YDR322C-A / TIM11

Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR322C-A / TIM11

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.26|P-value:7.16E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.01|P-value:4.76E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.38|P-value:1.08E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.36|P-value:9.58E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.36|P-value:5.24E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.83|P-value:1.13E-17 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.60|P-value:2.24E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.66|P-value:2.32E-8 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.86|P-value:1.73E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.53|P-value:2.87E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.82|P-value:1.02E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.54|P-value:2.76E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.66|P-value:3.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.90|P-value:7.34E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.53|P-value:5.62E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.52|P-value:5.75E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.01|P-value:4.75E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.56|P-value:4.91E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.69|P-value:3.24E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.24|P-value:1.90E-5 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.22|P-value:8.08E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.20|P-value:8.75E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.85|P-value:8.99E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.94|P-value:1.31E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.90|P-value:1.07E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-4.17|P-value:5.37E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.30|P-value:6.35E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.57|P-value:1.07E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.47|P-value:6.85E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.54|P-value:2.76E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.40|P-value:8.48E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.40|P-value:8.44E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.50|P-value:3.25E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.34|P-value:5.57E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.87|P-value:8.37E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.52|P-value:5.66E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-7.31|P-value:3.66E-12 ID:SGTC_2526|Compound:patulin|FD-Score:-4.43|P-value:1.90E-5 ID:SGTC_2711|Compound:st079103|FD-Score:3.66|P-value:1.82E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.34|P-value:5.53E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.85|P-value:9.02E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.26|P-value:7.16E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:4.01|P-value:4.76E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.38|P-value:1.08E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.36|P-value:9.58E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.36|P-value:5.24E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.83|P-value:1.13E-17 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.60|P-value:2.24E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.66|P-value:2.32E-8 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.86|P-value:1.73E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.53|P-value:2.87E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.82|P-value:1.02E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.58|P-value:2.45E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.54|P-value:2.76E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:-3.66|P-value:3.51E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.90|P-value:7.34E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:3.43|P-value:4.03E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.53|P-value:5.62E-6 ID:SGTC_974|Compound:1326-0144|FD-Score:-3.52|P-value:5.75E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.63|P-value:2.03E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.01|P-value:4.75E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:4.56|P-value:4.91E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.69|P-value:3.24E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.24|P-value:1.90E-5 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.22|P-value:8.08E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.20|P-value:8.75E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.85|P-value:8.99E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.94|P-value:1.31E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.90|P-value:1.07E-6 ID:SGTC_1673|Compound:st016611|FD-Score:-4.17|P-value:5.37E-5 ID:SGTC_1676|Compound:st018489|FD-Score:3.30|P-value:6.35E-4 ID:SGTC_1678|Compound:st019265|FD-Score:-4.57|P-value:1.07E-5 ID:SGTC_1752|Compound:st044819|FD-Score:-3.47|P-value:6.85E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.54|P-value:2.76E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-3.40|P-value:8.48E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-3.40|P-value:8.44E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.50|P-value:3.25E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.34|P-value:5.57E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.87|P-value:8.37E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.52|P-value:5.66E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-7.31|P-value:3.66E-12 ID:SGTC_2526|Compound:patulin|FD-Score:-4.43|P-value:1.90E-5 ID:SGTC_2711|Compound:st079103|FD-Score:3.66|P-value:1.82E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.34|P-value:5.53E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.85|P-value:9.02E-5

Top fitness defect scores for YDR322C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.83 5.3 µM 1.13E-17 224 5.07E-19
2 SGTC_386 1509-0011 5.66 3.1 µM 2.32E-8 95 7.62E-9
3 SGTC_1635 st007035 4.90 42.4 µM 1.07E-6 171 4.90E-7
4 SGTC_1048 3161-0300 4.56 24.5 µM 4.91E-6 14 2.56E-6
5 SGTC_953 1188-0045 4.53 9.7 µM 5.62E-6 60S ribosome export 15 2.97E-6
6 SGTC_77 0828-0286 4.38 12.5 µM 1.08E-5 TSC3-RPN4 25 6.04E-6
7 SGTC_1080 nisoldipine 4.24 24.4 µM 1.90E-5 TSC3-RPN4 22 1.11E-5
8 SGTC_1045 1348-1485 4.01 165.0 µM 4.75E-5 27 2.98E-5
9 SGTC_74 000s-0487 4.01 160.3 µM 4.76E-5 20 2.99E-5
10 SGTC_669 0108-0021 3.90 26.2 µM 7.34E-5 fatty acid desaturase (OLE1) 83 4.77E-5
11 SGTC_2130 NSC 7 3.87 2.5 µM 8.37E-5 copper-dependent oxidative stress 26 5.50E-5
12 SGTC_1421 4029-0249 3.85 71.4 µM 8.99E-5 17 5.93E-5
13 SGTC_3208 9114115 3.85 49.5 µM 9.02E-5 40 5.95E-5
14 SGTC_533 1222-0222 3.82 6.7 µM 1.02E-4 PDR1 32 6.81E-5
15 SGTC_2711 st079103 3.66 59.1 µM 1.82E-4 9 1.27E-4
16 SGTC_991 3996-0057 3.63 64.7 µM 2.03E-4 27 1.43E-4
17 SGTC_273 hydroxyurea 3.60 18.1 mM 2.24E-4 heme biosynthesis & mitochondrial translocase 43 1.59E-4
18 SGTC_540 1187-0821 3.58 17.3 µM 2.45E-4 25 1.75E-4
19 SGTC_1956 st077085 3.54 54.0 µM 2.76E-4 27 1.99E-4
20 SGTC_581 0958-0271 3.54 211.0 µM 2.76E-4 68 1.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.357 2.42E-101 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.355 5.04E-100 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.347 1.79E-95 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.339 5.46E-91 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.331 1.75E-86 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.329 3.69E-85 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.326 8.96E-84 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.321 2.07E-81 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.319 6.82E-80 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.317 3.85E-79 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.310 2.47E-75 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.309 3.87E-75 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.302 7.63E-72 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.301 3.97E-71 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.293 3.68E-67 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase