YDR305C / HNT2

Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR305C / HNT2

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.79|P-value:2.09E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.88|P-value:1.33E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.03|P-value:5.23E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.54|P-value:6.51E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.05|P-value:4.91E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.07|P-value:5.31E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:-4.52|P-value:5.16E-7 ID:SGTC_539|Compound:4859-0462|FD-Score:5.51|P-value:1.30E-9 ID:SGTC_705|Compound:1124-0212|FD-Score:3.27|P-value:2.06E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.03|P-value:5.23E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.28|P-value:2.00E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.54|P-value:6.47E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:6.01|P-value:3.96E-11 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.63|P-value:4.41E-5 ID:SGTC_918|Compound:glabranin|FD-Score:-2.94|P-value:7.43E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.20|P-value:2.75E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.47|P-value:8.74E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.87|P-value:9.42E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:5.50|P-value:1.40E-9 ID:SGTC_1304|Compound:1165-0502|FD-Score:-2.87|P-value:9.80E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.59|P-value:3.39E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:-4.31|P-value:1.60E-6 ID:SGTC_1523|Compound:st012844|FD-Score:-3.38|P-value:1.31E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.35|P-value:1.48E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:5.45|P-value:1.88E-9 ID:SGTC_1838|Compound:st055369|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.87|P-value:1.44E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.72|P-value:2.96E-5 ID:SGTC_1897|Compound:st060201|FD-Score:-3.49|P-value:8.15E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.02|P-value:6.95E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.64|P-value:4.15E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.07|P-value:4.46E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.91|P-value:8.26E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.81|P-value:1.90E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.89|P-value:9.00E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.24|P-value:2.32E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.32|P-value:1.66E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.64|P-value:2.70E-7 ID:SGTC_2693|Compound:st077581|FD-Score:3.45|P-value:9.67E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.51|P-value:7.33E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.80|P-value:1.99E-5 ID:SGTC_3005|Compound:9076496|FD-Score:-3.53|P-value:6.93E-5 ID:SGTC_3009|Compound:9080819|FD-Score:2.92|P-value:8.02E-4 ID:SGTC_3256|Compound:9138902|FD-Score:-2.93|P-value:7.76E-4 ID:SGTC_3330|Compound:9141424|FD-Score:2.88|P-value:9.23E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.37|P-value:1.32E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.79|P-value:2.09E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.88|P-value:1.33E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.03|P-value:5.23E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.54|P-value:6.51E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.05|P-value:4.91E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.02|P-value:5.53E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:4.07|P-value:5.31E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:-4.52|P-value:5.16E-7 ID:SGTC_539|Compound:4859-0462|FD-Score:5.51|P-value:1.30E-9 ID:SGTC_705|Compound:1124-0212|FD-Score:3.27|P-value:2.06E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.03|P-value:5.23E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.28|P-value:2.00E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.54|P-value:6.47E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:6.01|P-value:3.96E-11 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.63|P-value:4.41E-5 ID:SGTC_918|Compound:glabranin|FD-Score:-2.94|P-value:7.43E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.20|P-value:2.75E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.47|P-value:8.74E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.87|P-value:9.42E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:5.50|P-value:1.40E-9 ID:SGTC_1304|Compound:1165-0502|FD-Score:-2.87|P-value:9.80E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.59|P-value:3.39E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:-4.31|P-value:1.60E-6 ID:SGTC_1523|Compound:st012844|FD-Score:-3.38|P-value:1.31E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.35|P-value:1.48E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:5.45|P-value:1.88E-9 ID:SGTC_1838|Compound:st055369|FD-Score:-3.40|P-value:1.20E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-3.87|P-value:1.44E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.72|P-value:2.96E-5 ID:SGTC_1897|Compound:st060201|FD-Score:-3.49|P-value:8.15E-5 ID:SGTC_2102|Compound:5377816|FD-Score:4.02|P-value:6.95E-6 ID:SGTC_2308|Compound:7584454|FD-Score:3.64|P-value:4.15E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.07|P-value:4.46E-4 ID:SGTC_2398|Compound:5228213|FD-Score:2.91|P-value:8.26E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.81|P-value:1.90E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.89|P-value:9.00E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.24|P-value:2.32E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.32|P-value:1.66E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-4.64|P-value:2.70E-7 ID:SGTC_2693|Compound:st077581|FD-Score:3.45|P-value:9.67E-5 ID:SGTC_2788|Compound:5282734|FD-Score:3.51|P-value:7.33E-5 ID:SGTC_2789|Compound:5281112|FD-Score:-3.80|P-value:1.99E-5 ID:SGTC_3005|Compound:9076496|FD-Score:-3.53|P-value:6.93E-5 ID:SGTC_3009|Compound:9080819|FD-Score:2.92|P-value:8.02E-4 ID:SGTC_3256|Compound:9138902|FD-Score:-2.93|P-value:7.76E-4 ID:SGTC_3330|Compound:9141424|FD-Score:2.88|P-value:9.23E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.37|P-value:1.32E-4

Top fitness defect scores for YDR305C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_798 1287-0182 6.01 476.0 µM 3.96E-11 6 9.08E-10
2 SGTC_539 4859-0462 5.51 2.5 µM 1.30E-9 RNA pol III & RNase P/MRP 5 1.83E-8
3 SGTC_1292 0kpi-0043 5.50 232.0 µM 1.40E-9 3 1.94E-8
4 SGTC_1527 coumarin 5.45 137.0 µM 1.88E-9 2 2.50E-8
5 SGTC_1311 1190-0148 4.59 100.0 µM 3.39E-7 azole & statin 18 2.18E-6
6 SGTC_427 1354-0053 4.07 47.3 µM 5.31E-6 18 2.33E-5
7 SGTC_2102 5377816 4.02 72.8 µM 6.95E-6 28 2.93E-5
8 SGTC_41 0478-0632 3.88 82.6 µM 1.33E-5 30 5.13E-5
9 SGTC_39 0986-0283 3.79 58.4 µM 2.09E-5 calcium & mitochondrial duress 42 7.57E-5
10 SGTC_2308 7584454 3.64 197.6 µM 4.15E-5 32 1.37E-4
11 SGTC_155 k072-0202 3.54 43.6 µM 6.51E-5 25 2.02E-4
12 SGTC_2788 5282734 3.51 71.4 µM 7.33E-5 70 2.24E-4
13 SGTC_1073 triclabendazole 3.47 3.1 µM 8.74E-5 45 2.60E-4
14 SGTC_2693 st077581 3.45 40.7 µM 9.67E-5 59 2.84E-4
15 SGTC_3334 9142812 3.37 21.9 µM 1.32E-4 46 3.71E-4
16 SGTC_705 1124-0212 3.27 310.0 µM 2.06E-4 39 5.45E-4
17 SGTC_2610 ononetin 3.24 44.2 µM 2.32E-4 77 6.05E-4
18 SGTC_2354 9060492 3.07 162.0 µM 4.46E-4 58 0.00106
19 SGTC_227 fluconazole 3.05 33.5 µM 4.91E-4 azole & statin 138 0.00116
20 SGTC_735 3076-0345 3.03 636.0 µM 5.23E-4 80 0.00122

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.51E-19 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.122 1.31E-12 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.111 1.19E-10 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.108 3.05E-10 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.105 1.08E-9 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.097 2.00E-8 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.095 3.38E-8 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.094 4.72E-8 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.092 1.07E-7 YDR046C BAP3 hom Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication
0.089 2.32E-7 YDR246W TRS23 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
0.085 7.43E-7 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.083 1.63E-6 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.081 2.59E-6 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.079 4.51E-6 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.077 7.50E-6 YIL173W VTH1 hom Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting