65|P-value:3.13E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.98|P-value:1.54E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.11|P-value:5.91E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.55|P-value:1.08E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:8.14|P-value:1.21E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:13.70|P-value:3.97E-38 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.65|P-value:6.15E-8 ID:SGTC_283|Compound:0987-0079|FD-Score:3.68|P-value:2.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.22|P-value:2.94E-18 ID:SGTC_625|Compound:k213-0058|FD-Score:3.62|P-value:3.49E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.35|P-value:8.39E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.34|P-value:2.84E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.52|P-value:4.81E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.21|P-value:3.98E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.45|P-value:6.05E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.32|P-value:9.55E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:7.37|P-value:2.56E-12 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.03|P-value:1.22E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.60|P-value:3.86E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.14|P-value:7.25E-7 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.88|P-value:1.36E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.43|P-value:6.86E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.43|P-value:6.45E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:7.61|P-value:5.13E-13 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.46|P-value:5.88E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.77|P-value:2.14E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:-3.75|P-value:2.34E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.49|P-value:5.52E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.07|P-value:1.01E-6 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.43|P-value:6.72E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.39|P-value:7.50E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.63|P-value:6.71E-8 ID:SGTC_1623|Compound:st003709|FD-Score:5.59|P-value:8.11E-8 ID:SGTC_1678|Compound:st019265|FD-Score:-3.74|P-value:2.36E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.11|P-value:6.10E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.77|P-value:2.07E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.34|P-value:3.07E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.52|P-value:1.22E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.38|P-value:7.71E-4 ID:SGTC_1742|Compound:st038235|FD-Score:6.53|P-value:4.69E-10 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.97|P-value:1.05E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.24|P-value:2.71E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-3.93|P-value:1.23E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.69|P-value:5.80E-6 ID:SGTC_1820|Compound:st053765|FD-Score:-3.79|P-value:2.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.66|P-value:2.95E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.90|P-value:2.32E-6 ID:SGTC_1982|Compound:st072467|FD-Score:-3.37|P-value:8.36E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.79|P-value:1.90E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-6.33|P-value:1.67E-9 ID:SGTC_2136|Compound:5328288|FD-Score:-7.67|P-value:3.79E-13 ID:SGTC_2157|Compound:5649910|FD-Score:-3.77|P-value:2.16E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.08|P-value:6.68E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.98|P-value:1.07E-8 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.86|P-value:1.49E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.12|P-value:5.54E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.32|P-value:9.59E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.64|P-value:3.17E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.60|P-value:3.71E-4 ID:SGTC_2446|Compound:5162541|FD-Score:-3.54|P-value:4.71E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.46|P-value:1.45E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.92|P-value:2.05E-6 ID:SGTC_2618|Compound:avocadyne|FD-Score:-4.68|P-value:6.07E-6 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:-4.04|P-value:8.11E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:7.03|P-value:2.26E-11 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.65|P-value:6.94E-6 ID:SGTC_2671|Compound:danthron|FD-Score:-4.55|P-value:1.06E-5 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.45|P-value:6.32E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.85|P-value:1.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.09|P-value:6.29E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-6.57|P-value:4.18E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.32|P-value:2.70E-5 ID:SGTC_2890|Compound:9046729|FD-Score:3.42|P-value:6.70E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.13|P-value:1.32E-11 ID:SGTC_2993|Compound:9054257|FD-Score:-3.37|P-value:8.32E-4 ID:SGTC_3172|Compound:9105863|FD-Score:-3.34|P-value:9.23E-4

Top fitness defect scores for YDR298C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.70 5.3 µM 3.97E-38 124 3.25E-43
2 SGTC_310 1273-0058 9.22 1.1 µM 2.94E-18 mitochondrial stress 58 1.47E-20
3 SGTC_173 1273-0061 8.14 2.7 µM 1.21E-14 mitochondrial stress 64 1.94E-16
4 SGTC_1319 1306-0155 7.61 43.7 µM 5.13E-13 2 1.38E-14
5 SGTC_1036 k216-0215 7.37 33.5 µM 2.56E-12 mitochondrial response to ROS 7 8.59E-14
6 SGTC_2627 acetyl isogambogic acid 7.03 100.0 µM 2.26E-11 TSC3-RPN4 9 1.03E-12
7 SGTC_1742 st038235 6.53 28.9 µM 4.69E-10 mitochondrial stress 34 3.23E-11
8 SGTC_2232 chlorophetanol 5.98 41.5 µM 1.07E-8 TRP & mitochondrial translation 42 1.13E-9
9 SGTC_275 trichlorophene 5.65 5.7 µM 6.15E-8 mitochondrial stress 132 8.26E-9
10 SGTC_1622 st003707 5.63 19.4 µM 6.71E-8 calcium & mitochondrial duress 10 9.10E-9
11 SGTC_1623 st003709 5.59 20.3 µM 8.11E-8 calcium & mitochondrial duress 15 1.13E-8
12 SGTC_691 1548-0686 5.34 185.0 µM 2.84E-7 7 4.68E-8
13 SGTC_1188 1403-0014 5.14 4.6 µM 7.25E-7 mitochondrial stress 26 1.36E-7
14 SGTC_1514 1189-1591 5.07 158.0 µM 1.01E-6 18 1.98E-7
15 SGTC_1037 k284-1091 5.03 78.7 µM 1.22E-6 4 2.45E-7
16 SGTC_63 0099-0242 4.98 26.7 µM 1.54E-6 mitochondrial stress 57 3.19E-7
17 SGTC_10 0279-0212 4.98 42.6 µM 1.54E-6 TRP & mitochondrial translation 63 3.20E-7
18 SGTC_2526 patulin 4.92 37.6 µM 2.05E-6 49 4.42E-7
19 SGTC_2488 5268135 4.46 45.7 µM 1.45E-5 36 4.06E-6
20 SGTC_908 3448-7491 4.21 47.7 µM 3.98E-5 mitochondrial stress 107 1.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.508 2.00E-219 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.495 8.92E-207 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.488 1.43E-199 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.481 8.31E-194 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.471 8.89E-185 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.467 1.42E-181 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.457 1.47E-172 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.449 1.49E-166 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.446 2.73E-163 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.446 1.58E-163 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.445 2.96E-163 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.440 1.19E-158 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.440 1.60E-158 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.436 1.09E-155 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.435 5.19E-155 YNR037C RSM19 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein