YDR325W / YCG1

Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR325W / YCG1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.96|P-value:2.83E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.09|P-value:6.11E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.13|P-value:5.34E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.61|P-value:1.38E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.10|P-value:9.57E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-5.37|P-value:1.24E-8 ID:SGTC_154|Compound:3389-1638|FD-Score:3.12|P-value:8.04E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-6.12|P-value:1.05E-10 ID:SGTC_196|Compound:k015-0023|FD-Score:3.72|P-value:8.03E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.22|P-value:5.63E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-2.98|P-value:9.12E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.25|P-value:3.42E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.47|P-value:2.76E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:4.37|P-value:4.42E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:6.33|P-value:5.31E-11 ID:SGTC_762|Compound:1165-0429|FD-Score:3.09|P-value:8.69E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.01|P-value:2.29E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:4.36|P-value:4.66E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:4.26|P-value:7.51E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:-4.83|P-value:2.58E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.16|P-value:6.83E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.05|P-value:7.04E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.24|P-value:5.13E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.92|P-value:3.38E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.91|P-value:2.89E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.92|P-value:2.20E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.15|P-value:7.24E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.82|P-value:3.37E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.24|P-value:5.15E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.37|P-value:3.17E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.96|P-value:2.90E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.27|P-value:4.65E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.74|P-value:7.20E-5 ID:SGTC_1717|Compound:st033143|FD-Score:7.89|P-value:3.61E-16 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.10|P-value:8.59E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.02|P-value:7.90E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.07|P-value:6.59E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.37|P-value:4.45E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.19|P-value:6.16E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.10|P-value:1.54E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.55|P-value:1.56E-4 ID:SGTC_2328|Compound:6201408|FD-Score:11.40|P-value:5.10E-32 ID:SGTC_2377|Compound:9073351|FD-Score:3.26|P-value:4.77E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.37|P-value:3.21E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.40|P-value:1.95E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.74|P-value:6.84E-7 ID:SGTC_2792|Compound:7535235|FD-Score:4.68|P-value:9.38E-7 ID:SGTC_2795|Compound:7780010|FD-Score:-6.99|P-value:2.19E-13 ID:SGTC_2802|Compound:7925815|FD-Score:-3.50|P-value:1.29E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.09|P-value:6.01E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-5.00|P-value:9.94E-8 ID:SGTC_2917|Compound:7979103|FD-Score:3.29|P-value:4.21E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.75|P-value:4.58E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.32|P-value:2.65E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.14|P-value:5.14E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.12|P-value:7.87E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.52|P-value:2.16E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-4.71|P-value:4.82E-7 ID:SGTC_3351|Compound:9150312|FD-Score:3.13|P-value:7.75E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.96|P-value:2.83E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:-3.09|P-value:6.11E-4 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.13|P-value:5.34E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.61|P-value:1.38E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.10|P-value:9.57E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-5.37|P-value:1.24E-8 ID:SGTC_154|Compound:3389-1638|FD-Score:3.12|P-value:8.04E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-6.12|P-value:1.05E-10 ID:SGTC_196|Compound:k015-0023|FD-Score:3.72|P-value:8.03E-5 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.22|P-value:5.63E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-2.98|P-value:9.12E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.25|P-value:3.42E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:4.47|P-value:2.76E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:4.37|P-value:4.42E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:6.33|P-value:5.31E-11 ID:SGTC_762|Compound:1165-0429|FD-Score:3.09|P-value:8.69E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.01|P-value:2.29E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:4.36|P-value:4.66E-6 ID:SGTC_792|Compound:4534-1957|FD-Score:4.26|P-value:7.51E-6 ID:SGTC_806|Compound:3966-4455|FD-Score:-4.83|P-value:2.58E-7 ID:SGTC_889|Compound:0919-1524|FD-Score:3.60|P-value:1.32E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.16|P-value:6.83E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.05|P-value:7.04E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.24|P-value:5.13E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.92|P-value:3.38E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:4.91|P-value:2.89E-7 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.92|P-value:2.20E-5 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.15|P-value:7.24E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.82|P-value:3.37E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.24|P-value:5.15E-4 ID:SGTC_1620|Compound:st003704|FD-Score:3.37|P-value:3.17E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.96|P-value:2.90E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.27|P-value:4.65E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.74|P-value:7.20E-5 ID:SGTC_1717|Compound:st033143|FD-Score:7.89|P-value:3.61E-16 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.10|P-value:8.59E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.02|P-value:7.90E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-3.07|P-value:6.59E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.37|P-value:4.45E-6 ID:SGTC_2288|Compound:7946289|FD-Score:3.19|P-value:6.16E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.10|P-value:1.54E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.55|P-value:1.56E-4 ID:SGTC_2328|Compound:6201408|FD-Score:11.40|P-value:5.10E-32 ID:SGTC_2377|Compound:9073351|FD-Score:3.26|P-value:4.77E-4 ID:SGTC_2485|Compound:5633444|FD-Score:3.37|P-value:3.21E-4 ID:SGTC_2487|Compound:5918373|FD-Score:-3.40|P-value:1.95E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.74|P-value:6.84E-7 ID:SGTC_2792|Compound:7535235|FD-Score:4.68|P-value:9.38E-7 ID:SGTC_2795|Compound:7780010|FD-Score:-6.99|P-value:2.19E-13 ID:SGTC_2802|Compound:7925815|FD-Score:-3.50|P-value:1.29E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-5.09|P-value:6.01E-8 ID:SGTC_2878|Compound:9043973|FD-Score:-5.00|P-value:9.94E-8 ID:SGTC_2917|Compound:7979103|FD-Score:3.29|P-value:4.21E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.75|P-value:4.58E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-3.32|P-value:2.65E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.14|P-value:5.14E-4 ID:SGTC_3150|Compound:9097574|FD-Score:3.12|P-value:7.87E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.52|P-value:2.16E-6 ID:SGTC_3207|Compound:9114163|FD-Score:-4.71|P-value:4.82E-7 ID:SGTC_3351|Compound:9150312|FD-Score:3.13|P-value:7.75E-4

Top fitness defect scores for YDR325W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2328 6201408 11.40 200.0 µM 5.10E-32 1 1.36E-30 5.11
2 SGTC_1717 st033143 7.89 58.0 µM 3.61E-16 1 1.53E-15 2.35
3 SGTC_761 k216-0224 6.33 480.0 µM 5.31E-11 2 1.26E-10 1.92
4 SGTC_1251 0490-5699 4.91 265.0 µM 2.89E-7 3 4.61E-7 0.17
5 SGTC_2489 cantharidin 4.74 73.4 µM 6.84E-7 cell wall signaling 4 1.05E-6 0.31
6 SGTC_2792 7535235 4.68 81.8 µM 9.38E-7 fatty acid desaturase (OLE1) 5 1.42E-6 0.03
7 SGTC_60 0986-0278 4.61 202.0 µM 1.38E-6 1 2.05E-6 0.77
8 SGTC_3202 9113761 4.52 49.5 µM 2.16E-6 6 3.15E-6 0.15
9 SGTC_734 2023-0417 4.47 80.0 µM 2.76E-6 ergosterol biosynthesis 4 3.98E-6 0.11
10 SGTC_758 0868-0029 4.37 16.0 µM 4.42E-6 1 6.26E-6 1.04
11 SGTC_2275 7947463 4.37 200.0 µM 4.45E-6 iron homeostasis 6 6.30E-6 0.16
12 SGTC_773 4358-1457 4.36 44.6 µM 4.66E-6 8 6.57E-6 0.19
13 SGTC_792 4534-1957 4.26 155.0 µM 7.51E-6 3 1.04E-5 0.08
14 SGTC_2309 7664088 4.10 163.9 µM 1.54E-5 9 2.06E-5 0.04
15 SGTC_763 3453-1109 4.01 128.0 µM 2.29E-5 4 3.02E-5 0.20
16 SGTC_13 0199-0087 3.96 65.0 µM 2.83E-5 ERG2 3 3.70E-5 0.42
17 SGTC_1681 tripelennamine 3.96 100.0 µM 2.90E-5 7 3.79E-5 0.06
18 SGTC_1120 ficusin 3.92 1.8 µM 3.38E-5 3 4.38E-5 0.16
19 SGTC_1686 st019653 3.74 115.5 µM 7.20E-5 mitochondrial processes 4 9.05E-5 0.03
20 SGTC_196 k015-0023 3.72 18.1 µM 8.03E-5 PDR1 2 1.00E-4 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.19E-19 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.155 2.14E-19 YDR384C ATO3 hom Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
0.134 7.39E-15 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.133 1.06E-14 YJL010C NOP9 het Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.126 3.09E-13 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.123 1.18E-12 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.111 1.13E-10 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.110 1.90E-10 YCR007C_p YCR007C_p hom Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.109 2.76E-10 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.108 3.33E-10 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.104 1.94E-9 YDR291W HRQ1 hom 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.098 1.26E-8 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.097 1.78E-8 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.092 9.06E-8 YDR194W-A_p YDR194W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.092 9.59E-8 YPL023C MET12 hom Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR