YDR341C

Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR341C / YDR341C

Click on Significant Values for Screen Details ID:SGTC_319|Compound:1348-1596|FD-Score:-3.84|P-value:1.53E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.74|P-value:3.68E-8 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.76|P-value:5.05E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:3.49|P-value:6.16E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.62|P-value:3.97E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.76|P-value:2.45E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.67|P-value:3.33E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-4.19|P-value:4.16E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.55|P-value:5.08E-4 ID:SGTC_2314|Compound:7727897|FD-Score:5.46|P-value:2.03E-7 ID:SGTC_2591|Compound:skatole|FD-Score:4.10|P-value:7.33E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.50|P-value:5.01E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.62|P-value:4.01E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.84|P-value:1.53E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-5.74|P-value:3.68E-8 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:4.76|P-value:5.05E-6 ID:SGTC_429|Compound:1112-0049|FD-Score:3.49|P-value:6.16E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.62|P-value:3.97E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.76|P-value:2.45E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.67|P-value:3.33E-4 ID:SGTC_1636|Compound:st007707|FD-Score:-4.19|P-value:4.16E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.55|P-value:5.08E-4 ID:SGTC_2314|Compound:7727897|FD-Score:5.46|P-value:2.03E-7 ID:SGTC_2591|Compound:skatole|FD-Score:4.10|P-value:7.33E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.50|P-value:5.01E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.62|P-value:4.01E-4

Top fitness defect scores for YDR341C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2314 7727897 5.46 200.0 µM 2.03E-7 1 2.43E-8 0.93
2 SGTC_423 5-fluorouracil 4.76 457.0 µM 5.05E-6 exosome 18 9.76E-7 0.09
3 SGTC_2591 skatole 4.10 100.0 µM 7.33E-5 4 2.10E-5 0.32
4 SGTC_927 2425-1185 3.76 123.0 µM 2.45E-4 4 8.39E-5 0.10
5 SGTC_1316 1272-0050 3.67 65.9 µM 3.33E-4 2 1.20E-4 0.33
6 SGTC_623 k072-0108 3.62 16.9 µM 3.97E-4 heme biosynthesis & mitochondrial translocase 16 1.46E-4 0.12
7 SGTC_3020 9089140 3.62 49.5 µM 4.01E-4 12 1.48E-4 0.27
8 SGTC_1881 5652484 3.55 16.0 µM 5.08E-4 TRP & mitochondrial translation 11 1.94E-4 0.06
9 SGTC_429 1112-0049 3.49 25.5 µM 6.16E-4 DNA damage response 13 2.42E-4 0.04
10 SGTC_180 1486-1293 3.33 102.8 µM 0.00101 11 4.27E-4 0.14
11 SGTC_741 4582-0002 3.30 126.0 µM 0.00112 6 4.81E-4 0.07
12 SGTC_1046 2001-0062 3.22 216.0 µM 0.00142 6 6.32E-4 0.04
13 SGTC_3141 9094609 3.17 49.5 µM 0.00167 iron homeostasis 27 7.59E-4 0.01
14 SGTC_3316 9136639 3.16 10.6 µM 0.00171 12 7.81E-4 0.15
15 SGTC_2062 5245942 3.13 200.0 µM 0.00187 7 8.63E-4 0.11
16 SGTC_1539 benzyladenosine 3.13 56.0 µM 0.00189 13 8.75E-4 0.01
17 SGTC_2586 curcumin 3.12 80.0 µM 0.00196 iron homeostasis 19 9.12E-4 0.04
18 SGTC_2306 7482397 3.08 179.5 µM 0.00217 RPP1 & pyrimidine depletion 16 0.00102 0.03
19 SGTC_1607 st000305 3.08 50.6 µM 0.00221 10 0.00105 0.17
20 SGTC_2105 5350118 3.06 200.0 µM 0.00235 16 0.00112 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.58E-14 YKL217W JEN1 hom Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
0.127 1.70E-13 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.120 3.39E-12 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.117 9.86E-12 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.104 1.69E-9 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.103 2.03E-9 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.088 3.57E-7 YDR147W EKI1 hom Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication
0.086 5.34E-7 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.084 1.02E-6 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.084 1.23E-6 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.083 1.41E-6 YFL004W VTC2 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.079 4.64E-6 YPR053C_d YPR053C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
0.079 5.00E-6 YLR219W MSC3 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress
0.079 5.09E-6 YJL194W CDC6 het Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.078 5.48E-6 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus