YDR338C_p

Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR338C / YDR338C

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:-4.03|P-value:6.26E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.33|P-value:9.41E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.39|P-value:7.94E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.34|P-value:2.90E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:3.45|P-value:6.42E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.55|P-value:4.68E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.49|P-value:5.70E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.44|P-value:1.67E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.48|P-value:1.38E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.40|P-value:1.94E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.28|P-value:8.74E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.98|P-value:7.65E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.64|P-value:3.44E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.82|P-value:1.79E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.60|P-value:3.95E-4 ID:SGTC_1794|Compound:st048918|FD-Score:4.52|P-value:1.19E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.46|P-value:6.17E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.93|P-value:1.20E-4 ID:SGTC_2123|Compound:5259487|FD-Score:5.61|P-value:7.53E-8 ID:SGTC_2173|Compound:5763948|FD-Score:-3.63|P-value:2.74E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.00|P-value:9.49E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.52|P-value:5.11E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.42|P-value:5.60E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.25|P-value:9.78E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-4.03|P-value:6.26E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.33|P-value:9.41E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.39|P-value:7.94E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.34|P-value:2.90E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:3.45|P-value:6.42E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.55|P-value:4.68E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.49|P-value:5.70E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.44|P-value:1.67E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:4.48|P-value:1.38E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.40|P-value:1.94E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.28|P-value:8.74E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.98|P-value:7.65E-5 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.64|P-value:3.44E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.82|P-value:1.79E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.60|P-value:3.95E-4 ID:SGTC_1794|Compound:st048918|FD-Score:4.52|P-value:1.19E-5 ID:SGTC_1940|Compound:st075990|FD-Score:3.46|P-value:6.17E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.93|P-value:1.20E-4 ID:SGTC_2123|Compound:5259487|FD-Score:5.61|P-value:7.53E-8 ID:SGTC_2173|Compound:5763948|FD-Score:-3.63|P-value:2.74E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.00|P-value:9.49E-5 ID:SGTC_2438|Compound:5259590|FD-Score:3.52|P-value:5.11E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.42|P-value:5.60E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.25|P-value:9.78E-4

Top fitness defect scores for YDR338C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2123 5259487 5.61 200.0 µM 7.53E-8 5 1.03E-8
2 SGTC_365 0121-0052 5.34 13.6 µM 2.90E-7 mitochondrial response to ROS 22 4.72E-8
3 SGTC_1794 st048918 4.52 76.9 µM 1.19E-5 7 3.11E-6
4 SGTC_1110 3-hydroxy-3'-methoxyflavone 4.48 1.2 µM 1.38E-5 iron homeostasis 31 3.67E-6
5 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.44 15.5 µM 1.67E-5 16 4.56E-6
6 SGTC_1112 tnp00069 4.40 1.2 µM 1.94E-5 15 5.38E-6
7 SGTC_2247 cerulenin 4.00 830.0 nM 9.49E-5 15 3.23E-5
8 SGTC_1968 st069590 3.93 43.6 µM 1.20E-4 15 4.22E-5
9 SGTC_1350 1495-0454 3.82 146.0 µM 1.79E-4 33 6.61E-5
10 SGTC_1281 0884-0031 3.64 11.8 µM 3.44E-4 fatty acid desaturase (OLE1) 28 1.38E-4
11 SGTC_1364 1653-0028 3.60 37.6 µM 3.95E-4 37 1.61E-4
12 SGTC_1011 4112-3381 3.55 17.4 µM 4.68E-4 57 1.95E-4
13 SGTC_2438 5259590 3.52 200.0 µM 5.11E-4 23 2.15E-4
14 SGTC_1091 telmisartan 3.49 47.6 µM 5.70E-4 30 2.43E-4
15 SGTC_1940 st075990 3.46 51.1 µM 6.17E-4 60S ribosome export 35 2.66E-4
16 SGTC_747 3448-8087 3.45 38.7 µM 6.42E-4 42 2.78E-4
17 SGTC_326 k292-0812 3.39 17.5 µM 7.94E-4 13 3.53E-4
18 SGTC_172 1112-0046 3.33 2.6 µM 9.41E-4 NEO1 58 4.28E-4
19 SGTC_798 1287-0182 3.31 476.0 µM 0.00103 49 4.73E-4
20 SGTC_1100 amiodarone 3.22 5.1 µM 0.00134 41 6.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.14E-10 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.095 3.24E-8 YLR248W RCK2 hom Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication
0.089 2.45E-7 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.084 1.03E-6 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.082 2.10E-6 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.080 3.59E-6 YDR391C_p YDR391C_p hom Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.080 3.72E-6 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.080 3.93E-6 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.079 4.58E-6 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.079 4.74E-6 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.079 5.20E-6 YKL059C MPE1 het Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
0.077 7.35E-6 YHR105W YPT35 hom Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
0.075 1.33E-5 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
0.075 1.34E-5 YHR101C BIG1 het Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
0.074 1.84E-5 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function