HIPHOP chemogenomics database

YDR316W / OMS1

Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR316W / OMS1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR316W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1926	methyl fluorone black	6.61	53.6 µM	9.49E-10	DNA intercalators	17	1.87E-11
2	SGTC_1520	flindersine	6.50	88.0 µM	1.79E-9		7	4.03E-11
3	SGTC_2756	carbadox	6.16	75.1 µM	1.10E-8		16	3.59E-10
4	SGTC_244	nsc-207895	5.01	1.3 µM	2.74E-6	DNA damage response	11	2.74E-7
5	SGTC_236	1509-0011	4.63	5.3 µM	1.31E-5		350	1.79E-6
6	SGTC_2343	7990716	4.50	14.8 µM	2.19E-5		10	3.32E-6
7	SGTC_1066	ketoconazole	4.44	628.0 nM	2.77E-5		10	4.41E-6
8	SGTC_1089	terbinafine	4.43	2.2 µM	2.96E-5		8	4.77E-6
9	SGTC_2781	5567276	4.39	71.4 µM	3.36E-5		34	5.56E-6
10	SGTC_2244	6635614	4.37	200.0 µM	3.68E-5		2	6.20E-6
11	SGTC_573	3702-0553	4.29	84.7 µM	5.04E-5		9	9.04E-6
12	SGTC_1753	st043925	4.27	64.0 µM	5.38E-5		5	9.78E-6
13	SGTC_2751	anetholtrithion	4.23	17.2 µM	6.25E-5		23	1.17E-5
14	SGTC_2958	9077254	4.22	16.7 µM	6.38E-5		24	1.20E-5
15	SGTC_1817	st052116	3.90	64.4 µM	2.06E-4	RNA processing & uracil transport	15	4.89E-5
16	SGTC_2356	9061756	3.88	189.0 µM	2.19E-4		10	5.28E-5
17	SGTC_3099	9120367	3.86	49.5 µM	2.34E-4		20	5.71E-5
18	SGTC_3218	9131285	3.85	49.5 µM	2.43E-4	endomembrane recycling	50	5.97E-5
19	SGTC_2364	9055074	3.84	200.0 µM	2.52E-4		22	6.22E-5
20	SGTC_2787	5284540	3.82	71.4 µM	2.69E-4		27	6.75E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.139	8.17E-16	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit
0.126	2.12E-13	YER099C	PRS2	hom	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.121	1.84E-12	YJR077C	MIR1	hom	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
0.115	2.41E-11	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.114	3.70E-11	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.113	4.87E-11	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.111	1.29E-10	YEL006W	YEA6	hom	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.105	1.27E-9	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.103	1.94E-9	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.102	3.69E-9	YOL137W	BSC6	hom	Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.101	4.48E-9	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.098	1.34E-8	YLR436C	ECM30	hom	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
0.096	2.50E-8	YDR512C	EMI1	hom	Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs
0.096	2.84E-8	YGR112W	SHY1	hom	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.095	3.30E-8	YBL021C	HAP3	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding