YDR339C / FCF1

Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR339C / FCF1

Click on Significant Values for Screen Details ID:SGTC_323|Compound:4013-0906|FD-Score:2.57|P-value:8.92E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:2.77|P-value:3.92E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.59|P-value:8.45E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.14|P-value:8.56E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:5.01|P-value:6.82E-10 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.16|P-value:6.52E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:2.97|P-value:1.55E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.60|P-value:9.39E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-5.28|P-value:1.21E-10 ID:SGTC_669|Compound:0108-0021|FD-Score:3.66|P-value:4.55E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:4.11|P-value:3.34E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.42|P-value:1.75E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.82|P-value:3.06E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:2.77|P-value:3.86E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.87|P-value:6.46E-13 ID:SGTC_1017|Compound:4239-0030|FD-Score:-2.67|P-value:7.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.77|P-value:3.20E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:2.80|P-value:3.45E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.66|P-value:6.32E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.23|P-value:5.63E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.61|P-value:7.54E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.34|P-value:2.62E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.08|P-value:9.49E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.29|P-value:4.09E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.83|P-value:2.97E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.38|P-value:2.08E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.21|P-value:6.20E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.92|P-value:1.98E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.72|P-value:5.75E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:2.57|P-value:9.05E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-2.61|P-value:9.10E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.64|P-value:6.71E-4 ID:SGTC_1946|Compound:st076057|FD-Score:2.71|P-value:5.02E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.24|P-value:5.29E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.69|P-value:4.04E-6 ID:SGTC_2201|Compound:6605497|FD-Score:2.92|P-value:1.99E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.01|P-value:1.31E-4 ID:SGTC_2258|Compound:7960471|FD-Score:2.79|P-value:3.53E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.29|P-value:3.41E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.26|P-value:4.83E-5 ID:SGTC_2368|Compound:9071271|FD-Score:2.68|P-value:5.68E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-2.71|P-value:5.96E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.12|P-value:9.32E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.46|P-value:1.68E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.57|P-value:9.23E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.14|P-value:8.44E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:-2.80|P-value:4.04E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.59|P-value:8.44E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.20|P-value:1.85E-7 ID:SGTC_2780|Compound:5215298|FD-Score:6.14|P-value:5.87E-14 ID:SGTC_2784|Compound:7567673|FD-Score:-3.58|P-value:9.17E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-2.68|P-value:6.79E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.92|P-value:1.30E-6 ID:SGTC_2813|Compound:7971799|FD-Score:3.79|P-value:2.21E-6 ID:SGTC_3150|Compound:9097574|FD-Score:2.62|P-value:7.36E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.92|P-value:2.40E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.73|P-value:3.22E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.88|P-value:1.31E-6 ID:SGTC_3215|Compound:9129942|FD-Score:3.30|P-value:3.23E-5 ID:SGTC_3226|Compound:9131256|FD-Score:3.27|P-value:3.67E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:2.57|P-value:8.92E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:2.77|P-value:3.92E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.59|P-value:8.45E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.14|P-value:8.56E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:5.01|P-value:6.82E-10 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.16|P-value:6.52E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:2.97|P-value:1.55E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.60|P-value:9.39E-4 ID:SGTC_668|Compound:1682-0499|FD-Score:-5.28|P-value:1.21E-10 ID:SGTC_669|Compound:0108-0021|FD-Score:3.66|P-value:4.55E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:4.11|P-value:3.34E-7 ID:SGTC_762|Compound:1165-0429|FD-Score:3.42|P-value:1.75E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:2.82|P-value:3.06E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:2.77|P-value:3.86E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.87|P-value:6.46E-13 ID:SGTC_1017|Compound:4239-0030|FD-Score:-2.67|P-value:7.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.77|P-value:3.20E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:2.80|P-value:3.45E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.66|P-value:6.32E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.23|P-value:5.63E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.61|P-value:7.54E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.34|P-value:2.62E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.08|P-value:9.49E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.29|P-value:4.09E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.83|P-value:2.97E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.38|P-value:2.08E-5 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.21|P-value:6.20E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:2.92|P-value:1.98E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.72|P-value:5.75E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:2.57|P-value:9.05E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-2.61|P-value:9.10E-4 ID:SGTC_1691|Compound:st019933|FD-Score:2.64|P-value:6.71E-4 ID:SGTC_1946|Compound:st076057|FD-Score:2.71|P-value:5.02E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.24|P-value:5.29E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.69|P-value:4.04E-6 ID:SGTC_2201|Compound:6605497|FD-Score:2.92|P-value:1.99E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.01|P-value:1.31E-4 ID:SGTC_2258|Compound:7960471|FD-Score:2.79|P-value:3.53E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.29|P-value:3.41E-5 ID:SGTC_2330|Compound:7979373|FD-Score:-3.26|P-value:4.83E-5 ID:SGTC_2368|Compound:9071271|FD-Score:2.68|P-value:5.68E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-2.71|P-value:5.96E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-3.12|P-value:9.32E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.46|P-value:1.68E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:2.57|P-value:9.23E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.14|P-value:8.44E-5 ID:SGTC_2657|Compound:nystatin|FD-Score:-2.80|P-value:4.04E-4 ID:SGTC_2692|Compound:st077426|FD-Score:2.59|P-value:8.44E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.20|P-value:1.85E-7 ID:SGTC_2780|Compound:5215298|FD-Score:6.14|P-value:5.87E-14 ID:SGTC_2784|Compound:7567673|FD-Score:-3.58|P-value:9.17E-6 ID:SGTC_2805|Compound:7950783|FD-Score:-2.68|P-value:6.79E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.92|P-value:1.30E-6 ID:SGTC_2813|Compound:7971799|FD-Score:3.79|P-value:2.21E-6 ID:SGTC_3150|Compound:9097574|FD-Score:2.62|P-value:7.36E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.92|P-value:2.40E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.73|P-value:3.22E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.88|P-value:1.31E-6 ID:SGTC_3215|Compound:9129942|FD-Score:3.30|P-value:3.23E-5 ID:SGTC_3226|Compound:9131256|FD-Score:3.27|P-value:3.67E-5

Top fitness defect scores for YDR339C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2780 5215298 6.14 71.4 µM 5.87E-14 3 4.08E-10 0.22
2 SGTC_996 3970-0799 5.87 1.8 µM 6.46E-13 8 2.15E-9 0.11
3 SGTC_411 enrofloxacin 5.01 100.0 µM 6.82E-10 DNA damage response 1 2.69E-7 1.68
4 SGTC_2693 st077581 4.20 40.7 µM 1.85E-7 5 1.32E-5 0.27
5 SGTC_761 k216-0224 4.11 480.0 µM 3.34E-7 4 2.00E-5 0.33
6 SGTC_3209 9113616 3.88 49.5 µM 1.31E-6 5 5.18E-5 0.11
7 SGTC_2813 7971799 3.79 71.4 µM 2.21E-6 9 7.48E-5 0.07
8 SGTC_3208 9114115 3.73 49.5 µM 3.22E-6 17 9.72E-5 0.06
9 SGTC_2002 4023503 3.69 131.0 µM 4.04E-6 mitochondrial processes 11 1.14E-4 0.04
10 SGTC_669 0108-0021 3.66 26.2 µM 4.55E-6 fatty acid desaturase (OLE1) 16 1.24E-4 0.03
11 SGTC_762 1165-0429 3.42 115.0 µM 1.75E-5 TSC3-RPN4 6 3.18E-4 0.06
12 SGTC_1350 1495-0454 3.38 146.0 µM 2.08E-5 5 3.58E-4 0.08
13 SGTC_1300 1094-0077 3.34 113.0 µM 2.62E-5 7 4.21E-4 0.08
14 SGTC_3215 9129942 3.30 49.5 µM 3.23E-5 11 4.87E-4 0.02
15 SGTC_2316 5844804 3.29 197.4 µM 3.41E-5 18 5.06E-4 0.02
16 SGTC_3226 9131256 3.27 49.5 µM 3.67E-5 1 5.33E-4 0.28
17 SGTC_450 aminopyrene 3.16 156.0 nM 6.52E-5 11 7.98E-4 0.04
18 SGTC_1315 1237-0019 3.08 3.7 µM 9.49E-5 14 0.00104 6.66E-4
19 SGTC_2253 7938677 3.01 135.8 µM 1.31E-4 9 0.00130 0.09
20 SGTC_639 0833-0042 2.97 114.0 µM 1.55E-4 13 0.00147 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 1.60E-69 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.265 6.39E-55 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.265 7.40E-55 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.241 2.21E-45 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.238 1.49E-44 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.228 1.22E-40 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.220 4.83E-38 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.214 5.40E-36 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.211 3.43E-35 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.200 1.25E-31 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.197 1.28E-30 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.184 7.82E-27 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.177 4.78E-25 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.175 1.67E-24 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.174 2.98E-24 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene