YDR329C / PEX3

Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR329C / PEX3

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.54|P-value:2.29E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.34|P-value:5.08E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:15.10|P-value:2.70E-50 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.20|P-value:7.65E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.25|P-value:6.88E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.57|P-value:3.47E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:5.68|P-value:1.13E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.32|P-value:5.09E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.93|P-value:5.58E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:3.15|P-value:9.89E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.56|P-value:2.32E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.55|P-value:2.23E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.60|P-value:2.00E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.24|P-value:7.14E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.06|P-value:3.26E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.96|P-value:4.81E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.58|P-value:2.18E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.46|P-value:3.03E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.56|P-value:3.58E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:3.81|P-value:9.01E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.22|P-value:7.68E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.43|P-value:3.67E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.42|P-value:3.52E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.38|P-value:4.44E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.72|P-value:9.00E-9 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-4.14|P-value:2.15E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.29|P-value:6.05E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.57|P-value:2.05E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.68|P-value:2.04E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.79|P-value:9.76E-5 ID:SGTC_1732|Compound:st034308|FD-Score:4.05|P-value:3.31E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.12|P-value:2.56E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.63|P-value:1.66E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.27|P-value:6.42E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.39|P-value:3.97E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.95|P-value:5.62E-7 ID:SGTC_2051|Compound:5263410|FD-Score:-3.44|P-value:3.34E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.26|P-value:1.24E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-3.39|P-value:3.99E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.19|P-value:1.61E-7 ID:SGTC_2223|Compound:6903751|FD-Score:3.31|P-value:5.70E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.54|P-value:4.00E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.09|P-value:2.81E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.71|P-value:1.22E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.29|P-value:1.12E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.40|P-value:6.71E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:5.30|P-value:9.11E-8 ID:SGTC_2807|Compound:7945238|FD-Score:3.54|P-value:2.48E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.24|P-value:6.64E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.19|P-value:8.41E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.18|P-value:8.71E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.86|P-value:7.35E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-5.67|P-value:1.06E-8 ID:SGTC_3289|Compound:9119912|FD-Score:3.38|P-value:4.39E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.29|P-value:6.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.54|P-value:2.29E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:3.34|P-value:5.08E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:15.10|P-value:2.70E-50 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.20|P-value:7.65E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.25|P-value:6.88E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.57|P-value:3.47E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:5.68|P-value:1.13E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.32|P-value:5.09E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:3.93|P-value:5.58E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:3.15|P-value:9.89E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.56|P-value:2.32E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.55|P-value:2.23E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.60|P-value:2.00E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.24|P-value:7.14E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.06|P-value:3.26E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.96|P-value:4.81E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.58|P-value:2.18E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.46|P-value:3.03E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.56|P-value:3.58E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:3.81|P-value:9.01E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:3.22|P-value:7.68E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.43|P-value:3.67E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.42|P-value:3.52E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.38|P-value:4.44E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.72|P-value:9.00E-9 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-4.14|P-value:2.15E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.29|P-value:6.05E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.57|P-value:2.05E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.68|P-value:2.04E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.79|P-value:9.76E-5 ID:SGTC_1732|Compound:st034308|FD-Score:4.05|P-value:3.31E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.12|P-value:2.56E-5 ID:SGTC_1822|Compound:st052468|FD-Score:-3.63|P-value:1.66E-4 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.27|P-value:6.42E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:-3.39|P-value:3.97E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.95|P-value:5.62E-7 ID:SGTC_2051|Compound:5263410|FD-Score:-3.44|P-value:3.34E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.26|P-value:1.24E-5 ID:SGTC_2055|Compound:5235184|FD-Score:-3.39|P-value:3.99E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.19|P-value:1.61E-7 ID:SGTC_2223|Compound:6903751|FD-Score:3.31|P-value:5.70E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.54|P-value:4.00E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.09|P-value:2.81E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.71|P-value:1.22E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-4.29|P-value:1.12E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-4.40|P-value:6.71E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:5.30|P-value:9.11E-8 ID:SGTC_2807|Compound:7945238|FD-Score:3.54|P-value:2.48E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.24|P-value:6.64E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.19|P-value:8.41E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.55|P-value:2.40E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.18|P-value:8.71E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.86|P-value:7.35E-5 ID:SGTC_3288|Compound:9119690|FD-Score:-5.67|P-value:1.06E-8 ID:SGTC_3289|Compound:9119912|FD-Score:3.38|P-value:4.39E-4

Top fitness defect scores for YDR329C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_68 0986-0284 15.10 82.8 µM 2.70E-50 3 1.11E-51
2 SGTC_922 1866-0035 5.72 480.0 µM 9.00E-9 excess fatty acid 21 5.41E-9
3 SGTC_131 0141-0277 5.68 33.9 µM 1.13E-8 9 6.81E-9
4 SGTC_2754 granisetron 5.30 64.0 µM 9.11E-8 15 5.85E-8
5 SGTC_2056 5235370 5.19 200.0 µM 1.61E-7 21 1.05E-7
6 SGTC_1926 methyl fluorone black 4.95 53.6 µM 5.62E-7 DNA intercalators 36 3.80E-7
7 SGTC_1255 0566-0045 4.68 221.0 µM 2.04E-6 excess fatty acid 13 1.43E-6
8 SGTC_128 0906-2981 4.57 13.4 µM 3.47E-6 7 2.47E-6
9 SGTC_690 glyoxal 4.56 20.3 µM 3.58E-6 65 2.55E-6
10 SGTC_2322 7413319 4.54 38.2 µM 4.00E-6 ERAD & cell cycle 125 2.86E-6
11 SGTC_1818 st052136 4.12 56.3 µM 2.56E-5 NEO1-PIK1 42 1.93E-5
12 SGTC_2598 perillyl alcohol 4.09 100.0 µM 2.81E-5 26 2.12E-5
13 SGTC_453 enantio-paf c16 4.06 10.0 µM 3.26E-5 135 2.48E-5
14 SGTC_1732 st034308 4.05 51.8 µM 3.31E-5 23 2.51E-5
15 SGTC_457 grayanotoxin iii 3.96 135.0 µM 4.81E-5 65 3.69E-5
16 SGTC_169 k015-0017 3.93 16.0 µM 5.58E-5 20 4.30E-5
17 SGTC_3155 9099265 3.86 49.5 µM 7.35E-5 24 5.70E-5
18 SGTC_780 0109-0199 3.81 192.0 µM 9.01E-5 17 7.03E-5
19 SGTC_1712 st032288 3.79 53.4 µM 9.76E-5 calcium & mitochondrial duress 199 7.64E-5
20 SGTC_426 0988-0037 3.65 14.6 µM 1.67E-4 ERAD & cell cycle 44 1.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 8.45E-18 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.139 7.32E-16 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.138 1.19E-15 YHR085W IPI1 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene
0.128 8.46E-14 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.125 3.82E-13 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.120 2.48E-12 YML028W TSA1 hom Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.113 4.91E-11 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.111 1.02E-10 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.110 1.52E-10 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.108 3.28E-10 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.107 5.98E-10 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.103 2.30E-9 YOL038C-A_p YOL038C-A_p hom Putative protein of unknown function; identified by SAGE analysis
0.102 2.72E-9 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.100 7.11E-9 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.099 8.24E-9 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability