YDR324C / UTP4

Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR324C / UTP4

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-4.03|P-value:3.94E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.88|P-value:6.05E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.75|P-value:8.54E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.45|P-value:1.03E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.12|P-value:2.96E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.06|P-value:3.54E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.86|P-value:6.48E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.85|P-value:6.65E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.76|P-value:8.15E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.94|P-value:4.92E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.98|P-value:1.58E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.75|P-value:8.81E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.76|P-value:3.39E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:5.95E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.89|P-value:5.99E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.02|P-value:3.87E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.97|P-value:1.62E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.72|P-value:9.20E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.86|P-value:6.45E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.14|P-value:8.69E-6 ID:SGTC_1518|Compound:st038567|FD-Score:5.09|P-value:1.01E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:10.40|P-value:1.68E-18 ID:SGTC_1521|Compound:st012942|FD-Score:5.80|P-value:6.25E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-9.57|P-value:6.66E-16 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.98|P-value:4.51E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.27|P-value:1.75E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.39|P-value:1.19E-4 ID:SGTC_1664|Compound:st014217|FD-Score:-4.81|P-value:3.01E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.80|P-value:2.93E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.22|P-value:2.16E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.79|P-value:7.54E-4 ID:SGTC_1927|Compound:st060202|FD-Score:4.20|P-value:2.23E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.19|P-value:2.26E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.29|P-value:1.65E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.88|P-value:6.10E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.27|P-value:5.43E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-4.81|P-value:3.02E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-3.84|P-value:6.87E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.73|P-value:8.91E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.80|P-value:7.46E-4 ID:SGTC_2303|Compound:7774051|FD-Score:5.18|P-value:7.39E-6 ID:SGTC_2511|Compound:berberine|FD-Score:-5.01|P-value:1.46E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.05|P-value:3.48E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.33|P-value:1.44E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.77|P-value:8.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.34|P-value:4.26E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-5.63|P-value:1.31E-6 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.58|P-value:6.61E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.99|P-value:1.48E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.06|P-value:3.42E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.84|P-value:6.76E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.35|P-value:1.38E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.71|P-value:4.09E-5 ID:SGTC_3047|Compound:9092122|FD-Score:5.92|P-value:3.67E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-11.10|P-value:1.14E-20 ID:SGTC_3071|Compound:9117417|FD-Score:-3.72|P-value:9.53E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-5.37|P-value:3.75E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-5.62|P-value:1.36E-6 ID:SGTC_3118|Compound:9124250|FD-Score:-4.24|P-value:2.06E-4 ID:SGTC_3146|Compound:9095609|FD-Score:7.73|P-value:5.06E-11 ID:SGTC_3222|Compound:9128301|FD-Score:-4.55|P-value:7.34E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.83|P-value:7.06E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.86|P-value:2.56E-5 ID:SGTC_3267|Compound:9137951|FD-Score:5.08|P-value:1.06E-5 ID:SGTC_3268|Compound:9137683|FD-Score:5.09|P-value:1.04E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-4.15|P-value:2.73E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.31|P-value:1.54E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.03|P-value:3.94E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.88|P-value:6.05E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.75|P-value:8.54E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.45|P-value:1.03E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.12|P-value:2.96E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.06|P-value:3.54E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.86|P-value:6.48E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.85|P-value:6.65E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.76|P-value:8.15E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.94|P-value:4.92E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.98|P-value:1.58E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.75|P-value:8.81E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.76|P-value:3.39E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.87|P-value:5.95E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.89|P-value:5.99E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:4.02|P-value:3.87E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.97|P-value:1.62E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.72|P-value:9.20E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.86|P-value:6.45E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:5.14|P-value:8.69E-6 ID:SGTC_1518|Compound:st038567|FD-Score:5.09|P-value:1.01E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:10.40|P-value:1.68E-18 ID:SGTC_1521|Compound:st012942|FD-Score:5.80|P-value:6.25E-7 ID:SGTC_1522|Compound:st012842|FD-Score:-9.57|P-value:6.66E-16 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.98|P-value:4.51E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.27|P-value:1.75E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.39|P-value:1.19E-4 ID:SGTC_1664|Compound:st014217|FD-Score:-4.81|P-value:3.01E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.80|P-value:2.93E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.22|P-value:2.16E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.79|P-value:7.54E-4 ID:SGTC_1927|Compound:st060202|FD-Score:4.20|P-value:2.23E-4 ID:SGTC_1931|Compound:st074438|FD-Score:4.19|P-value:2.26E-4 ID:SGTC_1967|Compound:st070177|FD-Score:4.29|P-value:1.65E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.88|P-value:6.10E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.27|P-value:5.43E-6 ID:SGTC_2082|Compound:5219693|FD-Score:-4.81|P-value:3.02E-5 ID:SGTC_2133|Compound:5320837|FD-Score:-3.84|P-value:6.87E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.73|P-value:8.91E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:3.80|P-value:7.46E-4 ID:SGTC_2303|Compound:7774051|FD-Score:5.18|P-value:7.39E-6 ID:SGTC_2511|Compound:berberine|FD-Score:-5.01|P-value:1.46E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.05|P-value:3.48E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:4.33|P-value:1.44E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.77|P-value:8.40E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.34|P-value:4.26E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-5.63|P-value:1.31E-6 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.58|P-value:6.61E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:4.99|P-value:1.48E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.06|P-value:3.42E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-3.84|P-value:6.76E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.35|P-value:1.38E-4 ID:SGTC_2909|Compound:7941780|FD-Score:4.71|P-value:4.09E-5 ID:SGTC_3047|Compound:9092122|FD-Score:5.92|P-value:3.67E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-11.10|P-value:1.14E-20 ID:SGTC_3071|Compound:9117417|FD-Score:-3.72|P-value:9.53E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-5.37|P-value:3.75E-6 ID:SGTC_3117|Compound:9124945|FD-Score:-5.62|P-value:1.36E-6 ID:SGTC_3118|Compound:9124250|FD-Score:-4.24|P-value:2.06E-4 ID:SGTC_3146|Compound:9095609|FD-Score:7.73|P-value:5.06E-11 ID:SGTC_3222|Compound:9128301|FD-Score:-4.55|P-value:7.34E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-3.83|P-value:7.06E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.86|P-value:2.56E-5 ID:SGTC_3267|Compound:9137951|FD-Score:5.08|P-value:1.06E-5 ID:SGTC_3268|Compound:9137683|FD-Score:5.09|P-value:1.04E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-4.15|P-value:2.73E-4 ID:SGTC_3346|Compound:9158254|FD-Score:4.31|P-value:1.54E-4

Top fitness defect scores for YDR324C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1520 flindersine 10.40 88.0 µM 1.68E-18 1 1.17E-25 2.81
2 SGTC_3146 9095609 7.73 49.5 µM 5.06E-11 1 5.28E-15 3.00
3 SGTC_3047 9092122 5.92 49.5 µM 3.67E-7 1 1.60E-9 0.68
4 SGTC_1521 st012942 5.80 49.4 µM 6.25E-7 2 3.40E-9 0.60
5 SGTC_2303 7774051 5.18 200.0 µM 7.39E-6 1 1.12E-7 0.92
6 SGTC_1363 1636-0063 5.14 10.4 µM 8.69E-6 Golgi 3 1.41E-7 0.64
7 SGTC_1518 st038567 5.09 90.8 µM 1.01E-5 1 1.74E-7 0.82
8 SGTC_3268 9137683 5.09 49.5 µM 1.04E-5 2 1.80E-7 0.25
9 SGTC_3267 9137951 5.08 49.5 µM 1.06E-5 1 1.87E-7 1.02
10 SGTC_2754 granisetron 4.99 64.0 µM 1.48E-5 4 2.98E-7 0.93
11 SGTC_800 3448-7362 4.98 155.0 µM 1.58E-5 translation 32 3.25E-7 0.02
12 SGTC_1116 jasmonic acid 4.97 1.6 µM 1.62E-5 2 3.37E-7 0.44
13 SGTC_1712 st032288 4.80 53.4 µM 2.93E-5 calcium & mitochondrial duress 26 7.82E-7 0.18
14 SGTC_831 k061-1017 4.76 217.0 µM 3.39E-5 translation 3 9.60E-7 0.48
15 SGTC_2909 7941780 4.71 10.5 µM 4.09E-5 2 1.25E-6 0.31
16 SGTC_1652 st011932 4.39 78.0 µM 1.19E-4 RSC complex & mRNA processing 32 5.61E-6 0.14
17 SGTC_2838 9002687 4.35 71.4 µM 1.38E-4 fatty acid desaturase (OLE1) 12 6.93E-6 0.10
18 SGTC_2546 rhodinyl acetate 4.33 100.0 µM 1.44E-4 6 7.33E-6 0.28
19 SGTC_3346 9158254 4.31 43.6 µM 1.54E-4 5 8.10E-6 0.02
20 SGTC_1967 st070177 4.29 51.4 µM 1.65E-4 3 8.87E-6 0.34

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.225 1.02E-39 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.173 5.96E-24 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.168 1.39E-22 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.165 8.07E-22 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.158 2.65E-20 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.154 3.53E-19 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.143 7.42E-17 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.141 2.22E-16 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.141 2.60E-16 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.136 2.38E-15 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.131 2.20E-14 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.130 3.57E-14 YGR128C UTP8 het Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.129 7.77E-14 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.126 2.04E-13 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.123 7.84E-13 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex