HIPHOP chemogenomics database

YDR317W / HIM1

Protein of unknown function involved in DNA repair

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR317W / HIM1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR317W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1308	1187-1617	9.31	41.4 µM	5.18E-24	fatty acid desaturase (OLE1)	4	6.55E-21
2	SGTC_788	1182-0090	7.96	188.0 µM	4.63E-18	endomembrane recycling	20	8.91E-16
3	SGTC_2398	5228213	6.85	48.8 µM	7.07E-14	iron homeostasis	5	3.63E-12
4	SGTC_486	niguldipine	6.38	82.0 µM	2.92E-12	amide catabolism	6	9.01E-11
5	SGTC_457	grayanotoxin iii	6.25	135.0 µM	7.65E-12		21	2.07E-10
6	SGTC_15	0266-0086	6.01	27.1 µM	4.50E-11	endomembrane recycling	20	9.54E-10
7	SGTC_2688	kanamycin b	5.66	96.7 µM	5.07E-10	calcium & mitochondrial duress	186	7.72E-9
8	SGTC_2021	4019055	5.39	173.0 µM	2.96E-9	endomembrane recycling	56	3.54E-8
9	SGTC_1230	0170-0365	5.31	3.8 µM	5.01E-9	endomembrane recycling	31	5.59E-8
10	SGTC_2322	7413319	5.21	38.2 µM	9.45E-9	ERAD & cell cycle	87	9.66E-8
11	SGTC_1800	st050079	5.05	29.1 µM	2.52E-8	NEO1-PIK1	72	2.26E-7
12	SGTC_1803	st050068	4.56	52.4 µM	4.13E-7	NEO1-PIK1	136	2.53E-6
13	SGTC_1754	st042065	4.50	16.1 µM	5.70E-7	NEO1-PIK1	151	3.34E-6
14	SGTC_114	0364-0001	4.39	490.3 µM	1.07E-6		34	5.74E-6
15	SGTC_649	1123-0311	4.36	367.0 µM	1.24E-6	endomembrane recycling	54	6.54E-6
16	SGTC_16	erodoxin	4.27	22.8 µM	1.93E-6	unfolded protein response	56	9.59E-6
17	SGTC_1818	st052136	4.11	56.3 µM	4.39E-6	NEO1-PIK1	43	1.95E-5
18	SGTC_1339	1486-1321	4.04	22.7 µM	6.23E-6	ERG2	19	2.64E-5
19	SGTC_515	4092-1064	4.02	102.0 µM	6.95E-6	plasma membrane duress	59	2.91E-5
20	SGTC_2006	4011487	3.79	200.0 µM	2.12E-5	endomembrane recycling	87	7.62E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.315	4.49E-78	YDR084C	TVP23	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.288	7.29E-65	YOL144W	NOP8	het	Nucleolar protein required for 60S ribosomal subunit biogenesis
0.264	1.46E-54	YNR044W	AGA1	hom	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.247	7.63E-48	YLR360W	VPS38	hom	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.234	4.96E-43	YJL086C_d	YJL086C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.226	3.71E-40	YOR115C	TRS33	hom	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.223	5.80E-39	YPL145C	KES1	hom	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.222	8.32E-39	YGR166W	TRS65	hom	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.220	5.38E-38	YNL077W	APJ1	hom	Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.216	1.17E-36	YEL048C	TCA17	hom	Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
0.214	3.97E-36	YMR134W	ERG29	het	Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.212	2.15E-35	YNL294C	RIM21	hom	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.210	1.26E-34	YNL267W	PIK1	het	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.209	1.85E-34	YGR202C	PCT1	hom	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.207	8.26E-34	YGR122W	YGR122W	hom	Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress