YDR310C / SUM1

Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR310C / SUM1

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:-3.38|P-value:5.18E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.27|P-value:7.68E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.21|P-value:9.29E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.33|P-value:1.83E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.91|P-value:9.52E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.97|P-value:7.73E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.61|P-value:2.87E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.38|P-value:6.41E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.50|P-value:2.61E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.45|P-value:5.16E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.13|P-value:4.76E-7 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.77|P-value:1.65E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.08|P-value:6.08E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.36|P-value:9.34E-13 ID:SGTC_558|Compound:k064-0027|FD-Score:4.50|P-value:8.68E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:-4.19|P-value:2.52E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.52|P-value:8.02E-6 ID:SGTC_645|Compound:0845-0943|FD-Score:3.31|P-value:8.00E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.70|P-value:2.11E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.76|P-value:1.67E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.70|P-value:2.12E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:4.24|P-value:2.62E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:4.13|P-value:4.02E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:6.07|P-value:3.22E-9 ID:SGTC_922|Compound:1866-0035|FD-Score:4.00|P-value:6.87E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:5.56|P-value:5.52E-8 ID:SGTC_996|Compound:3970-0799|FD-Score:6.96|P-value:1.42E-11 ID:SGTC_1070|Compound:indatraline|FD-Score:4.29|P-value:2.14E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.40|P-value:6.00E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.55|P-value:7.14E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.82|P-value:1.36E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.51|P-value:4.21E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.37|P-value:1.44E-7 ID:SGTC_2016|Compound:5121758|FD-Score:6.72|P-value:6.61E-11 ID:SGTC_2021|Compound:4019055|FD-Score:15.90|P-value:9.61E-53 ID:SGTC_2024|Compound:5144227|FD-Score:3.91|P-value:9.72E-5 ID:SGTC_2126|Compound:5251174|FD-Score:5.59|P-value:4.59E-8 ID:SGTC_2132|Compound:5317594|FD-Score:4.95|P-value:1.15E-6 ID:SGTC_2134|Compound:5324836|FD-Score:3.37|P-value:6.57E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-4.45|P-value:8.43E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.43|P-value:1.17E-5 ID:SGTC_2696|Compound:st077691|FD-Score:5.08|P-value:6.04E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.87|P-value:1.13E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.38|P-value:1.11E-5 ID:SGTC_2811|Compound:7967822|FD-Score:4.32|P-value:1.85E-5 ID:SGTC_2896|Compound:9052656|FD-Score:7.69|P-value:8.94E-14 ID:SGTC_2960|Compound:9079389|FD-Score:-3.23|P-value:8.72E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.57|P-value:3.39E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.43|P-value:5.40E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.71|P-value:2.00E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.12|P-value:4.29E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.38|P-value:5.18E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.27|P-value:7.68E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.21|P-value:9.29E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:4.33|P-value:1.83E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.91|P-value:9.52E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:3.97|P-value:7.73E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.61|P-value:2.87E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.38|P-value:6.41E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.50|P-value:2.61E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:3.45|P-value:5.16E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.13|P-value:4.76E-7 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.77|P-value:1.65E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.08|P-value:6.08E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:7.36|P-value:9.34E-13 ID:SGTC_558|Compound:k064-0027|FD-Score:4.50|P-value:8.68E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:-4.19|P-value:2.52E-5 ID:SGTC_609|Compound:0986-0026|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:4.52|P-value:8.02E-6 ID:SGTC_645|Compound:0845-0943|FD-Score:3.31|P-value:8.00E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.70|P-value:2.11E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.76|P-value:1.67E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:3.70|P-value:2.12E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:4.24|P-value:2.62E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:4.13|P-value:4.02E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:6.07|P-value:3.22E-9 ID:SGTC_922|Compound:1866-0035|FD-Score:4.00|P-value:6.87E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:5.56|P-value:5.52E-8 ID:SGTC_996|Compound:3970-0799|FD-Score:6.96|P-value:1.42E-11 ID:SGTC_1070|Compound:indatraline|FD-Score:4.29|P-value:2.14E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.40|P-value:6.00E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:4.55|P-value:7.14E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.82|P-value:1.36E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.51|P-value:4.21E-4 ID:SGTC_2014|Compound:4013930|FD-Score:5.37|P-value:1.44E-7 ID:SGTC_2016|Compound:5121758|FD-Score:6.72|P-value:6.61E-11 ID:SGTC_2021|Compound:4019055|FD-Score:15.90|P-value:9.61E-53 ID:SGTC_2024|Compound:5144227|FD-Score:3.91|P-value:9.72E-5 ID:SGTC_2126|Compound:5251174|FD-Score:5.59|P-value:4.59E-8 ID:SGTC_2132|Compound:5317594|FD-Score:4.95|P-value:1.15E-6 ID:SGTC_2134|Compound:5324836|FD-Score:3.37|P-value:6.57E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-4.45|P-value:8.43E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.43|P-value:1.17E-5 ID:SGTC_2696|Compound:st077691|FD-Score:5.08|P-value:6.04E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.87|P-value:1.13E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.38|P-value:1.11E-5 ID:SGTC_2811|Compound:7967822|FD-Score:4.32|P-value:1.85E-5 ID:SGTC_2896|Compound:9052656|FD-Score:7.69|P-value:8.94E-14 ID:SGTC_2960|Compound:9079389|FD-Score:-3.23|P-value:8.72E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.57|P-value:3.39E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.43|P-value:5.40E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.71|P-value:2.00E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.12|P-value:4.29E-5

Top fitness defect scores for YDR310C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 15.90 173.0 µM 9.61E-53 endomembrane recycling 1 3.74E-57
2 SGTC_2896 9052656 7.69 71.4 µM 8.94E-14 endomembrane recycling 22 7.14E-15
3 SGTC_453 enantio-paf c16 7.36 10.0 µM 9.34E-13 20 9.13E-14
4 SGTC_996 3970-0799 6.96 1.8 µM 1.42E-11 26 1.75E-12
5 SGTC_2016 5121758 6.72 140.0 µM 6.61E-11 redox potentiating 12 9.31E-12
6 SGTC_312 4092-0653 6.50 6.8 µM 2.61E-10 ergosterol depletion effects on membrane 33 4.14E-11
7 SGTC_866 0495-0101 6.07 262.0 µM 3.22E-9 60S ribosome export 4 6.33E-10
8 SGTC_2126 5251174 5.59 33.9 µM 4.59E-8 4 1.14E-8
9 SGTC_924 2046-0044 5.56 21.3 µM 5.52E-8 4 1.39E-8
10 SGTC_2014 4013930 5.37 200.0 µM 1.44E-7 4 3.94E-8
11 SGTC_377 3970-0964 5.13 33.1 µM 4.76E-7 25 1.44E-7
12 SGTC_2696 st077691 5.08 74.3 µM 6.04E-7 11 1.86E-7
13 SGTC_445 e6 berbamine 5.08 66.0 µM 6.08E-7 NEO1-PIK1 59 1.88E-7
14 SGTC_2132 5317594 4.95 122.7 µM 1.15E-6 SWF1 & branched chain AA biosynthesis 18 3.76E-7
15 SGTC_1100 amiodarone 4.55 5.1 µM 7.14E-6 7 2.72E-6
16 SGTC_625 k213-0058 4.52 121.0 µM 8.02E-6 translation 72 3.09E-6
17 SGTC_558 k064-0027 4.50 21.3 µM 8.68E-6 DNA damage response 18 3.37E-6
18 SGTC_2593 nobiletin 4.43 86.2 µM 1.17E-5 17 4.64E-6
19 SGTC_207 4185-0010 4.33 4.5 µM 1.83E-5 endomembrane recycling 77 7.58E-6
20 SGTC_2811 7967822 4.32 32.5 µM 1.85E-5 15 7.66E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 1.64E-43 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.214 3.24E-36 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.200 1.09E-31 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.183 1.48E-26 YOR279C RFM1 hom DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
0.176 8.12E-25 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.172 9.58E-24 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.165 6.85E-22 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.164 1.06E-21 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162 4.00E-21 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.159 2.53E-20 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.158 4.77E-20 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.156 1.09E-19 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.152 1.01E-18 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.152 1.05E-18 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.148 7.80E-18 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern