YDR302W / GPI11

ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR302W / GPI11

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.98|P-value:3.48E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.42|P-value:8.13E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.66|P-value:4.88E-9 ID:SGTC_162|Compound:k030-0015|FD-Score:4.47|P-value:6.97E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.93|P-value:4.03E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.96|P-value:3.16E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.08|P-value:2.14E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-5.81|P-value:2.90E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.18|P-value:1.84E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.05|P-value:2.40E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.58|P-value:4.77E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:8.29|P-value:7.05E-13 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.08|P-value:8.17E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:3.84|P-value:5.44E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.03|P-value:2.99E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.02|P-value:3.05E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.82|P-value:5.67E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.62|P-value:8.80E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:5.50|P-value:1.37E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.69|P-value:5.87E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.71|P-value:2.98E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:-4.61|P-value:3.55E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.44|P-value:7.77E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.72|P-value:6.58E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-6.70|P-value:4.18E-9 ID:SGTC_2241|Compound:6772625|FD-Score:7.84|P-value:1.03E-11 ID:SGTC_2394|Compound:5221648|FD-Score:6.48|P-value:1.54E-8 ID:SGTC_2425|Compound:5628681|FD-Score:4.45|P-value:7.36E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.77|P-value:2.34E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.46|P-value:7.22E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.81|P-value:5.94E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.82|P-value:5.66E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.16|P-value:1.67E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-11.20|P-value:4.23E-22 ID:SGTC_2831|Compound:7999036|FD-Score:5.95|P-value:1.89E-7 ID:SGTC_2833|Compound:9001315|FD-Score:6.44|P-value:1.87E-8 ID:SGTC_2894|Compound:9048625|FD-Score:4.96|P-value:1.14E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.88|P-value:4.73E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.81|P-value:2.08E-5 ID:SGTC_3132|Compound:9126706|FD-Score:4.66|P-value:3.58E-5 ID:SGTC_3215|Compound:9129942|FD-Score:4.84|P-value:1.81E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.44|P-value:7.72E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.98|P-value:3.48E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:4.42|P-value:8.13E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-6.66|P-value:4.88E-9 ID:SGTC_162|Compound:k030-0015|FD-Score:4.47|P-value:6.97E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.93|P-value:4.03E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-3.96|P-value:3.16E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.08|P-value:2.14E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-5.81|P-value:2.90E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.18|P-value:1.84E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-4.05|P-value:2.40E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.58|P-value:4.77E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:8.29|P-value:7.05E-13 ID:SGTC_778|Compound:3456-2434|FD-Score:-6.08|P-value:8.17E-8 ID:SGTC_795|Compound:0685-0265|FD-Score:3.84|P-value:5.44E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:4.03|P-value:2.99E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:4.02|P-value:3.05E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.82|P-value:5.67E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.62|P-value:8.80E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:5.50|P-value:1.37E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.69|P-value:5.87E-7 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.71|P-value:2.98E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:-4.61|P-value:3.55E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.44|P-value:7.77E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-3.72|P-value:6.58E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-6.70|P-value:4.18E-9 ID:SGTC_2241|Compound:6772625|FD-Score:7.84|P-value:1.03E-11 ID:SGTC_2394|Compound:5221648|FD-Score:6.48|P-value:1.54E-8 ID:SGTC_2425|Compound:5628681|FD-Score:4.45|P-value:7.36E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.77|P-value:2.34E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.46|P-value:7.22E-5 ID:SGTC_2712|Compound:st079126|FD-Score:3.81|P-value:5.94E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.82|P-value:5.66E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-4.16|P-value:1.67E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-11.20|P-value:4.23E-22 ID:SGTC_2831|Compound:7999036|FD-Score:5.95|P-value:1.89E-7 ID:SGTC_2833|Compound:9001315|FD-Score:6.44|P-value:1.87E-8 ID:SGTC_2894|Compound:9048625|FD-Score:4.96|P-value:1.14E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.88|P-value:4.73E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.81|P-value:2.08E-5 ID:SGTC_3132|Compound:9126706|FD-Score:4.66|P-value:3.58E-5 ID:SGTC_3215|Compound:9129942|FD-Score:4.84|P-value:1.81E-5 ID:SGTC_3217|Compound:9129673|FD-Score:4.44|P-value:7.72E-5

Top fitness defect scores for YDR302W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_513 4245-1575 8.29 41.7 µM 7.05E-13 unfolded protein response 4 5.81E-17 0.05
2 SGTC_2241 6772625 7.84 37.8 µM 1.03E-11 2 2.21E-15 1.66
3 SGTC_2394 5221648 6.48 200.0 µM 1.54E-8 1 4.47E-11 1.74
4 SGTC_2833 9001315 6.44 45.5 µM 1.87E-8 amide catabolism 3 5.85E-11 0.91
5 SGTC_2831 7999036 5.95 19.5 µM 1.89E-7 1 1.34E-9 1.55
6 SGTC_1047 2043-3044 5.69 82.0 µM 5.87E-7 1 6.21E-9 0.97
7 SGTC_947 3447-0010 5.50 211.0 µM 1.37E-6 2 1.95E-8 1.50
8 SGTC_2894 9048625 4.96 32.5 µM 1.14E-5 3 3.44E-7 0.05
9 SGTC_3215 9129942 4.84 49.5 µM 1.81E-5 2 6.38E-7 0.57
10 SGTC_3126 9127922 4.81 49.5 µM 2.08E-5 fatty acid desaturase (OLE1) 18 7.70E-7 0.02
11 SGTC_2596 sinensetin 4.77 100.0 µM 2.34E-5 1 9.04E-7 0.45
12 SGTC_1287 0971-0001 4.71 34.6 µM 2.98E-5 sphingolipid biosynthesis & PDR1 4 1.25E-6 1.00
13 SGTC_3132 9126706 4.66 49.5 µM 3.58E-5 5 1.61E-6 0.05
14 SGTC_430 0958-0115 4.58 16.4 µM 4.77E-5 5 2.37E-6 0.10
15 SGTC_162 k030-0015 4.47 37.8 µM 6.97E-5 iron homeostasis 4 3.94E-6 0.37
16 SGTC_2601 securinine 4.46 100.0 µM 7.22E-5 12 4.14E-6 0.00
17 SGTC_2425 5628681 4.45 7.8 µM 7.36E-5 3 4.25E-6 0.35
18 SGTC_3217 9129673 4.44 49.5 µM 7.72E-5 6 4.53E-6 0.21
19 SGTC_1575 cyproterone acetate 4.44 48.0 µM 7.77E-5 4 4.57E-6 0.14
20 SGTC_78 0336-0123 4.42 156.8 µM 8.13E-5 6 4.85E-6 0.57

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.85E-14 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.119 4.34E-12 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.117 1.06E-11 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.106 7.42E-10 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.104 1.72E-9 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.103 2.66E-9 YPR086W SUA7 het Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
0.100 5.65E-9 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.099 7.70E-9 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.099 7.82E-9 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.099 9.03E-9 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.099 9.73E-9 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.095 3.71E-8 YLL031C GPI13 het ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
0.094 4.73E-8 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.094 5.17E-8 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.094 5.37E-8 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family