YDR323C / PEP7

Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR323C / PEP7

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-7.00|P-value:1.20E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:4.21|P-value:9.14E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:9.68|P-value:4.01E-13 ID:SGTC_57|Compound:miconazole|FD-Score:-4.48|P-value:4.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.36|P-value:3.82E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:6.72|P-value:3.20E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:5.92|P-value:5.86E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:12.00|P-value:3.46E-19 ID:SGTC_117|Compound:lucigenin|FD-Score:5.08|P-value:8.44E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.39|P-value:3.27E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.21|P-value:9.03E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:7.28|P-value:3.47E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:7.44|P-value:1.82E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:-5.88|P-value:7.07E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:5.14|P-value:7.10E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:5.62|P-value:1.56E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:5.47|P-value:2.58E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:8.12|P-value:9.34E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:12.30|P-value:5.81E-20 ID:SGTC_206|Compound:4546-0025|FD-Score:10.10|P-value:3.80E-14 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.12|P-value:9.38E-10 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.50|P-value:4.29E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.92|P-value:1.34E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.41|P-value:3.07E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.89|P-value:1.55E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.41|P-value:3.24E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-6.10|P-value:3.31E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:4.54|P-value:3.89E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:16.50|P-value:2.04E-34 ID:SGTC_372|Compound:0155-0182|FD-Score:4.37|P-value:5.96E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:9.85|P-value:1.58E-13 ID:SGTC_439|Compound:amiodarone|FD-Score:6.69|P-value:3.69E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.20|P-value:5.85E-5 ID:SGTC_459|Compound:nigericin|FD-Score:7.11|P-value:7.11E-8 ID:SGTC_470|Compound:aa-861|FD-Score:6.72|P-value:3.27E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:6.70|P-value:3.49E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:8.28|P-value:4.41E-10 ID:SGTC_576|Compound:1073-0113|FD-Score:4.19|P-value:9.47E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:6.39|P-value:1.13E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:4.87|P-value:1.54E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.60|P-value:1.68E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:9.21|P-value:4.75E-12 ID:SGTC_733|Compound:4069-0007|FD-Score:4.68|P-value:2.64E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:14.20|P-value:2.91E-26 ID:SGTC_790|Compound:1575-0012|FD-Score:4.57|P-value:3.53E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:8.96|P-value:1.63E-11 ID:SGTC_824|Compound:1304-0008|FD-Score:5.00|P-value:1.05E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:11.70|P-value:2.32E-18 ID:SGTC_897|Compound:1000-0139|FD-Score:5.19|P-value:6.10E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:6.27|P-value:1.70E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:4.18|P-value:9.80E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-4.44|P-value:5.31E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.62|P-value:1.55E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:8.71|P-value:5.84E-11 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.55|P-value:3.76E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.59|P-value:3.37E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.87|P-value:6.99E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.73|P-value:5.16E-11 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.00|P-value:6.44E-14 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:12.60|P-value:4.66E-21 ID:SGTC_1635|Compound:st007035|FD-Score:4.81|P-value:1.84E-4 ID:SGTC_1658|Compound:st012944|FD-Score:8.85|P-value:2.89E-11 ID:SGTC_1660|Compound:st012960|FD-Score:5.70|P-value:1.21E-5 ID:SGTC_1687|Compound:st020778|FD-Score:16.70|P-value:1.76E-35 ID:SGTC_1711|Compound:st032263|FD-Score:4.84|P-value:1.70E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.50|P-value:2.45E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-6.45|P-value:9.55E-7 ID:SGTC_1754|Compound:st042065|FD-Score:9.40|P-value:1.77E-12 ID:SGTC_1760|Compound:st045453|FD-Score:22.30|P-value:3.32E-61 ID:SGTC_1771|Compound:st048882|FD-Score:7.05|P-value:8.93E-8 ID:SGTC_1773|Compound:st048542|FD-Score:8.53|P-value:1.38E-10 ID:SGTC_1778|Compound:st046819|FD-Score:-4.31|P-value:7.43E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.05|P-value:9.05E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:10.80|P-value:5.37E-16 ID:SGTC_1800|Compound:st050079|FD-Score:5.92|P-value:5.87E-6 ID:SGTC_1801|Compound:st050089|FD-Score:7.54|P-value:1.20E-8 ID:SGTC_1803|Compound:st050068|FD-Score:11.00|P-value:1.76E-16 ID:SGTC_1810|Compound:st050138|FD-Score:4.52|P-value:4.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.51|P-value:4.17E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.47|P-value:1.58E-8 ID:SGTC_1845|Compound:st056753|FD-Score:4.63|P-value:3.02E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.54|P-value:3.89E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.93|P-value:1.28E-4 ID:SGTC_1943|Compound:st076331|FD-Score:5.27|P-value:4.79E-5 ID:SGTC_2029|Compound:5175081|FD-Score:4.68|P-value:2.66E-4 ID:SGTC_2077|Compound:5212015|FD-Score:7.43|P-value:1.93E-8 ID:SGTC_2092|Compound:5303694|FD-Score:5.55|P-value:1.98E-5 ID:SGTC_2099|Compound:5377090|FD-Score:4.50|P-value:4.26E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-4.37|P-value:6.40E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.57|P-value:1.87E-5 ID:SGTC_2242|Compound:6630449|FD-Score:5.06|P-value:8.81E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.97|P-value:1.15E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.01|P-value:1.04E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.49|P-value:4.36E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.89|P-value:6.51E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:5.92|P-value:5.85E-6 ID:SGTC_2526|Compound:patulin|FD-Score:13.50|P-value:6.74E-24 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.90|P-value:5.68E-25 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.77|P-value:2.02E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.80|P-value:1.89E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:10.10|P-value:3.13E-14 ID:SGTC_2619|Compound:obliquin|FD-Score:4.45|P-value:4.90E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.63|P-value:3.04E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.41|P-value:5.49E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.60|P-value:3.24E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.96|P-value:5.14E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.38|P-value:5.84E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:8.94|P-value:1.85E-11 ID:SGTC_2743|Compound:auranofin|FD-Score:6.50|P-value:7.41E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:7.58|P-value:1.01E-8 ID:SGTC_2838|Compound:9002687|FD-Score:-7.70|P-value:6.47E-9 ID:SGTC_2839|Compound:9003951|FD-Score:-5.17|P-value:6.75E-5 ID:SGTC_2851|Compound:9015922|FD-Score:5.58|P-value:1.78E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-4.43|P-value:5.49E-4 ID:SGTC_2921|Compound:7974240|FD-Score:6.03|P-value:3.98E-6 ID:SGTC_2937|Compound:9044753|FD-Score:4.67|P-value:2.69E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.89|P-value:6.43E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-4.70|P-value:2.64E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-4.54|P-value:4.05E-4 ID:SGTC_3041|Compound:9091929|FD-Score:6.88|P-value:1.78E-7 ID:SGTC_3266|Compound:9136860|FD-Score:-6.06|P-value:3.85E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-7.00|P-value:1.20E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:4.21|P-value:9.14E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:9.68|P-value:4.01E-13 ID:SGTC_57|Compound:miconazole|FD-Score:-4.48|P-value:4.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.36|P-value:3.82E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:6.72|P-value:3.20E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:5.92|P-value:5.86E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:12.00|P-value:3.46E-19 ID:SGTC_117|Compound:lucigenin|FD-Score:5.08|P-value:8.44E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.39|P-value:3.27E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.21|P-value:9.03E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:7.28|P-value:3.47E-8 ID:SGTC_131|Compound:0141-0277|FD-Score:7.44|P-value:1.82E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:-5.88|P-value:7.07E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:5.14|P-value:7.10E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:5.62|P-value:1.56E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:5.47|P-value:2.58E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:8.12|P-value:9.34E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:12.30|P-value:5.81E-20 ID:SGTC_206|Compound:4546-0025|FD-Score:10.10|P-value:3.80E-14 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.12|P-value:9.38E-10 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.50|P-value:4.29E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.92|P-value:1.34E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:5.41|P-value:3.07E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.89|P-value:1.55E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.41|P-value:3.24E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:-6.10|P-value:3.31E-6 ID:SGTC_332|Compound:4112-0506|FD-Score:4.54|P-value:3.89E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:16.50|P-value:2.04E-34 ID:SGTC_372|Compound:0155-0182|FD-Score:4.37|P-value:5.96E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:9.85|P-value:1.58E-13 ID:SGTC_439|Compound:amiodarone|FD-Score:6.69|P-value:3.69E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.20|P-value:5.85E-5 ID:SGTC_459|Compound:nigericin|FD-Score:7.11|P-value:7.11E-8 ID:SGTC_470|Compound:aa-861|FD-Score:6.72|P-value:3.27E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:6.70|P-value:3.49E-7 ID:SGTC_528|Compound:3492-0019|FD-Score:8.28|P-value:4.41E-10 ID:SGTC_576|Compound:1073-0113|FD-Score:4.19|P-value:9.47E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:6.39|P-value:1.13E-6 ID:SGTC_612|Compound:0302-0167|FD-Score:4.87|P-value:1.54E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:5.60|P-value:1.68E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:9.21|P-value:4.75E-12 ID:SGTC_733|Compound:4069-0007|FD-Score:4.68|P-value:2.64E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:14.20|P-value:2.91E-26 ID:SGTC_790|Compound:1575-0012|FD-Score:4.57|P-value:3.53E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:8.96|P-value:1.63E-11 ID:SGTC_824|Compound:1304-0008|FD-Score:5.00|P-value:1.05E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:11.70|P-value:2.32E-18 ID:SGTC_897|Compound:1000-0139|FD-Score:5.19|P-value:6.10E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:6.27|P-value:1.70E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:4.18|P-value:9.80E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-4.44|P-value:5.31E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:5.62|P-value:1.55E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:8.71|P-value:5.84E-11 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.55|P-value:3.76E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.59|P-value:3.37E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:5.87|P-value:6.99E-6 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.73|P-value:5.16E-11 ID:SGTC_1495|Compound:4469-0029|FD-Score:10.00|P-value:6.44E-14 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:12.60|P-value:4.66E-21 ID:SGTC_1635|Compound:st007035|FD-Score:4.81|P-value:1.84E-4 ID:SGTC_1658|Compound:st012944|FD-Score:8.85|P-value:2.89E-11 ID:SGTC_1660|Compound:st012960|FD-Score:5.70|P-value:1.21E-5 ID:SGTC_1687|Compound:st020778|FD-Score:16.70|P-value:1.76E-35 ID:SGTC_1711|Compound:st032263|FD-Score:4.84|P-value:1.70E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.50|P-value:2.45E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-6.45|P-value:9.55E-7 ID:SGTC_1754|Compound:st042065|FD-Score:9.40|P-value:1.77E-12 ID:SGTC_1760|Compound:st045453|FD-Score:22.30|P-value:3.32E-61 ID:SGTC_1771|Compound:st048882|FD-Score:7.05|P-value:8.93E-8 ID:SGTC_1773|Compound:st048542|FD-Score:8.53|P-value:1.38E-10 ID:SGTC_1778|Compound:st046819|FD-Score:-4.31|P-value:7.43E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.05|P-value:9.05E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:10.80|P-value:5.37E-16 ID:SGTC_1800|Compound:st050079|FD-Score:5.92|P-value:5.87E-6 ID:SGTC_1801|Compound:st050089|FD-Score:7.54|P-value:1.20E-8 ID:SGTC_1803|Compound:st050068|FD-Score:11.00|P-value:1.76E-16 ID:SGTC_1810|Compound:st050138|FD-Score:4.52|P-value:4.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.51|P-value:4.17E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.47|P-value:1.58E-8 ID:SGTC_1845|Compound:st056753|FD-Score:4.63|P-value:3.02E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.54|P-value:3.89E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.93|P-value:1.28E-4 ID:SGTC_1943|Compound:st076331|FD-Score:5.27|P-value:4.79E-5 ID:SGTC_2029|Compound:5175081|FD-Score:4.68|P-value:2.66E-4 ID:SGTC_2077|Compound:5212015|FD-Score:7.43|P-value:1.93E-8 ID:SGTC_2092|Compound:5303694|FD-Score:5.55|P-value:1.98E-5 ID:SGTC_2099|Compound:5377090|FD-Score:4.50|P-value:4.26E-4 ID:SGTC_2152|Compound:5568786|FD-Score:-4.37|P-value:6.40E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.57|P-value:1.87E-5 ID:SGTC_2242|Compound:6630449|FD-Score:5.06|P-value:8.81E-5 ID:SGTC_2291|Compound:7917025|FD-Score:4.97|P-value:1.15E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.01|P-value:1.04E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.49|P-value:4.36E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.89|P-value:6.51E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:5.92|P-value:5.85E-6 ID:SGTC_2526|Compound:patulin|FD-Score:13.50|P-value:6.74E-24 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:13.90|P-value:5.68E-25 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.77|P-value:2.02E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.80|P-value:1.89E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:10.10|P-value:3.13E-14 ID:SGTC_2619|Compound:obliquin|FD-Score:4.45|P-value:4.90E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.63|P-value:3.04E-4 ID:SGTC_2671|Compound:danthron|FD-Score:4.41|P-value:5.49E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.60|P-value:3.24E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.96|P-value:5.14E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.38|P-value:5.84E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:8.94|P-value:1.85E-11 ID:SGTC_2743|Compound:auranofin|FD-Score:6.50|P-value:7.41E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:7.58|P-value:1.01E-8 ID:SGTC_2838|Compound:9002687|FD-Score:-7.70|P-value:6.47E-9 ID:SGTC_2839|Compound:9003951|FD-Score:-5.17|P-value:6.75E-5 ID:SGTC_2851|Compound:9015922|FD-Score:5.58|P-value:1.78E-5 ID:SGTC_2865|Compound:9030313|FD-Score:-4.43|P-value:5.49E-4 ID:SGTC_2921|Compound:7974240|FD-Score:6.03|P-value:3.98E-6 ID:SGTC_2937|Compound:9044753|FD-Score:4.67|P-value:2.69E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.89|P-value:6.43E-6 ID:SGTC_2997|Compound:9067075|FD-Score:-4.70|P-value:2.64E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-4.54|P-value:4.05E-4 ID:SGTC_3041|Compound:9091929|FD-Score:6.88|P-value:1.78E-7 ID:SGTC_3266|Compound:9136860|FD-Score:-6.06|P-value:3.85E-6

Top fitness defect scores for YDR323C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1760 st045453 22.30 10.4 µM 3.32E-61 NEO1-PIK1 6 4.45E-110
2 SGTC_1687 st020778 16.70 55.4 µM 1.76E-35 15 3.92E-63
3 SGTC_365 0121-0052 16.50 13.6 µM 2.04E-34 mitochondrial response to ROS 2 3.39E-61
4 SGTC_748 0136-0228 14.20 77.9 µM 2.91E-26 redox potentiating 2 2.46E-46
5 SGTC_2567 aureobasidin a 13.90 60.0 nM 5.68E-25 6 5.52E-44
6 SGTC_2526 patulin 13.50 37.6 µM 6.74E-24 6 4.98E-42
7 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 12.60 54.9 µM 4.66E-21 redox potentiating 8 7.32E-37
8 SGTC_168 3970-0862 12.30 530.5 µM 5.81E-20 6 7.21E-35
9 SGTC_70 0141-0289 12.00 43.3 µM 3.46E-19 mitochondrial stress 15 1.85E-33
10 SGTC_841 0251-0215 11.70 91.2 µM 2.32E-18 9 5.87E-32
11 SGTC_1803 st050068 11.00 52.4 µM 1.76E-16 NEO1-PIK1 20 1.53E-28
12 SGTC_1789 tunicamycin 10.80 25.0 nM 5.37E-16 unfolded protein response 5 1.16E-27
13 SGTC_2615 purpurogallin-4-carboxylic acid 10.10 100.0 µM 3.13E-14 redox potentiating 8 1.86E-24
14 SGTC_206 4546-0025 10.10 72.0 µM 3.80E-14 NEO1 13 2.65E-24
15 SGTC_1495 4469-0029 10.00 237.0 µM 6.44E-14 17 6.90E-24
16 SGTC_391 gliotoxin 9.85 8.3 µM 1.58E-13 11 3.53E-23
17 SGTC_52 0329-0193 9.68 875.0 nM 4.01E-13 TSC3-RPN4 2 1.90E-22
18 SGTC_1754 st042065 9.40 16.1 µM 1.77E-12 NEO1-PIK1 33 2.80E-21
19 SGTC_670 4204-0025 9.21 119.0 µM 4.75E-12 copper-dependent oxidative stress 3 1.68E-20
20 SGTC_805 3852-0218 8.96 479.0 µM 1.63E-11 ERAD & cell cycle 6 1.56E-19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.609 0 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.549 1.07E-263 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.496 1.10E-207 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.450 1.30E-166 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
0.399 2.52E-128 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.378 1.41E-114 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.374 7.35E-112 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.371 1.11E-109 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.369 7.24E-109 YPR173C VPS4 hom AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.368 5.87E-108 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.361 7.81E-104 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.360 3.19E-103 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.358 5.22E-102 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
0.350 4.52E-97 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.349 1.23E-96 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p