YDR313C / PIB1

RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR313C / PIB1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.66|P-value:9.68E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:5.49|P-value:1.14E-8 ID:SGTC_17|Compound:0960-0276|FD-Score:3.81|P-value:5.22E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.14|P-value:7.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.42|P-value:2.32E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.90|P-value:3.68E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.37|P-value:3.01E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.08|P-value:8.27E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.80|P-value:5.43E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.33|P-value:3.56E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.32|P-value:3.43E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.12|P-value:7.65E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.40|P-value:2.76E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.19|P-value:5.59E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.06|P-value:9.19E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.32|P-value:3.40E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.08|P-value:8.70E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.14|P-value:1.25E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.28|P-value:3.95E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.10|P-value:8.16E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.40|P-value:2.72E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.11|P-value:7.49E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.08|P-value:8.82E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.35|P-value:3.35E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.35|P-value:2.63E-8 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.02|P-value:9.97E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.75|P-value:6.68E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.53|P-value:1.62E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.73|P-value:6.93E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.99|P-value:2.43E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-4.40|P-value:3.52E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.09|P-value:8.51E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.17|P-value:5.97E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.63|P-value:1.03E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.12|P-value:7.21E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-3.17|P-value:5.85E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.77|P-value:6.16E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.15|P-value:6.41E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.45|P-value:2.22E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.95|P-value:2.88E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.27|P-value:4.44E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.23|P-value:5.14E-4 ID:SGTC_2395|Compound:5646831|FD-Score:6.77|P-value:2.62E-12 ID:SGTC_2736|Compound:butenafine|FD-Score:5.05|P-value:1.37E-7 ID:SGTC_2847|Compound:9005661|FD-Score:3.69|P-value:8.68E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.13|P-value:6.95E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.60|P-value:1.18E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.81|P-value:5.37E-5 ID:SGTC_1|Compound:0258-0098|FD-Score:3.66|P-value:9.68E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:5.49|P-value:1.14E-8 ID:SGTC_17|Compound:0960-0276|FD-Score:3.81|P-value:5.22E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.14|P-value:7.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.42|P-value:2.32E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.90|P-value:3.68E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:3.37|P-value:3.01E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.08|P-value:8.27E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.80|P-value:5.43E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:3.33|P-value:3.56E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.32|P-value:3.43E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.12|P-value:7.65E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.40|P-value:2.76E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.19|P-value:5.59E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:3.06|P-value:9.19E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.32|P-value:3.40E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.08|P-value:8.70E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.14|P-value:1.25E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.28|P-value:3.95E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.10|P-value:8.16E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.40|P-value:2.72E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:-3.11|P-value:7.49E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.08|P-value:8.82E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.35|P-value:3.35E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.35|P-value:2.63E-8 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.02|P-value:9.97E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.58|P-value:1.36E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.75|P-value:6.68E-5 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.53|P-value:1.62E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.73|P-value:6.93E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.99|P-value:2.43E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-4.40|P-value:3.52E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.09|P-value:8.51E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-3.17|P-value:5.97E-4 ID:SGTC_1764|Compound:st044502|FD-Score:-3.63|P-value:1.03E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.12|P-value:7.21E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-3.17|P-value:5.85E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.77|P-value:6.16E-5 ID:SGTC_2049|Compound:5262831|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.15|P-value:6.41E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.45|P-value:2.22E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.95|P-value:2.88E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.27|P-value:4.44E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.23|P-value:5.14E-4 ID:SGTC_2395|Compound:5646831|FD-Score:6.77|P-value:2.62E-12 ID:SGTC_2736|Compound:butenafine|FD-Score:5.05|P-value:1.37E-7 ID:SGTC_2847|Compound:9005661|FD-Score:3.69|P-value:8.68E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.13|P-value:6.95E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.60|P-value:1.18E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.81|P-value:5.37E-5

Top fitness defect scores for YDR313C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2395 5646831 6.77 180.2 µM 2.62E-12 4 6.22E-12
2 SGTC_8 0354-0001 5.49 70.0 µM 1.14E-8 32 2.00E-8
3 SGTC_1134 3477-0009 5.35 42.5 µM 2.63E-8 16 4.49E-8
4 SGTC_2736 butenafine 5.05 14.7 µM 1.37E-7 15 2.21E-7
5 SGTC_798 1287-0182 4.14 476.0 µM 1.25E-5 17 1.72E-5
6 SGTC_1244 0416-0015 3.99 52.5 µM 2.43E-5 ERG2 32 3.26E-5
7 SGTC_2305 7443522 3.95 69.2 µM 2.88E-5 15 3.85E-5
8 SGTC_106 0092-0003 3.90 11.6 µM 3.68E-5 copper-dependent oxidative stress 19 4.88E-5
9 SGTC_17 0960-0276 3.81 49.8 µM 5.22E-5 39 6.84E-5
10 SGTC_3265 9137266 3.81 49.5 µM 5.37E-5 10 7.02E-5
11 SGTC_220 paclitaxel 3.80 373.4 µM 5.43E-5 12 7.10E-5
12 SGTC_1900 st060200 3.77 72.8 µM 6.16E-5 26 8.01E-5
13 SGTC_1202 1988-0068 3.75 29.6 µM 6.68E-5 RNA processing & uracil transport 34 8.67E-5
14 SGTC_2847 9005661 3.69 71.4 µM 8.68E-5 10 1.12E-4
15 SGTC_1 0258-0098 3.66 57.4 µM 9.68E-5 heme biosynthesis & mitochondrial translocase 11 1.24E-4
16 SGTC_1194 1488-0194 3.58 225.0 µM 1.36E-4 45 1.72E-4
17 SGTC_1222 0366-0074 3.53 1.2 µM 1.62E-4 TSC3-RPN4 28 2.05E-4
18 SGTC_2135 5326629 3.45 150.4 µM 2.22E-4 RPP1 & pyrimidine depletion 44 2.77E-4
19 SGTC_887 0885-0007 3.40 9.6 µM 2.72E-4 endomembrane recycling 59 3.37E-4
20 SGTC_463 ikarugamyin 3.40 104.0 µM 2.76E-4 4 3.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.24E-17 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.092 8.64E-8 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.087 4.07E-7 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.086 5.40E-7 YDR229W IVY1 hom Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
0.085 7.25E-7 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.085 9.12E-7 YDR363W ESC2 hom Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member
0.084 1.14E-6 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.083 1.61E-6 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.083 1.61E-6 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.083 1.71E-6 YOL087C DUF1 hom Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
0.082 1.81E-6 YAL054C ACS1 hom Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
0.082 2.19E-6 YPL099C AIM43 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.081 2.31E-6 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
0.081 2.87E-6 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.080 3.44E-6 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine