YDR326C / YSP2

Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR326C / YSP2

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:5.24|P-value:1.58E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:11.40|P-value:6.12E-29 ID:SGTC_142|Compound:0335-0849|FD-Score:8.77|P-value:5.80E-18 ID:SGTC_165|Compound:k038-0023|FD-Score:3.95|P-value:5.86E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.72|P-value:1.45E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:16.10|P-value:8.53E-56 ID:SGTC_352|Compound:k048-0007|FD-Score:3.89|P-value:7.48E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.78|P-value:1.54E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:3.59|P-value:2.29E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.96|P-value:5.60E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.69|P-value:1.59E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.42|P-value:4.32E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.83|P-value:1.20E-6 ID:SGTC_470|Compound:aa-861|FD-Score:8.98|P-value:9.87E-19 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.53|P-value:2.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.73|P-value:1.94E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:4.90|P-value:8.88E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:5.06|P-value:3.94E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:5.31|P-value:1.14E-7 ID:SGTC_642|Compound:0335-0876|FD-Score:3.91|P-value:6.95E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:5.57|P-value:2.81E-8 ID:SGTC_683|Compound:panaxydol|FD-Score:7.05|P-value:2.95E-12 ID:SGTC_779|Compound:1360-0071|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.22|P-value:8.33E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.86|P-value:5.29E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:3.64|P-value:1.96E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.21|P-value:2.02E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.55|P-value:2.67E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.45|P-value:3.76E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.68|P-value:3.49E-11 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.74|P-value:1.85E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.61|P-value:2.15E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.80|P-value:1.06E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.22|P-value:1.92E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.29|P-value:6.58E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.95|P-value:5.81E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:5.00|P-value:5.32E-7 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.29|P-value:6.79E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:12.90|P-value:1.44E-36 ID:SGTC_1685|Compound:st024049|FD-Score:4.57|P-value:4.13E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.40|P-value:8.72E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:9.40|P-value:2.29E-20 ID:SGTC_1904|Compound:st060225|FD-Score:3.74|P-value:1.32E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.25|P-value:7.53E-4 ID:SGTC_1941|Compound:st076221|FD-Score:12.60|P-value:4.49E-35 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.06|P-value:3.69E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-3.28|P-value:6.75E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.49|P-value:3.27E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.77|P-value:1.20E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.96|P-value:6.54E-7 ID:SGTC_2438|Compound:5259590|FD-Score:-3.44|P-value:3.83E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.25|P-value:7.52E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.16|P-value:2.43E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.10|P-value:3.07E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.95|P-value:6.96E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.93|P-value:5.09E-15 ID:SGTC_2645|Compound:abamectin|FD-Score:3.76|P-value:1.25E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.68|P-value:1.69E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.74|P-value:1.33E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.29|P-value:6.73E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.25|P-value:1.73E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.70|P-value:1.56E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.69|P-value:1.58E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.03|P-value:4.24E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.19|P-value:2.04E-7 ID:SGTC_3332|Compound:9141069|FD-Score:4.18|P-value:2.24E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:5.24|P-value:1.58E-7 ID:SGTC_137|Compound:0438-0332|FD-Score:11.40|P-value:6.12E-29 ID:SGTC_142|Compound:0335-0849|FD-Score:8.77|P-value:5.80E-18 ID:SGTC_165|Compound:k038-0023|FD-Score:3.95|P-value:5.86E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.72|P-value:1.45E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:16.10|P-value:8.53E-56 ID:SGTC_352|Compound:k048-0007|FD-Score:3.89|P-value:7.48E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:4.78|P-value:1.54E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:3.59|P-value:2.29E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.96|P-value:5.60E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.69|P-value:1.59E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.42|P-value:4.32E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.83|P-value:1.20E-6 ID:SGTC_470|Compound:aa-861|FD-Score:8.98|P-value:9.87E-19 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.53|P-value:2.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.73|P-value:1.94E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:4.90|P-value:8.88E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:5.06|P-value:3.94E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:5.31|P-value:1.14E-7 ID:SGTC_642|Compound:0335-0876|FD-Score:3.91|P-value:6.95E-5 ID:SGTC_664|Compound:1222-0054|FD-Score:5.57|P-value:2.81E-8 ID:SGTC_683|Compound:panaxydol|FD-Score:7.05|P-value:2.95E-12 ID:SGTC_779|Compound:1360-0071|FD-Score:3.75|P-value:1.26E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.22|P-value:8.33E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.86|P-value:5.29E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:3.64|P-value:1.96E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:4.21|P-value:2.02E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.42|P-value:4.22E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.55|P-value:2.67E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.45|P-value:3.76E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.68|P-value:3.49E-11 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.74|P-value:1.85E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.61|P-value:2.15E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.80|P-value:1.06E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:4.22|P-value:1.92E-5 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.29|P-value:6.58E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.95|P-value:5.81E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:5.00|P-value:5.32E-7 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.29|P-value:6.79E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:12.90|P-value:1.44E-36 ID:SGTC_1685|Compound:st024049|FD-Score:4.57|P-value:4.13E-6 ID:SGTC_1712|Compound:st032288|FD-Score:-4.40|P-value:8.72E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:9.40|P-value:2.29E-20 ID:SGTC_1904|Compound:st060225|FD-Score:3.74|P-value:1.32E-4 ID:SGTC_1931|Compound:st074438|FD-Score:3.25|P-value:7.53E-4 ID:SGTC_1941|Compound:st076221|FD-Score:12.60|P-value:4.49E-35 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-4.06|P-value:3.69E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-3.28|P-value:6.75E-4 ID:SGTC_2104|Compound:5389443|FD-Score:-3.49|P-value:3.27E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.77|P-value:1.20E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.96|P-value:6.54E-7 ID:SGTC_2438|Compound:5259590|FD-Score:-3.44|P-value:3.83E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-3.25|P-value:7.52E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.16|P-value:2.43E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-4.10|P-value:3.07E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:4.95|P-value:6.96E-7 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.93|P-value:5.09E-15 ID:SGTC_2645|Compound:abamectin|FD-Score:3.76|P-value:1.25E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.68|P-value:1.69E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.74|P-value:1.33E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.29|P-value:6.73E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.25|P-value:1.73E-5 ID:SGTC_3098|Compound:9119039|FD-Score:3.70|P-value:1.56E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.69|P-value:1.58E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.03|P-value:4.24E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.19|P-value:2.04E-7 ID:SGTC_3332|Compound:9141069|FD-Score:4.18|P-value:2.24E-5

Top fitness defect scores for YDR326C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_266 formosanin C 16.10 406.0 nM 8.53E-56 sphingolipid biosynthesis & PDR1 7 1.77E-58
2 SGTC_1568 digitonin 12.90 820.0 nM 1.44E-36 sphingolipid biosynthesis & PDR1 6 2.67E-38
3 SGTC_1941 st076221 12.60 61.8 µM 4.49E-35 sphingolipid biosynthesis & PDR1 6 9.91E-37
4 SGTC_137 0438-0332 11.40 85.4 µM 6.12E-29 ubiquinone biosynthesis & proteasome 21 2.71E-30
5 SGTC_1872 amphotericin b 9.40 148.0 nM 2.29E-20 RNA pol III & RNase P/MRP 3 2.69E-21
6 SGTC_470 aa-861 8.98 153.0 µM 9.87E-19 sphingolipid biosynthesis & PDR1 14 1.40E-19
7 SGTC_142 0335-0849 8.77 62.7 µM 5.80E-18 ubiquinone biosynthesis & proteasome 39 8.96E-19
8 SGTC_2582 agaric acid 7.93 100.0 µM 5.09E-15 redox potentiating 104 1.10E-15
9 SGTC_683 panaxydol 7.05 45.0 µM 2.95E-12 sphingolipid biosynthesis & PDR1 9 8.69E-13
10 SGTC_1277 0873-0036 6.68 22.0 µM 3.49E-11 PDR1 3 1.16E-11
11 SGTC_794 k038-0031 5.86 316.0 µM 5.29E-9 ubiquinone biosynthesis & proteasome 58 2.25E-9
12 SGTC_664 1222-0054 5.57 14.9 µM 2.81E-8 sphingolipid biosynthesis & PDR1 21 1.30E-8
13 SGTC_628 1636-0253 5.31 16.0 µM 1.14E-7 sphingolipid biosynthesis & PDR1 13 5.61E-8
14 SGTC_86 0417-1630 5.24 471.9 µM 1.58E-7 ubiquinone biosynthesis & proteasome 107 7.94E-8
15 SGTC_3311 9131146 5.19 2.9 µM 2.04E-7 cell wall 79 1.04E-7
16 SGTC_588 3970-1144 5.06 52.9 µM 3.94E-7 10 2.06E-7
17 SGTC_1423 4048-0112 5.00 5.6 µM 5.32E-7 13 2.83E-7
18 SGTC_2312 7706453 4.96 155.7 µM 6.54E-7 14 3.51E-7
19 SGTC_2581 avocatin a 4.95 64.0 µM 6.96E-7 sphingolipid biosynthesis & PDR1 34 3.75E-7
20 SGTC_548 1436-0017 4.90 110.0 µM 8.88E-7 TSC3-RPN4 24 4.85E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.629 0 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.361 1.08E-103 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.343 2.34E-93 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.333 1.15E-87 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.318 7.94E-80 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.244 1.68E-46 YPL056C_p LCL1_p hom Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan
0.238 1.77E-44 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.238 2.07E-44 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.237 7.02E-44 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.236 8.26E-44 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.233 1.50E-42 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.227 1.54E-40 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.213 1.40E-35 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.211 5.72E-35 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.206 1.34E-33 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family