YDR346C / SVF1

Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR346C / SVF1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.55|P-value:1.24E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.62|P-value:1.34E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:3.84|P-value:2.27E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.23|P-value:8.61E-7 ID:SGTC_155|Compound:k072-0202|FD-Score:3.95|P-value:1.59E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.44|P-value:2.48E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:4.52|P-value:1.84E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.65|P-value:1.24E-12 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.35|P-value:2.79E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:7.45|P-value:4.42E-12 ID:SGTC_805|Compound:3852-0218|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.13|P-value:8.28E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:3.64|P-value:4.59E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:7.59|P-value:1.78E-12 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.57|P-value:5.60E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.80|P-value:2.10E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.66|P-value:4.24E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.35|P-value:9.35E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.41|P-value:7.70E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.30|P-value:1.34E-21 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.49|P-value:7.36E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.61|P-value:4.98E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.37|P-value:8.88E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.47|P-value:6.32E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-4.12|P-value:6.70E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.69|P-value:3.87E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.68|P-value:3.91E-4 ID:SGTC_1800|Compound:st050079|FD-Score:7.54|P-value:2.44E-12 ID:SGTC_1801|Compound:st050089|FD-Score:5.00|P-value:2.40E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.67|P-value:4.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.65|P-value:3.57E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:-3.37|P-value:8.73E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.01|P-value:1.26E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.18|P-value:6.71E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.82|P-value:2.46E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.52|P-value:5.37E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.55|P-value:1.24E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:5.62|P-value:1.34E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:3.84|P-value:2.27E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:5.23|P-value:8.61E-7 ID:SGTC_155|Compound:k072-0202|FD-Score:3.95|P-value:1.59E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.44|P-value:2.48E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:4.52|P-value:1.84E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.65|P-value:1.24E-12 ID:SGTC_718|Compound:1130-0073|FD-Score:-4.35|P-value:2.79E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:7.45|P-value:4.42E-12 ID:SGTC_805|Compound:3852-0218|FD-Score:3.97|P-value:1.46E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.13|P-value:8.28E-5 ID:SGTC_921|Compound:1561-0023|FD-Score:3.64|P-value:4.59E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:7.59|P-value:1.78E-12 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.57|P-value:5.60E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.80|P-value:2.10E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.66|P-value:4.24E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.35|P-value:9.35E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.41|P-value:7.70E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:10.30|P-value:1.34E-21 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.49|P-value:7.36E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.61|P-value:4.98E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.37|P-value:8.88E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.47|P-value:6.32E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-4.12|P-value:6.70E-5 ID:SGTC_1548|Compound:st061468|FD-Score:3.69|P-value:3.87E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.68|P-value:3.91E-4 ID:SGTC_1800|Compound:st050079|FD-Score:7.54|P-value:2.44E-12 ID:SGTC_1801|Compound:st050089|FD-Score:5.00|P-value:2.40E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.67|P-value:4.07E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.65|P-value:3.57E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:-3.37|P-value:8.73E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.01|P-value:1.26E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.18|P-value:6.71E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.82|P-value:2.46E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.52|P-value:5.37E-4

Top fitness defect scores for YDR346C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1161 k007-0610 10.30 110.0 µM 1.34E-21 ERAD & cell cycle 13 2.54E-25
2 SGTC_528 3492-0019 7.65 172.0 µM 1.24E-12 calcium & mitochondrial duress 83 1.04E-14
3 SGTC_926 2268-1401 7.59 59.4 µM 1.78E-12 TSC3-RPN4 6 1.59E-14
4 SGTC_1800 st050079 7.54 29.1 µM 2.44E-12 NEO1-PIK1 16 2.31E-14
5 SGTC_733 4069-0007 7.45 56.1 µM 4.42E-12 ERAD & cell cycle 25 4.67E-14
6 SGTC_108 0509-0257 5.62 621.1 µM 1.34E-7 15 9.29E-9
7 SGTC_143 4032-1194 5.23 15.7 µM 8.61E-7 27 8.39E-8
8 SGTC_1801 st050089 5.00 28.4 µM 2.40E-6 NEO1-PIK1 75 2.81E-7
9 SGTC_362 0310-0100 4.52 9.0 µM 1.84E-5 RPP1 & pyrimidine depletion 19 3.12E-6
10 SGTC_304 1310-0298 4.44 97.0 µM 2.48E-5 cell wall 45 4.44E-6
11 SGTC_3141 9094609 4.18 49.5 µM 6.71E-5 iron homeostasis 33 1.44E-5
12 SGTC_860 0443-0016 4.13 25.1 µM 8.28E-5 29 1.84E-5
13 SGTC_2934 9036370 4.01 36.9 µM 1.26E-4 31 3.04E-5
14 SGTC_805 3852-0218 3.97 479.0 µM 1.46E-4 ERAD & cell cycle 70 3.61E-5
15 SGTC_155 k072-0202 3.95 43.6 µM 1.59E-4 17 3.99E-5
16 SGTC_114 0364-0001 3.84 490.3 µM 2.27E-4 54 6.08E-5
17 SGTC_3143 9086658 3.82 49.5 µM 2.46E-4 50 6.65E-5
18 SGTC_1548 st061468 3.69 90.8 µM 3.87E-4 11 1.14E-4
19 SGTC_1731 st035964 3.68 63.0 µM 3.91E-4 38 1.15E-4
20 SGTC_1803 st050068 3.67 52.4 µM 4.07E-4 NEO1-PIK1 202 1.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.247 5.47E-48 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.238 1.72E-44 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.228 8.93E-41 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.211 4.77E-35 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.207 1.15E-33 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.203 1.40E-32 YDL023C_d YDL023C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
0.193 1.86E-29 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.184 6.83E-27 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.177 5.31E-25 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.176 7.69E-25 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.171 1.80E-23 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.171 2.40E-23 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.171 2.55E-23 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.162 3.39E-21 YNL180C RHO5 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
0.162 4.59E-21 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA