HIPHOP chemogenomics database

YDR334W / SWR1

Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR334W / SWR1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR334W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2319	6033012	22.00	152.6 µM	4.22E-79	tubulin folding & SWR complex	3	3.47E-107
2	SGTC_2174	5790901	21.50	200.0 µM	4.30E-76	tubulin folding & SWR complex	3	4.40E-103
3	SGTC_221	trifluoperazine	16.50	10.3 µM	1.72E-45	NEO1-PIK1	18	2.32E-61
4	SGTC_210	3551-0445	14.40	56.8 µM	3.72E-35		9	2.81E-47
5	SGTC_2200	6600604	13.30	21.9 µM	4.27E-30	tubulin folding & SWR complex	7	2.21E-40
6	SGTC_1875	nocodazole	12.50	6.0 µM	5.44E-27	tubulin folding & SWR complex	9	3.75E-36
7	SGTC_1803	st050068	12.20	52.4 µM	1.31E-25	NEO1-PIK1	13	2.85E-34
8	SGTC_1326	1431-2094	11.60	10.8 µM	1.35E-23	tubulin folding & SWR complex	4	1.57E-31
9	SGTC_212	3807-4682	11.20	38.8 µM	3.85E-22	tubulin folding & SWR complex	5	1.51E-29
10	SGTC_142	0335-0849	10.20	62.7 µM	1.80E-18	ubiquinone biosynthesis & proteasome	27	1.49E-24
11	SGTC_673	1082-0474	9.72	110.0 µM	4.77E-17	RSC complex & mRNA processing	9	1.29E-22
12	SGTC_2166	5933061	9.55	31.5 µM	1.55E-16	tubulin folding & SWR complex	3	6.41E-22
13	SGTC_2141	5621638	9.45	7.7 µM	3.10E-16	tubulin folding & SWR complex	7	1.65E-21
14	SGTC_825	1988-2224	9.40	89.6 µM	4.38E-16	cell wall signaling	6	2.63E-21
15	SGTC_229	benomyl	8.88	22.9 µM	1.55E-14	tubulin folding & SWR complex	11	3.35E-19
16	SGTC_1643	st009866	8.87	20.2 µM	1.62E-14		12	3.58E-19
17	SGTC_1754	st042065	8.53	16.1 µM	1.45E-13	NEO1-PIK1	49	7.04E-18
18	SGTC_528	3492-0019	8.35	172.0 µM	4.71E-13	calcium & mitochondrial duress	64	3.49E-17
19	SGTC_2246	7293507	8.28	91.6 µM	7.10E-13		6	6.08E-17
20	SGTC_1801	st050089	8.20	28.4 µM	1.18E-12	NEO1-PIK1	24	1.21E-16

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.672	0	YLR085C	ARP6	hom	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.663	0	YML041C	VPS71	hom	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.614	0	YAL011W	SWC3	hom	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.608	0	YDR485C	VPS72	hom	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.567	3.33E-285	YBR231C	SWC5	hom	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.523	1.08E-234	YER007W	PAC2	hom	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.451	6.02E-168	YML124C	TUB3	hom	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.421	2.99E-144	YOR349W	CIN1	hom	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.416	1.56E-140	YOL012C	HTZ1	hom	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
0.386	9.74E-120	YPL241C	CIN2	hom	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.322	7.08E-82	YGL094C	PAN2	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.318	6.03E-80	YKL025C	PAN3	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.263	3.31E-54	YLR020C	YEH2	hom	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.253	3.24E-50	YNL246W	VPS75	hom	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.252	6.91E-50	YNL107W	YAF9	hom	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain