YDR344C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR344C / YDR344C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.22|P-value:7.49E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.57|P-value:2.16E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.46|P-value:4.28E-6 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.33|P-value:5.17E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-4.50|P-value:4.50E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.66|P-value:1.30E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.17|P-value:7.76E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.83|P-value:8.00E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:4.35|P-value:7.13E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.69|P-value:1.16E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.20|P-value:6.86E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.56|P-value:3.32E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.41|P-value:3.25E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.82|P-value:6.72E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.26|P-value:5.62E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.89|P-value:5.45E-7 ID:SGTC_2265|Compound:7929201|FD-Score:-3.77|P-value:1.00E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.74|P-value:1.11E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.22|P-value:9.53E-8 ID:SGTC_2398|Compound:5228213|FD-Score:3.92|P-value:4.45E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.93|P-value:5.33E-5 ID:SGTC_2482|Compound:5981709|FD-Score:5.00|P-value:3.13E-7 ID:SGTC_2485|Compound:5633444|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.57|P-value:1.81E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.95|P-value:4.78E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.32|P-value:4.44E-4 ID:SGTC_3328|Compound:9140624|FD-Score:7.41|P-value:7.84E-14 ID:SGTC_3335|Compound:9143315|FD-Score:-5.21|P-value:1.33E-7 ID:SGTC_3336|Compound:9143619|FD-Score:4.41|P-value:5.34E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.60|P-value:1.59E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.95|P-value:3.96E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.22|P-value:7.49E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.57|P-value:2.16E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.46|P-value:4.28E-6 ID:SGTC_92|Compound:0063-0024|FD-Score:-3.33|P-value:5.17E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-4.50|P-value:4.50E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.66|P-value:1.30E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.17|P-value:7.76E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:-3.83|P-value:8.00E-5 ID:SGTC_522|Compound:1273-0010|FD-Score:4.35|P-value:7.13E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.69|P-value:1.16E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.66|P-value:1.26E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.20|P-value:6.86E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-4.56|P-value:3.32E-6 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.41|P-value:3.25E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.82|P-value:6.72E-5 ID:SGTC_2021|Compound:4019055|FD-Score:3.26|P-value:5.62E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:4.89|P-value:5.45E-7 ID:SGTC_2265|Compound:7929201|FD-Score:-3.77|P-value:1.00E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.74|P-value:1.11E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.22|P-value:9.53E-8 ID:SGTC_2398|Compound:5228213|FD-Score:3.92|P-value:4.45E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.93|P-value:5.33E-5 ID:SGTC_2482|Compound:5981709|FD-Score:5.00|P-value:3.13E-7 ID:SGTC_2485|Compound:5633444|FD-Score:3.73|P-value:9.65E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.57|P-value:1.81E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.27|P-value:5.42E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.95|P-value:4.78E-5 ID:SGTC_2866|Compound:9034245|FD-Score:3.32|P-value:4.44E-4 ID:SGTC_3328|Compound:9140624|FD-Score:7.41|P-value:7.84E-14 ID:SGTC_3335|Compound:9143315|FD-Score:-5.21|P-value:1.33E-7 ID:SGTC_3336|Compound:9143619|FD-Score:4.41|P-value:5.34E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.60|P-value:1.59E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.95|P-value:3.96E-5

Top fitness defect scores for YDR344C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3328 9140624 7.41 29.0 µM 7.84E-14 1 6.21E-14
2 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 5.22 200.0 µM 9.53E-8 3 8.79E-8
3 SGTC_2482 5981709 5.00 142.7 µM 3.13E-7 PDR1 21 2.92E-7
4 SGTC_2115 tiliquinol 4.89 12.8 µM 5.45E-7 2 5.12E-7
5 SGTC_90 0870-0863 4.46 4.6 µM 4.28E-6 34 4.09E-6
6 SGTC_3336 9143619 4.41 71.4 µM 5.34E-6 10 5.12E-6
7 SGTC_522 1273-0010 4.35 11.6 µM 7.13E-6 60S ribosome export 18 6.86E-6
8 SGTC_3345 9148410 3.95 3.6 µM 3.96E-5 8 3.87E-5
9 SGTC_2398 5228213 3.92 48.8 µM 4.45E-5 iron homeostasis 40 4.35E-5
10 SGTC_1407 3909-7909 3.82 12.3 µM 6.72E-5 60S ribosome export 15 6.59E-5
11 SGTC_2485 5633444 3.73 17.8 µM 9.65E-5 redox potentiating 53 9.49E-5
12 SGTC_649 1123-0311 3.69 367.0 µM 1.16E-4 endomembrane recycling 82 1.14E-4
13 SGTC_653 0203-0016 3.66 55.2 µM 1.26E-4 23 1.24E-4
14 SGTC_1029 k015-0030 3.66 64.7 µM 1.26E-4 40 1.24E-4
15 SGTC_155 k072-0202 3.66 43.6 µM 1.30E-4 21 1.28E-4
16 SGTC_3342 9147791 3.60 14.5 µM 1.59E-4 26 1.57E-4
17 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.57 92.6 µM 1.81E-4 35 1.79E-4
18 SGTC_1381 2324-0066 3.41 62.1 µM 3.25E-4 47 3.23E-4
19 SGTC_2866 9034245 3.32 58.4 µM 4.44E-4 20 4.42E-4
20 SGTC_2315 7733312 3.27 200.0 µM 5.42E-4 48 5.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.49E-11 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.113 5.35E-11 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.102 2.73E-9 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.099 9.71E-9 YDL234C GYP7 hom GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
0.097 1.86E-8 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.097 2.01E-8 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.096 2.79E-8 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.089 2.53E-7 YJR112W NNF1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
0.087 5.03E-7 YIL050W PCL7 hom Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
0.086 6.76E-7 YOR266W PNT1 hom Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
0.086 6.78E-7 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
0.082 1.75E-6 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.080 3.13E-6 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.079 4.27E-6 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.079 4.61E-6 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology