YDR322W / MRPL35

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR322W / MRPL35

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.25|P-value:8.07E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.39|P-value:3.11E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.37|P-value:5.83E-18 ID:SGTC_204|Compound:1543-0184|FD-Score:3.61|P-value:4.94E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.60|P-value:5.91E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.50|P-value:2.08E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:7.35|P-value:9.55E-12 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.46|P-value:3.03E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.12|P-value:8.54E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.81|P-value:2.55E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.41|P-value:9.26E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.59|P-value:5.18E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.83|P-value:2.38E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.44|P-value:8.30E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.00|P-value:2.10E-8 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.56|P-value:5.76E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.40|P-value:9.62E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.15|P-value:7.44E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.29|P-value:4.41E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.26|P-value:5.05E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.25|P-value:5.75E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.02|P-value:1.20E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-5.89|P-value:3.77E-8 ID:SGTC_2495|Compound:cafestol|FD-Score:3.99|P-value:1.33E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.52|P-value:6.48E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.22|P-value:5.93E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.07|P-value:9.97E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.26|P-value:5.10E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.98|P-value:1.42E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.18|P-value:6.73E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.85|P-value:2.20E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-7.84|P-value:4.02E-13 ID:SGTC_2878|Compound:9043973|FD-Score:-5.53|P-value:2.20E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-3.87|P-value:2.05E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-4.63|P-value:1.19E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.55|P-value:1.60E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.00|P-value:1.32E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.89|P-value:1.94E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.06|P-value:1.03E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.31|P-value:4.08E-5 ID:SGTC_3212|Compound:9128307|FD-Score:5.14|P-value:1.37E-6 ID:SGTC_3261|Compound:9137475|FD-Score:-3.53|P-value:6.34E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.35|P-value:5.22E-7 ID:SGTC_3346|Compound:9158254|FD-Score:4.22|P-value:5.81E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.50|P-value:7.03E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.25|P-value:8.07E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.39|P-value:3.11E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.91|P-value:1.78E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.37|P-value:5.83E-18 ID:SGTC_204|Compound:1543-0184|FD-Score:3.61|P-value:4.94E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.60|P-value:5.91E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.50|P-value:2.08E-18 ID:SGTC_310|Compound:1273-0058|FD-Score:7.35|P-value:9.55E-12 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.46|P-value:3.03E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:4.12|P-value:8.54E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.81|P-value:2.55E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.41|P-value:9.26E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.59|P-value:5.18E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.83|P-value:2.38E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.44|P-value:8.30E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.00|P-value:2.10E-8 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.56|P-value:5.76E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.40|P-value:9.62E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.15|P-value:7.44E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.29|P-value:4.41E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.26|P-value:5.05E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.25|P-value:5.75E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.02|P-value:1.20E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-5.89|P-value:3.77E-8 ID:SGTC_2495|Compound:cafestol|FD-Score:3.99|P-value:1.33E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.52|P-value:6.48E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.22|P-value:5.93E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.07|P-value:9.97E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.26|P-value:5.10E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.98|P-value:1.42E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.18|P-value:6.73E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.85|P-value:2.20E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-7.84|P-value:4.02E-13 ID:SGTC_2878|Compound:9043973|FD-Score:-5.53|P-value:2.20E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-3.87|P-value:2.05E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-4.63|P-value:1.19E-5 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.55|P-value:1.60E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-4.00|P-value:1.32E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.89|P-value:1.94E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-4.06|P-value:1.03E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.31|P-value:4.08E-5 ID:SGTC_3212|Compound:9128307|FD-Score:5.14|P-value:1.37E-6 ID:SGTC_3261|Compound:9137475|FD-Score:-3.53|P-value:6.34E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.35|P-value:5.22E-7 ID:SGTC_3346|Compound:9158254|FD-Score:4.22|P-value:5.81E-5 ID:SGTC_3351|Compound:9150312|FD-Score:3.50|P-value:7.03E-4

Top fitness defect scores for YDR322W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.60 5.3 µM 5.91E-31 138 9.83E-37
2 SGTC_275 trichlorophene 9.50 5.7 µM 2.08E-18 mitochondrial stress 53 1.04E-21
3 SGTC_173 1273-0061 9.37 2.7 µM 5.83E-18 mitochondrial stress 47 3.59E-21
4 SGTC_310 1273-0058 7.35 1.1 µM 9.55E-12 mitochondrial stress 108 9.76E-14
5 SGTC_908 3448-7491 6.00 47.7 µM 2.10E-8 mitochondrial stress 48 9.62E-10
6 SGTC_10 0279-0212 5.25 42.6 µM 8.07E-7 TRP & mitochondrial translation 50 7.47E-8
7 SGTC_3212 9128307 5.14 49.5 µM 1.37E-6 26 1.40E-7
8 SGTC_70 0141-0289 4.39 43.3 µM 3.11E-5 mitochondrial stress 145 5.78E-6
9 SGTC_3206 9114350 4.31 49.5 µM 4.08E-5 10 7.99E-6
10 SGTC_1597 7-benzyloxygramine 4.29 47.5 µM 4.41E-5 calcium & mitochondrial duress 100 8.76E-6
11 SGTC_1627 st003713 4.26 25.6 µM 5.05E-5 calcium & mitochondrial duress 59 1.03E-5
12 SGTC_3346 9158254 4.22 43.6 µM 5.81E-5 8 1.22E-5
13 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.22 15.3 µM 5.93E-5 27 1.25E-5
14 SGTC_1371 2421-0008 4.15 32.7 µM 7.44E-5 mitochondrial processes 27 1.63E-5
15 SGTC_386 1509-0011 4.12 3.1 µM 8.54E-5 138 1.92E-5
16 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.07 13.2 µM 9.97E-5 25 2.31E-5
17 SGTC_2250 alverine citrate 4.02 130.0 µM 1.20E-4 149 2.89E-5
18 SGTC_2495 cafestol 3.99 54.5 µM 1.33E-4 Golgi 24 3.25E-5
19 SGTC_118 0083-0097 3.91 135.3 µM 1.78E-4 translation 136 4.60E-5
20 SGTC_3159 9100096 3.89 49.5 µM 1.94E-4 20 5.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.476 1.82E-187 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.475 4.80E-187 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.456 1.36E-170 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.452 9.20E-167 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.433 1.48E-151 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.431 9.44E-151 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.426 1.34E-146 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.421 6.67E-143 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.420 5.82E-142 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.419 2.78E-141 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.416 3.54E-139 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.410 9.44E-135 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.410 9.50E-135 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.409 1.04E-134 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.404 9.60E-131 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci