YDR347W / MRP1

Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR347W / MRP1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.44|P-value:1.13E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.86|P-value:1.16E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:5.01|P-value:8.85E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:3.33|P-value:7.37E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.45|P-value:1.04E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.53|P-value:2.24E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:13.80|P-value:9.05E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.82|P-value:1.41E-8 ID:SGTC_283|Compound:0987-0079|FD-Score:3.63|P-value:2.66E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:13.60|P-value:1.29E-38 ID:SGTC_314|Compound:1671-0008|FD-Score:3.71|P-value:1.99E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.53|P-value:6.63E-8 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.75|P-value:1.99E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.67|P-value:4.07E-6 ID:SGTC_456|Compound:gingerol|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.75|P-value:1.73E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.73|P-value:3.23E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:3.54|P-value:3.71E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.34|P-value:7.22E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.57|P-value:3.23E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.53|P-value:3.80E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.66|P-value:2.40E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.48|P-value:4.43E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.46|P-value:1.04E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.31|P-value:8.02E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.24|P-value:9.89E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.30|P-value:2.08E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:7.75|P-value:6.73E-14 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.85|P-value:1.19E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.56|P-value:3.30E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.74|P-value:1.74E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-8.00|P-value:1.04E-14 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.34|P-value:1.72E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.26|P-value:9.44E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.00|P-value:9.11E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.37|P-value:6.62E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.37|P-value:1.48E-7 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.91|P-value:9.74E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.27|P-value:8.91E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.34|P-value:7.29E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.24|P-value:9.99E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.05|P-value:5.66E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.30|P-value:8.14E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.57|P-value:3.25E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.55|P-value:3.41E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.52|P-value:8.12E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.97|P-value:7.60E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.64|P-value:2.57E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.69|P-value:2.17E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.47|P-value:4.63E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.72|P-value:1.92E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.17|P-value:3.48E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:2.53E-5 ID:SGTC_2705|Compound:st078069|FD-Score:-3.80|P-value:1.39E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.61|P-value:1.35E-10 ID:SGTC_3020|Compound:9089140|FD-Score:3.45|P-value:5.04E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.36|P-value:6.69E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.44|P-value:1.13E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.86|P-value:1.16E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:5.01|P-value:8.85E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:3.33|P-value:7.37E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.45|P-value:1.04E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:6.53|P-value:2.24E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:13.80|P-value:9.05E-40 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.82|P-value:1.41E-8 ID:SGTC_283|Compound:0987-0079|FD-Score:3.63|P-value:2.66E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:13.60|P-value:1.29E-38 ID:SGTC_314|Compound:1671-0008|FD-Score:3.71|P-value:1.99E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:5.53|P-value:6.63E-8 ID:SGTC_403|Compound:arphamenine a|FD-Score:5.75|P-value:1.99E-8 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.67|P-value:4.07E-6 ID:SGTC_456|Compound:gingerol|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.75|P-value:1.73E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.88|P-value:1.06E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.73|P-value:3.23E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:3.54|P-value:3.71E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.34|P-value:7.22E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.57|P-value:3.23E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.53|P-value:3.80E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.66|P-value:2.40E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.48|P-value:4.43E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:4.46|P-value:1.04E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.31|P-value:8.02E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.24|P-value:9.89E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.30|P-value:2.08E-7 ID:SGTC_908|Compound:3448-7491|FD-Score:7.75|P-value:6.73E-14 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:-3.85|P-value:1.19E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.56|P-value:3.30E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-3.74|P-value:1.74E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-8.00|P-value:1.04E-14 ID:SGTC_1038|Compound:k292-0204|FD-Score:4.34|P-value:1.72E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.26|P-value:9.44E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.00|P-value:9.11E-7 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.37|P-value:6.62E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.37|P-value:1.48E-7 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.91|P-value:9.74E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.27|P-value:8.91E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.34|P-value:7.29E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.24|P-value:9.99E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.05|P-value:5.66E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.30|P-value:8.14E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.57|P-value:3.25E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.55|P-value:3.41E-4 ID:SGTC_2177|Compound:5811945|FD-Score:4.52|P-value:8.12E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.97|P-value:7.60E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.64|P-value:2.57E-4 ID:SGTC_2283|Compound:7944793|FD-Score:3.69|P-value:2.17E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.47|P-value:4.63E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.72|P-value:1.92E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.76|P-value:1.68E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.17|P-value:3.48E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.25|P-value:2.53E-5 ID:SGTC_2705|Compound:st078069|FD-Score:-3.80|P-value:1.39E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.61|P-value:1.35E-10 ID:SGTC_3020|Compound:9089140|FD-Score:3.45|P-value:5.04E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.36|P-value:6.69E-4

Top fitness defect scores for YDR347W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.80 5.3 µM 9.05E-40 122 1.94E-43
2 SGTC_310 1273-0058 13.60 1.1 µM 1.29E-38 mitochondrial stress 13 3.58E-42
3 SGTC_908 3448-7491 7.75 47.7 µM 6.73E-14 mitochondrial stress 20 4.43E-15
4 SGTC_173 1273-0061 6.53 2.7 µM 2.24E-10 mitochondrial stress 97 3.19E-11
5 SGTC_275 trichlorophene 5.82 5.7 µM 1.41E-8 mitochondrial stress 124 2.99E-9
6 SGTC_403 arphamenine a 5.75 50.0 µM 1.99E-8 60S ribosome export 3 4.35E-9
7 SGTC_365 0121-0052 5.53 13.6 µM 6.63E-8 mitochondrial response to ROS 19 1.62E-8
8 SGTC_1426 4048-4480 5.37 71.7 µM 1.48E-7 60S ribosome export 3 3.90E-8
9 SGTC_832 4083-0019 5.30 164.0 µM 2.08E-7 translation 31 5.65E-8
10 SGTC_101 0490-5701 5.01 117.5 µM 8.85E-7 2 2.76E-7
11 SGTC_1352 1496-0991 5.00 99.0 µM 9.11E-7 tubulin folding & SWR complex 12 2.85E-7
12 SGTC_539 4859-0462 4.73 2.5 µM 3.23E-6 RNA pol III & RNase P/MRP 9 1.14E-6
13 SGTC_2177 5811945 4.52 192.0 µM 8.12E-6 17 3.12E-6
14 SGTC_815 1582-0027 4.46 36.9 µM 1.04E-5 15 4.08E-6
15 SGTC_10 0279-0212 4.44 42.6 µM 1.13E-5 TRP & mitochondrial translation 98 4.47E-6
16 SGTC_1038 k292-0204 4.34 154.0 µM 1.72E-5 9 7.06E-6
17 SGTC_2688 kanamycin b 4.25 96.7 µM 2.53E-5 calcium & mitochondrial duress 329 1.08E-5
18 SGTC_2526 patulin 4.17 37.6 µM 3.48E-5 79 1.53E-5
19 SGTC_1883 5-benzylidenerhodanine 4.05 20.0 µM 5.66E-5 TRP & mitochondrial translation 67 2.60E-5
20 SGTC_2232 chlorophetanol 3.97 41.5 µM 7.60E-5 TRP & mitochondrial translation 122 3.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.481 1.84E-193 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.478 8.20E-191 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.457 3.04E-173 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.454 4.54E-170 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.448 3.08E-165 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.431 4.87E-152 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.423 6.02E-146 YKL016C ATP7 hom Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.420 1.97E-143 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.417 1.37E-141 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.417 1.47E-141 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.417 1.96E-141 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.416 1.04E-140 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.415 4.10E-140 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.411 1.02E-136 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.408 4.40E-135 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss