YDR316W / OMS1

Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR316W / OMS1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:3.67|P-value:4.42E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.60|P-value:5.50E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.49|P-value:7.81E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.49|P-value:7.72E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.81|P-value:2.50E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.63|P-value:1.31E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:5.01|P-value:2.74E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.80|P-value:2.83E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.61|P-value:4.90E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.60|P-value:5.46E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.29|P-value:5.04E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.44|P-value:2.77E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.43|P-value:2.96E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.43|P-value:9.31E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.48|P-value:8.14E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:6.50|P-value:1.79E-9 ID:SGTC_1725|Compound:st036284|FD-Score:3.48|P-value:8.15E-4 ID:SGTC_1753|Compound:st043925|FD-Score:4.27|P-value:5.38E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.90|P-value:2.06E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.79|P-value:2.92E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.61|P-value:9.49E-10 ID:SGTC_2184|Compound:6075246|FD-Score:-3.53|P-value:6.26E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.77|P-value:3.11E-4 ID:SGTC_2244|Compound:6635614|FD-Score:4.37|P-value:3.68E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.71|P-value:3.89E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.92|P-value:1.68E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.50|P-value:2.19E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.88|P-value:2.19E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.84|P-value:2.52E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.55|P-value:6.42E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.23|P-value:6.25E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:6.16|P-value:1.10E-8 ID:SGTC_2760|Compound:etidronate|FD-Score:3.46|P-value:8.47E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.39|P-value:3.36E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.42|P-value:9.84E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.82|P-value:2.69E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.22|P-value:6.38E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-4.35|P-value:3.53E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-3.73|P-value:3.28E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.61|P-value:5.29E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.86|P-value:2.34E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.28|P-value:4.60E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.66|P-value:4.47E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.85|P-value:2.43E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.49|P-value:7.86E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.67|P-value:4.42E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.60|P-value:5.50E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.49|P-value:7.81E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.49|P-value:7.72E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.81|P-value:2.50E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.63|P-value:1.31E-5 ID:SGTC_244|Compound:nsc-207895|FD-Score:5.01|P-value:2.74E-6 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.80|P-value:2.83E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:-3.61|P-value:4.90E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.60|P-value:5.46E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:4.29|P-value:5.04E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:4.44|P-value:2.77E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.43|P-value:2.96E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.43|P-value:9.31E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.48|P-value:8.14E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:6.50|P-value:1.79E-9 ID:SGTC_1725|Compound:st036284|FD-Score:3.48|P-value:8.15E-4 ID:SGTC_1753|Compound:st043925|FD-Score:4.27|P-value:5.38E-5 ID:SGTC_1817|Compound:st052116|FD-Score:3.90|P-value:2.06E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.79|P-value:2.92E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.61|P-value:9.49E-10 ID:SGTC_2184|Compound:6075246|FD-Score:-3.53|P-value:6.26E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.77|P-value:3.11E-4 ID:SGTC_2244|Compound:6635614|FD-Score:4.37|P-value:3.68E-5 ID:SGTC_2245|Compound:6637752|FD-Score:3.71|P-value:3.89E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.92|P-value:1.68E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.50|P-value:2.19E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.88|P-value:2.19E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.84|P-value:2.52E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.55|P-value:6.42E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.23|P-value:6.25E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:6.16|P-value:1.10E-8 ID:SGTC_2760|Compound:etidronate|FD-Score:3.46|P-value:8.47E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.39|P-value:3.36E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.42|P-value:9.84E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.82|P-value:2.69E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.22|P-value:6.38E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-4.35|P-value:3.53E-5 ID:SGTC_3026|Compound:9090633|FD-Score:-3.73|P-value:3.28E-4 ID:SGTC_3041|Compound:9091929|FD-Score:3.61|P-value:5.29E-4 ID:SGTC_3099|Compound:9120367|FD-Score:3.86|P-value:2.34E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-4.28|P-value:4.60E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.66|P-value:4.47E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.85|P-value:2.43E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.49|P-value:7.86E-4

Top fitness defect scores for YDR316W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1926 methyl fluorone black 6.61 53.6 µM 9.49E-10 DNA intercalators 17 1.87E-11
2 SGTC_1520 flindersine 6.50 88.0 µM 1.79E-9 7 4.03E-11
3 SGTC_2756 carbadox 6.16 75.1 µM 1.10E-8 16 3.59E-10
4 SGTC_244 nsc-207895 5.01 1.3 µM 2.74E-6 DNA damage response 11 2.74E-7
5 SGTC_236 1509-0011 4.63 5.3 µM 1.31E-5 350 1.79E-6
6 SGTC_2343 7990716 4.50 14.8 µM 2.19E-5 10 3.32E-6
7 SGTC_1066 ketoconazole 4.44 628.0 nM 2.77E-5 10 4.41E-6
8 SGTC_1089 terbinafine 4.43 2.2 µM 2.96E-5 8 4.77E-6
9 SGTC_2781 5567276 4.39 71.4 µM 3.36E-5 34 5.56E-6
10 SGTC_2244 6635614 4.37 200.0 µM 3.68E-5 2 6.20E-6
11 SGTC_573 3702-0553 4.29 84.7 µM 5.04E-5 9 9.04E-6
12 SGTC_1753 st043925 4.27 64.0 µM 5.38E-5 5 9.78E-6
13 SGTC_2751 anetholtrithion 4.23 17.2 µM 6.25E-5 23 1.17E-5
14 SGTC_2958 9077254 4.22 16.7 µM 6.38E-5 24 1.20E-5
15 SGTC_1817 st052116 3.90 64.4 µM 2.06E-4 RNA processing & uracil transport 15 4.89E-5
16 SGTC_2356 9061756 3.88 189.0 µM 2.19E-4 10 5.28E-5
17 SGTC_3099 9120367 3.86 49.5 µM 2.34E-4 20 5.71E-5
18 SGTC_3218 9131285 3.85 49.5 µM 2.43E-4 endomembrane recycling 50 5.97E-5
19 SGTC_2364 9055074 3.84 200.0 µM 2.52E-4 22 6.22E-5
20 SGTC_2787 5284540 3.82 71.4 µM 2.69E-4 27 6.75E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 8.17E-16 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.126 2.12E-13 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.121 1.84E-12 YJR077C MIR1 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
0.115 2.41E-11 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.114 3.70E-11 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.113 4.87E-11 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.111 1.29E-10 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.105 1.27E-9 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.103 1.94E-9 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.102 3.69E-9 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.101 4.48E-9 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.098 1.34E-8 YLR436C ECM30 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.096 2.50E-8 YDR512C EMI1 hom Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs
0.096 2.84E-8 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.095 3.30E-8 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding