YDR336W_p

Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR336W / YDR336W

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.36|P-value:6.01E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.20|P-value:9.63E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.35|P-value:1.39E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.49|P-value:3.92E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:5.79|P-value:1.19E-8 ID:SGTC_530|Compound:4358-1714|FD-Score:5.05|P-value:5.81E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:5.88|P-value:7.08E-9 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.28|P-value:1.73E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.31|P-value:7.32E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.66|P-value:2.14E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.46|P-value:4.33E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:7.49|P-value:2.62E-13 ID:SGTC_973|Compound:1325-0077|FD-Score:3.50|P-value:3.82E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.36|P-value:5.63E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.84|P-value:1.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.66|P-value:1.99E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.71|P-value:1.62E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.88|P-value:8.54E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.53|P-value:3.39E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.72|P-value:1.56E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.54|P-value:3.23E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.43|P-value:4.38E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.37|P-value:5.38E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.51|P-value:5.34E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.22|P-value:8.87E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.24|P-value:2.18E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.11|P-value:3.75E-5 ID:SGTC_2462|Compound:5162487|FD-Score:5.08|P-value:4.83E-7 ID:SGTC_2472|Compound:5377652|FD-Score:4.01|P-value:5.56E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.66|P-value:1.97E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.04|P-value:4.95E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.44|P-value:4.61E-4 ID:SGTC_2890|Compound:9046729|FD-Score:4.12|P-value:3.68E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.64|P-value:2.31E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.81|P-value:1.22E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.36|P-value:6.01E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.20|P-value:9.63E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.35|P-value:1.39E-5 ID:SGTC_228|Compound:caffeine|FD-Score:3.49|P-value:3.92E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:5.79|P-value:1.19E-8 ID:SGTC_530|Compound:4358-1714|FD-Score:5.05|P-value:5.81E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:5.88|P-value:7.08E-9 ID:SGTC_536|Compound:3852-0578|FD-Score:-4.28|P-value:1.73E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.31|P-value:7.32E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.66|P-value:2.14E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.46|P-value:4.33E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:7.49|P-value:2.62E-13 ID:SGTC_973|Compound:1325-0077|FD-Score:3.50|P-value:3.82E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.36|P-value:5.63E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.84|P-value:1.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.66|P-value:1.99E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.71|P-value:1.62E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.88|P-value:8.54E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.53|P-value:3.39E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.72|P-value:1.56E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.54|P-value:3.23E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.43|P-value:4.38E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.37|P-value:5.38E-4 ID:SGTC_2275|Compound:7947463|FD-Score:5.51|P-value:5.34E-8 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.22|P-value:8.87E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.24|P-value:2.18E-5 ID:SGTC_2416|Compound:tofa|FD-Score:4.11|P-value:3.75E-5 ID:SGTC_2462|Compound:5162487|FD-Score:5.08|P-value:4.83E-7 ID:SGTC_2472|Compound:5377652|FD-Score:4.01|P-value:5.56E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.66|P-value:1.97E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.04|P-value:4.95E-5 ID:SGTC_2884|Compound:9058502|FD-Score:3.44|P-value:4.61E-4 ID:SGTC_2890|Compound:9046729|FD-Score:4.12|P-value:3.68E-5 ID:SGTC_2970|Compound:9090938|FD-Score:3.64|P-value:2.31E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.81|P-value:1.22E-4

Top fitness defect scores for YDR336W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_972 1319-0219 7.49 195.0 µM 2.62E-13 4 3.58E-14
2 SGTC_535 2293-4129 5.88 48.2 µM 7.08E-9 NEO1 28 2.01E-9
3 SGTC_438 sphingosine 5.79 6.7 µM 1.19E-8 6 3.52E-9
4 SGTC_2275 7947463 5.51 200.0 µM 5.34E-8 iron homeostasis 14 1.76E-8
5 SGTC_2462 5162487 5.08 171.8 µM 4.83E-7 10 1.86E-7
6 SGTC_530 4358-1714 5.05 28.0 µM 5.81E-7 15 2.27E-7
7 SGTC_219 mitoxanthrone 4.35 164.4 µM 1.39E-5 DNA intercalators 43 6.79E-6
8 SGTC_2409 alverine citrate 4.24 64.0 µM 2.18E-5 47 1.10E-5
9 SGTC_2890 9046729 4.12 58.4 µM 3.68E-5 Golgi 19 1.93E-5
10 SGTC_2416 tofa 4.11 880.0 nM 3.75E-5 sphingolipid biosynthesis & PDR1 45 1.97E-5
11 SGTC_2805 7950783 4.04 58.4 µM 4.95E-5 29 2.65E-5
12 SGTC_2472 5377652 4.01 49.4 µM 5.56E-5 TRP & mitochondrial translation 53 3.00E-5
13 SGTC_1128 3448-9350 3.84 235.0 µM 1.08E-4 25 6.13E-5
14 SGTC_3201 9113999 3.81 49.5 µM 1.22E-4 38 6.99E-5
15 SGTC_729 4092-0585 3.66 94.1 µM 2.14E-4 32 1.27E-4
16 SGTC_2970 9090938 3.64 41.9 µM 2.31E-4 RNA processing & uracil transport 56 1.38E-4
17 SGTC_1831 st055328 3.54 12.0 µM 3.23E-4 heme biosynthesis & mitochondrial translocase 40 1.98E-4
18 SGTC_1716 st033144 3.53 30.6 µM 3.39E-4 31 2.08E-4
19 SGTC_973 1325-0077 3.50 65.9 µM 3.82E-4 20 2.36E-4
20 SGTC_228 caffeine 3.49 993.1 µM 3.92E-4 17 2.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.25E-28 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.135 3.97E-15 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.133 1.25E-14 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.103 2.20E-9 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.100 6.30E-9 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.099 9.43E-9 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.095 4.04E-8 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.090 1.78E-7 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 2.96E-7 YKL096W CWP1 hom Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
0.085 7.90E-7 YJL137C GLG2 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.084 1.17E-6 YIL127C_p RRT14_p hom Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.084 1.23E-6 YPL188W POS5 hom Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress
0.084 1.29E-6 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.083 1.73E-6 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.079 4.83E-6 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA